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Hangzhou Think Chemical Co. Ltd

Lurasidone Intermediate (3aR,4S,7R,7aS)-rel-Hexahydro-4,7-methano-1H-isoindole-1,3(2H)-dione[CAS:14805-29-9] (1R,2R)-1,2-Cyclohexanedimethanol[CAS:65376-05-8] Lurasidone Hydrochloride [CAS:367514-88-3] HANGZHOU THINK CHEMICAL CO., LTD. (THINKC

High purity (3aR,4S,7R,7aS) 4,7-Methano-1H-isoindole-1,3(2H)-dione for Lurasidone

Cas:14805-29-9

Min.Order:1 Kilogram

Negotiable

Type:Other

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Jinan Finer Chemical Co., Ltd

Product Description Product website: http://www.finerchem.com/pro01en/id/254.html Product Name (3aR,4S,7R,7aS)-rel-Hexahydro-4,7-methano-1H-isoindole-1,3(2H)-dione

(3aR,4S,7R,7aS)-rel-Hexahydro-4,7-methano-1H-isoindole-1,3(2H)-dione

Cas:14805-29-9

Min.Order:1 Gram

FOB Price: $24.0

Type:Lab/Research institutions

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Dayang Chem (Hangzhou) Co.,Ltd.

As a leading manufacturer and supplier of chemicals in China, DayangChem not only supply popular chemicals, but also DayangChem's R&D center offer custom synthesis services. DayangChem can provide different quantities of custom synthesis ch

(3aR,4S,7R,7aS) 4,7-Methano-1H-isoindole-1,3(2H)-dione Manufacturer/High quality/Best price/In stock

Cas:14805-29-9

Min.Order:1 Kilogram

FOB Price: $3.0

Type:Lab/Research institutions

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Hebei yanxi chemical co.,LTD.

hebei yanxi chemical co., LTD who registered capital of 10 million yuan, nearly to $2 million, we have a pharmaceutical raw materials factory production of pharmaceutical raw materials, and a reagent r&d center, and we do research and developm

(3aR,4S,7R,7aS) 4,7-Methano-1H-isoindole-1,3(2H)-dione China supplier CAS NO.14805-29-9

Cas:14805-29-9

Min.Order:1 Metric Ton

FOB Price: $1.0 / 3.0

Type:Manufacturers

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Ality Chemical Corporation

The above product is Ality Chemical's strong item with best price, good quality and fast supply. Ality Chemical has been focusing on the research and production of this field for over 14 years. At the same time, we are always committed to providi

Enke Pharma-tech Co.,Ltd. (Cangzhou, China )

Cangzhou Enke Pharma Tech Co.,ltd. is located in Cangzhou City, Hebei province ,where is a famous petroleum chemical industry city in China. Enke Pharma a high-tech enterprise ,and we are dedicated to developing and manufacturing new api, intermedi

(3aR,4S,7R,7aS)-rel-Hexahydro-4,7-methano-1H-isoindole-1,3(2H)-dione

Cas:14805-29-9

Min.Order:1 Kilogram

FOB Price: $1.0

Type:Manufacturers

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Shanghai SE Pharm Co., Ltd

1. made in GMP plant, commerially 2. Normal Stock: 500kgs 3. Audit accepted. Related documents are available to offer and audited by many clients, such as Lupin, MSN, Dr reddy etc 4. Chromatographic Purity (HPLC): not less than 99

(3aR,4S,7R,7aS)-rel-Hexahydro-4,7-methano-1H-isoindole-1,3(2H)-dione

Cas:14805-29-9

Min.Order:0 Metric Ton

Negotiable

Type:Manufacturers

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Chemwill Asia Co., Ltd.

Our main production base is located in Xuzhou industry park. We are certified both to the ISO 9001 and ISO 14001 Standards, have a safety management system in place.Our R&D team masters core technology for process-design of target building block

exo-2,3-Norbornanedicarboximide

Cas:14805-29-9

Min.Order:5 Kiloliter

FOB Price: $1.2 / 5.0

Type:Manufacturers

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Henan Tianfu Chemical Co., Ltd.

Our company was built in 2009 with an ISO certificate.In the past 5 years, we have grown up as a famous fine chemicals supplier in China and we had established stable business relationships with Samsung,LG,Merck,Thermo Fisher Scientific and so on.O

high quality (3aR,4S,7R,7aS) 4,7-Methano-1H-isoindole-1,3(2H)-dione

Cas:14805-29-9

Min.Order:1 Gram

FOB Price: $1.0

Type:Lab/Research institutions

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LIDE PHARMACEUTICALS LIMITED

LIDE PHARMACEUTICALS LIMITED is a professional chemicals and APIs leading manufacturer in China. Our core business line covers APIs, Intermediates, Herb extract, etc.

(3aR,4S,7R,7aS) 4,7-Methano-1H-isoindole-1,3(2H)-dione

Cas:14805-29-9

Min.Order:1 Kilogram

FOB Price: $0.9 / 1.0

Type:Lab/Research institutions

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Sinoway Industrial Co., Ltd.

Why is SINOWAY: 1) Specialized in pharmaceutical and healthcare industrial for 34 years. 2) ISO 9001:2015 & SGS audited supplier . 3) Accept various payment terms : T.T 30-60 days. 4) We have warehouse in USA with quickly shipment . 5) We c

Lurasidone intermediate/(3aR,4S,7R,7aS) 4,7-Methano-1H-isoindole-1,3(2H)-dione CAS 14805-29-9

Cas:14805-29-9

Min.Order:25 Kilogram

FOB Price: $100.0

Type:Trading Company

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Zhuozhou Wenxi import and Export Co., Ltd

WITH US,YOUR MONEY IN SAFE,YOUR BUSINESS IN SAFE 1)Quick Response Within 12 hours; 2)Quality Guarantee: All products are strictly tested by our QC, confirmed by QA and approved by third party lab in China, USA, Canada, Germany, UK, Italy, France et

New production CAS 14805-29-9 with best quality

Cas:14805-29-9

Min.Order:1 Kilogram

FOB Price: $139.0 / 210.0

Type:Trading Company

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Henan Sinotech Import&Export Corporation

Product Name: (3aR,4S,7R,7aS) 4,7-Methano-1H-isoindole-1,3(2H)-dione Synonyms: (3aR,4S,7R,7aS) 4,7-Methano-1H-isoindole-1,3(2H)-dione;Nsc238001;2,3-Norbornanedicarboximide, exo- (8CI);(3aR,4S,7R,7aS)-rel-He

(3aR,4S,7R,7aS)-rel-Hexahydro-4,7-methano-1H-isoindole-1,3(2H)-dione CAS No.14805-29-9

Cas:14805-29-9

Min.Order:5 Metric Ton

FOB Price: $1.0 / 2.0

Type:Other

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Hebei Nengqian Chemical Import and Export Co., LTD

Our Advantage Rich Experience Our products are sold all over Europe,North&South America, Sino-East, Asia and pacific area as well as Africa,we establish long term. Quality service Company cooperates with research institutes. We strictly con

14805-29-9 (3aR,4S,7R,7aS) 4,7-Methano-1H-isoindole-1,3(2H)-dione

Cas:14805-29-9

Min.Order:1 Kilogram

FOB Price: $15.0 / 50.0

Type:Trading Company

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Hubei Langyou International Trading Co., Ltd

Advantages: Hubei XinRunde Chemical Co., Ltd is a renowned pharmaceutical manufacturer. We can offer high quality products at competitive price in quick delivery with 100% custom pass guaranteed. Never stop striving to offer our best s

99% (3aR,4S,7R,7aS) 4,7-Methano-1H-isoindole-1,3(2H)-dione CAS:14805-29-9

Cas:14805-29-9

Min.Order:10 Gram

Negotiable

Type:Other

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Shanghai Upbio Tech Co.,Ltd

1.In No Less 10 years exporting experience. you can 100% received goods 2.Lower Price with higher quality 3,Free sample 4,We are sincerely responsible for the "product quality" and "After Service" Upbio is Specializ

(3aR,4S,7R,7aS) 4,7-Methano-1H-isoindole-1,3(2H)-dione

Cas:14805-29-9

Min.Order:1 Gram

Negotiable

Type:Lab/Research institutions

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Baoji Guokang Healthchem co.,ltd

Our company has been in existence for 10 years since its establishment. We have our own unique team. The company integrates independent research and development, production and sales. We have established famous brands at home and abroad. At present

Hot selling high quality CAS 14805-29-9with best price

Cas:14805-29-9

Min.Order:1 Kilogram

FOB Price: $49.0 / 121.0

Type:Trading Company

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Qingdao Beluga Import and Export Co., LTD

Beluga chemical professional supply (3aR,4S,7R,7aS)-hexahydro-1H-4,7-methanoisoindole-1,3(2H)-dione CAS 14805-29-9 1. Beluga Chemical has a professional RESEARCH and development team and strong technical force to ensure technical support and resea

(3aR,4S,7R,7aS)-hexahydro-1H-4,7-methanoisoindole-1,3(2H)-dione CAS 14805-29-9

Cas:14805-29-9

Min.Order:1 Gram

Negotiable

Type:Lab/Research institutions

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Shandong Hanjiang Chemical Co., Ltd.

Hello, dear friend! I'm Hansen and Allen from China. Welcome to my lookchem mall! The following is a brief introduction of our company's products and services. If you are interested in our products, please contact us by emai

(3aR,4S,7R,7aS) 4,7-Methano-1H-isoindole-1,3(2H)-dione

Cas:14805-29-9

Min.Order:1 Kilogram

Negotiable

Type:Lab/Research institutions

inquiry

Henan Wentao Chemical Product Co., Ltd.

Henan Wentao Chemical Product Co.,Ltd is Located in Zhengzhou High-tech Development Zone with import and export license, We passed ISO 9001:2008 as well, Henan Wentao has developed more than 1000 compounds, which are widely used in the fields of prod

(3aR,4S,7R,7aS) 4,7-Methano-1H-isoindole-1,3(2H)-dione

Cas:14805-29-9

Min.Order:0

Negotiable

Type:Lab/Research institutions

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Triumph International Development Limilted

Appearance:white powder without visible impurities Storage:Store in a cool,dry place and keep away from direct strong light Package:As customer request Application:Used for research and industrial manufacture. Transportation:By

(3aR,4S, 7R, 7aS) 4,7-Methano-1H-isoindole-1,3(2H)-dione

Cas:14805-29-9

Min.Order:100 Gram

Negotiable

Type:Lab/Research institutions

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Afine Chemicals Limited

Company Introduction 1. Established in 2005, with two independent business divisions: Fine chemicals division; Pharmaceutical division. 2. Main product: Optical brightener Textile auxiliary Dye stuff Pigments

(3AR,4S,7R,7AS) 4,7-METHANO-1H-ISOINDOLE-1,3(2H)-DIONE

Cas:14805-29-9

Min.Order:1 Gram

Negotiable

Type:Lab/Research institutions

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SHANGHAI T&W PHARMACEUTICAL CO., LTD.

A substitute for perfluorooctanoic acid, mainly used as a surfactant, dispersant, additive, etc Appearance:White solid or Colorless liquid Purity:99.3 % We will ship the goods in a timely manner as required We can provide relevant documents acc

(3aR,4S,7R,7aS) 4,7-Methano-1H-isoindole-1,3(2H)-dione

Cas:14805-29-9

Min.Order:4 Kilogram

Negotiable

Type:Lab/Research institutions

inquiry

Hangzhou J&H Chemical Co., Ltd.

J&H CHEM R&D center can offer custom synthesis according to the contract research and development services for the fine chemicals, pharmaceutical, biotechnique and some of the other chemicals. J&H CHEM has some Manufacturing base in Jia

2,3-Norbornanedicarboximide, exo- (8CI);

Cas:14805-29-9

Min.Order:0

Negotiable

Type:Lab/Research institutions

inquiry

Shanghai Massive Chemical Technology Co., Ltd.

Massive Chemical is certified with ISO9001 and ISO14001 manufacturer for this product. We will offer all documents as requirement for the materials which includes, Certificate of Analysis, Material Safety Data Sheet, and Method of Analysis and

(3aR,4S,7R,7aS) 4,7-Methano-1H-isoindole-1,3(2H)-dione

Cas:14805-29-9

Min.Order:1 Gram

FOB Price: $1.0

Type:Lab/Research institutions

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Zibo Hangyu Biotechnology Development Co., Ltd

Zibo Hangyu Biotechnology Development Co., Ltd is a leading manufacturer and supplier of chemicals in China. We develop produce and distribute high quality pharmaceuticals, intermediates, special chemicals and OLED intermediates and other fine chemi

(3aR,4S,7R,7aS)4,7-methano-1H-isoindole-1,3(2H)-dione

Cas:14805-29-9

Min.Order:10 Gram

FOB Price: $100.0

Type:Lab/Research institutions

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Siwei Development Group Ltd.

Product name: (3aR,4S,7R,7aS)-4,7-Methano-1H-Isoindole-1,3(2H)-Dione CAS No.: 14805-29-9 Molecule Formula:C9H11NO2 Molecule Weight:165.19 Purity: 98.0% Package: 25kg/drum Description:White powder Manufacture Standards:Enterprise Stand

Lower Price (3aR,4S,7R,7aS)-4,7-Methano-1H-Isoindole-1,3(2H)-Dione

Cas:14805-29-9

Min.Order:1 Kilogram

Negotiable

Type:Trading Company

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Zibo Dorne chemical technology co. LTD

Product Details Grade: pharmaceutical grade Purity:99%+ ProductionCapacity: 1000 Kilogram/Month Scope of use: For scientific research only(The product must be used legally) Our Advantage 1. Best quality with competitive price. 2. Quick shipping,

(3aR,4S,7R,7aS) 4,7-Methano-1H-isoindole-1,3(2H)-dione

Cas:14805-29-9

Min.Order:1 Kilogram

Negotiable

Type:Lab/Research institutions

inquiry

Shanghai Minstar Chemical Co., Ltd

(3aR,4S,7R,7aS) 4,7-Methano-1H-isoindole-1,3(2H)-dione Basic information Product Name: (3aR,4S,7R,7aS) 4,7-Methano-1H-isoindole-1,3(2H)-dione Synonyms: 4,7-Methano-1H-isoindole-1,3(2H)-dione, hexahydro-, (3aR,4S,7R,7aS)-rel-;(3aR,4S,7R,7aS)-He

(3aR,4S,7R,7aS) 4,7-Methano-1H-isoindole-1,3(2H)-dione

Cas:14805-29-9

Min.Order:1 Gram

Negotiable

Type:Lab/Research institutions

inquiry

EAST CHEMSOURCES LIMITED

factory?direct?saleAppearance:White Powder Storage:Store In Dry, Cool And Ventilated Place Package:25kg/drum, also according to the clients requirement Application:It is widely used as a thickener, emulsifier and stabilizer Transportation:By Sea Or B

(3aR,4S,7R,7aS) 4,7-Methano-1H-isoindole-1,3(2H)-dione

Cas:14805-29-9

Min.Order:1 Kilogram

FOB Price: $18.0 / 20.0

Type:Trading Company

inquiry

Synthetic route

(1R,2S,6R,7S)-4-azatricyclo[5.2.1.0(2,6)]dec-8-ene-3,5-dione
6265-30-1

(1R,2S,6R,7S)-4-azatricyclo[5.2.1.0(2,6)]dec-8-ene-3,5-dione

(3aR,4S,7R,7aS)‑4,7‑methylene‑1H‑isoindole‑1,3(2H)-dione
14805-29-9

(3aR,4S,7R,7aS)‑4,7‑methylene‑1H‑isoindole‑1,3(2H)-dione

Conditions
ConditionsYield
With palladium 10% on activated carbon; hydrogen In methanol Autoclave; Industrial scale;91.4%
exo-bicyclo[2.2.1]heptane-2,3-dicarboxylic anhydride
14166-28-0

exo-bicyclo[2.2.1]heptane-2,3-dicarboxylic anhydride

(3aR,4S,7R,7aS)‑4,7‑methylene‑1H‑isoindole‑1,3(2H)-dione
14805-29-9

(3aR,4S,7R,7aS)‑4,7‑methylene‑1H‑isoindole‑1,3(2H)-dione

Conditions
ConditionsYield
With ammonium hydroxide In tetrahydrofuran at 190℃; for 2h;80.5%
Multi-step reaction with 2 steps
1: triethylamine / toluene / Reflux
2: pyridine / 0 - 20 °C
View Scheme
Stage #1: exo-bicyclo[2.2.1]heptane-2,3-dicarboxylic anhydride In tetrahydrofuran at 25 - 35℃; for 0.166667h;
Stage #2: With ammonia In tetrahydrofuran; water at 0 - 35℃;
(1R,2R,6S,7S)-4-oxa-tricyclo[5.2.1.02,6]dec-8-ene-3,5-dione
2746-19-2

(1R,2R,6S,7S)-4-oxa-tricyclo[5.2.1.02,6]dec-8-ene-3,5-dione

(3aR,4S,7R,7aS)‑4,7‑methylene‑1H‑isoindole‑1,3(2H)-dione
14805-29-9

(3aR,4S,7R,7aS)‑4,7‑methylene‑1H‑isoindole‑1,3(2H)-dione

Conditions
ConditionsYield
Multi-step reaction with 2 steps
1: 95.9 percent / H2 / 10percent Pd/C / H2O; tetrahydrofuran / 1.5 h / Ambient temperature
2: 80.5 percent / 7percent aq. NH3 / tetrahydrofuran / 2 h / 190 °C
View Scheme
Multi-step reaction with 2 steps
1: 95.9 percent / H2 / 10percent Pd-C/ 50percent H2O / tetrahydrofuran / 1.5 h / Ambient temperature
2: 80.5 percent / 7percent aq. NH3 / tetrahydrofuran / 2 h / 190 °C
View Scheme
Multi-step reaction with 2 steps
1.1: palladium on activated charcoal; hydrogen / 25 - 35 °C / 3750.38 Torr / Inert atmosphere; Autoclave
2.1: tetrahydrofuran / 0.17 h / 25 - 35 °C
2.2: 0 - 35 °C
View Scheme
(3aR,4S,7R,7aS)-2-(((1R,2R)-2-(hydroxymethyl)cyclohexyl)methy)hexahydro-1H-4,7-methanoisoindole-1,3(2H)-dione

(3aR,4S,7R,7aS)-2-(((1R,2R)-2-(hydroxymethyl)cyclohexyl)methy)hexahydro-1H-4,7-methanoisoindole-1,3(2H)-dione

methanesulfonyl chloride
124-63-0

methanesulfonyl chloride

(3aR,4S,7R,7aS)‑4,7‑methylene‑1H‑isoindole‑1,3(2H)-dione
14805-29-9

(3aR,4S,7R,7aS)‑4,7‑methylene‑1H‑isoindole‑1,3(2H)-dione

Conditions
ConditionsYield
Stage #1: (3aR,4S,7R,7aS)-2-(((1R,2R)-2-(hydroxymethyl)cyclohexyl)methy)hexahydro-1H-4,7-methanoisoindole-1,3(2H)-dione; methanesulfonyl chloride With pyridine at 0 - 20℃;
Stage #2: With hydrogenchloride In water
cyclopenta-1,3-diene
542-92-7

cyclopenta-1,3-diene

(3aR,4S,7R,7aS)‑4,7‑methylene‑1H‑isoindole‑1,3(2H)-dione
14805-29-9

(3aR,4S,7R,7aS)‑4,7‑methylene‑1H‑isoindole‑1,3(2H)-dione

Conditions
ConditionsYield
Multi-step reaction with 3 steps
1.1: 1 h / 200 °C
2.1: palladium on activated charcoal; hydrogen / 25 - 35 °C / 3750.38 Torr / Inert atmosphere; Autoclave
3.1: tetrahydrofuran / 0.17 h / 25 - 35 °C
3.2: 0 - 35 °C
View Scheme
3,6-endomethylene-1,2,3,6-tetrahydrophthalic anhydride
129-64-6

3,6-endomethylene-1,2,3,6-tetrahydrophthalic anhydride

(3aR,4S,7R,7aS)‑4,7‑methylene‑1H‑isoindole‑1,3(2H)-dione
14805-29-9

(3aR,4S,7R,7aS)‑4,7‑methylene‑1H‑isoindole‑1,3(2H)-dione

Conditions
ConditionsYield
Multi-step reaction with 2 steps
1: ammonium acetate / 135 °C / Industrial scale
2: hydrogen; palladium 10% on activated carbon / methanol / Autoclave; Industrial scale
View Scheme
1,5-dibromo-pentane
111-24-0

1,5-dibromo-pentane

(3aR,4S,7R,7aS)‑4,7‑methylene‑1H‑isoindole‑1,3(2H)-dione
14805-29-9

(3aR,4S,7R,7aS)‑4,7‑methylene‑1H‑isoindole‑1,3(2H)-dione

N-(4-Bromopentyl)bicyclo<2.2.1>heptane-2,3-di-exo-carboximide
138274-10-9

N-(4-Bromopentyl)bicyclo<2.2.1>heptane-2,3-di-exo-carboximide

Conditions
ConditionsYield
With potassium carbonate In acetone Heating;100%
(1R,2R)-(-)-trans-cyclohexane-1,2-diylbis(methylene)dimethanesulfonate
186204-35-3

(1R,2R)-(-)-trans-cyclohexane-1,2-diylbis(methylene)dimethanesulfonate

(3aR,4S,7R,7aS)‑4,7‑methylene‑1H‑isoindole‑1,3(2H)-dione
14805-29-9

(3aR,4S,7R,7aS)‑4,7‑methylene‑1H‑isoindole‑1,3(2H)-dione

((1R,2R)-2-(((3aR,4S,7R,7aS)-1,3-dioxohexahydro-1H-4,7-methanoisoindol-2(3H)-yl)methyl)cyclohexyl)methylmethanesulfonate

((1R,2R)-2-(((3aR,4S,7R,7aS)-1,3-dioxohexahydro-1H-4,7-methanoisoindol-2(3H)-yl)methyl)cyclohexyl)methylmethanesulfonate

Conditions
ConditionsYield
With potassium carbonate In isopropyl alcohol for 4h;99%
(3aR,7aR)-4’-(benzo[d]isothiazol-3-yl)octahydrospiro[isoindole-2,1’-piperazin]-2-ium methanesulfonate
186204-37-5

(3aR,7aR)-4’-(benzo[d]isothiazol-3-yl)octahydrospiro[isoindole-2,1’-piperazin]-2-ium methanesulfonate

(3aR,4S,7R,7aS)‑4,7‑methylene‑1H‑isoindole‑1,3(2H)-dione
14805-29-9

(3aR,4S,7R,7aS)‑4,7‑methylene‑1H‑isoindole‑1,3(2H)-dione

(3aR,4S,7R,7aS)-2-[((1R,2R)-2-{[4-(l1,2-benzisothiazol-3-yl)piperazin-1-yl]methyl}cyclohexyl)methyl]hexahydro-1H-4,7-methanisoindol-1,3-dione hydrochloride
367514-88-3

(3aR,4S,7R,7aS)-2-[((1R,2R)-2-{[4-(l1,2-benzisothiazol-3-yl)piperazin-1-yl]methyl}cyclohexyl)methyl]hexahydro-1H-4,7-methanisoindol-1,3-dione hydrochloride

Conditions
ConditionsYield
Stage #1: (3aR,7aR)-4’-(benzo[d]isothiazol-3-yl)octahydrospiro[isoindole-2,1’-piperazin]-2-ium methanesulfonate; (3aR,4S,7R,7aS)‑4,7‑methylene‑1H‑isoindole‑1,3(2H)-dione With potassium carbonate In toluene at 105℃; for 15h; Industrial scale;
Stage #2: With hydrogenchloride In isopropyl alcohol Industrial scale;
98.3%
Multi-step reaction with 2 steps
1.1: potassium carbonate; dibenzo-18-crown-6 / 5,5-dimethyl-1,3-cyclohexadiene / 3 h
2.1: methanol / 0.17 h / 60 - 65 °C
2.2: 1 h / 60 - 65 °C
View Scheme
C19H26N3S(1+)*CH3O3S(1-)

C19H26N3S(1+)*CH3O3S(1-)

(3aR,4S,7R,7aS)‑4,7‑methylene‑1H‑isoindole‑1,3(2H)-dione
14805-29-9

(3aR,4S,7R,7aS)‑4,7‑methylene‑1H‑isoindole‑1,3(2H)-dione

lurasidone

lurasidone

Conditions
ConditionsYield
With potassium carbonate In water for 10h; Reflux;95%
4-chlorobutyl bromide
6940-78-9

4-chlorobutyl bromide

(3aR,4S,7R,7aS)‑4,7‑methylene‑1H‑isoindole‑1,3(2H)-dione
14805-29-9

(3aR,4S,7R,7aS)‑4,7‑methylene‑1H‑isoindole‑1,3(2H)-dione

(3aR,4S,7R,7aS)-2-(4-chlorobutyl)hexahydro-1H-4,7-methanoisoindole-1,3(2H)-dione

(3aR,4S,7R,7aS)-2-(4-chlorobutyl)hexahydro-1H-4,7-methanoisoindole-1,3(2H)-dione

Conditions
ConditionsYield
With potassium carbonate In N,N-dimethyl-formamide at 0 - 20℃;95%
(3aR,7aR)-4’-(benzo[d]isothiazol-3-yl)octahydrospiro[isoindole-2,1’-piperazin]-2-ium methanesulfonate
186204-37-5

(3aR,7aR)-4’-(benzo[d]isothiazol-3-yl)octahydrospiro[isoindole-2,1’-piperazin]-2-ium methanesulfonate

(3aR,4S,7R,7aS)‑4,7‑methylene‑1H‑isoindole‑1,3(2H)-dione
14805-29-9

(3aR,4S,7R,7aS)‑4,7‑methylene‑1H‑isoindole‑1,3(2H)-dione

lurasidone

lurasidone

Conditions
ConditionsYield
With potassium carbonate In water; toluene for 8h; Product distribution / selectivity; Reflux;94.3%
With tetra(n-butyl)ammonium hydrogensulfate; potassium carbonate In water for 3h; Product distribution / selectivity; Reflux;94.3%
With potassium carbonate In N,N-dimethyl-formamide at 120℃; for 36h; Temperature;91.8%
(3aR,4S,7R,7aS)‑4,7‑methylene‑1H‑isoindole‑1,3(2H)-dione
14805-29-9

(3aR,4S,7R,7aS)‑4,7‑methylene‑1H‑isoindole‑1,3(2H)-dione

propargyl bromide
106-96-7

propargyl bromide

N-Propargylbicyclo<2.2.1>heptane-2,3-di-exo-carboximide
105981-36-0

N-Propargylbicyclo<2.2.1>heptane-2,3-di-exo-carboximide

Conditions
ConditionsYield
With potassium carbonate In acetone for 1h; Heating;91%
1,4-dibromo-butane
110-52-1

1,4-dibromo-butane

(3aR,4S,7R,7aS)‑4,7‑methylene‑1H‑isoindole‑1,3(2H)-dione
14805-29-9

(3aR,4S,7R,7aS)‑4,7‑methylene‑1H‑isoindole‑1,3(2H)-dione

(1R,2S,3R,4S)-N-(4-bromobutyl)-2,3-bicyclo<2.2.1>heptanedicarboximide
99095-09-7

(1R,2S,3R,4S)-N-(4-bromobutyl)-2,3-bicyclo<2.2.1>heptanedicarboximide

Conditions
ConditionsYield
With potassium carbonate In acetone for 7h; Heating;90.2%
(3aR,4S,7R,7aS)‑4,7‑methylene‑1H‑isoindole‑1,3(2H)-dione
14805-29-9

(3aR,4S,7R,7aS)‑4,7‑methylene‑1H‑isoindole‑1,3(2H)-dione

1-chloro-3,4-epoxybutane
13067-79-3

1-chloro-3,4-epoxybutane

(1R,2S,3R,4S)-N-(3,4-epoxybutyl)-2,3-bicyclo<2.2.1>heptanedicarboxamide
105981-37-1

(1R,2S,3R,4S)-N-(3,4-epoxybutyl)-2,3-bicyclo<2.2.1>heptanedicarboxamide

Conditions
ConditionsYield
With potassium carbonate In acetone for 2h; Heating;90.1%
Z-1,4-dichlorobutene
1476-11-5

Z-1,4-dichlorobutene

(3aR,4S,7R,7aS)‑4,7‑methylene‑1H‑isoindole‑1,3(2H)-dione
14805-29-9

(3aR,4S,7R,7aS)‑4,7‑methylene‑1H‑isoindole‑1,3(2H)-dione

N-(4-Chloro-2-cis-butenyl)bicyclo<2.2.1>heptane-2,3-di-exo-carboximide
106035-14-7

N-(4-Chloro-2-cis-butenyl)bicyclo<2.2.1>heptane-2,3-di-exo-carboximide

Conditions
ConditionsYield
With potassium carbonate In N,N-dimethyl-formamide at 90 - 100℃;90%
trans-1,4-dichlorobut-2-ene
110-57-6

trans-1,4-dichlorobut-2-ene

(3aR,4S,7R,7aS)‑4,7‑methylene‑1H‑isoindole‑1,3(2H)-dione
14805-29-9

(3aR,4S,7R,7aS)‑4,7‑methylene‑1H‑isoindole‑1,3(2H)-dione

N-(4-Chloro-2-trans-butenyl)bicyclo<2.2.1>heptane-2,3-di-exo-carboximide
105981-25-7

N-(4-Chloro-2-trans-butenyl)bicyclo<2.2.1>heptane-2,3-di-exo-carboximide

Conditions
ConditionsYield
With potassium carbonate In N,N-dimethyl-formamide at 90 - 100℃; for 2h;88.7%
(3aR,4S,7R,7aS)‑4,7‑methylene‑1H‑isoindole‑1,3(2H)-dione
14805-29-9

(3aR,4S,7R,7aS)‑4,7‑methylene‑1H‑isoindole‑1,3(2H)-dione

8-(1,2-benzisothiazol-3-yl)-2-methyl-8-aza-5-azoniaspiro<4,5>decane methanesulfonate

8-(1,2-benzisothiazol-3-yl)-2-methyl-8-aza-5-azoniaspiro<4,5>decane methanesulfonate

A

(1R,2S,3R,4S)-N-<4-<4-(1,2-benzisothiazol-3-yl)-1-piperazinyl>-2-methylbutyl>-2,3-bicyclo<2.2.1>heptanedicarboximide

(1R,2S,3R,4S)-N-<4-<4-(1,2-benzisothiazol-3-yl)-1-piperazinyl>-2-methylbutyl>-2,3-bicyclo<2.2.1>heptanedicarboximide

B

(1R,2S,3R,4S)-N-<4-<4-(1,2-benzisothiazol-3-yl)-1-piperazinyl>-3-methylbutyl>-2,3-bicyclo<2.2.1>heptanedicarboximide

(1R,2S,3R,4S)-N-<4-<4-(1,2-benzisothiazol-3-yl)-1-piperazinyl>-3-methylbutyl>-2,3-bicyclo<2.2.1>heptanedicarboximide

Conditions
ConditionsYield
With dibenzo-18-crown-6; potassium carbonate In xylene for 10h; Heating;A 17.2%
B 82.7%
(3aR,7aR)-2,2-bis(2-hydroxyethyl)octahydro-1H-isoindolium mesylate
1421374-96-0

(3aR,7aR)-2,2-bis(2-hydroxyethyl)octahydro-1H-isoindolium mesylate

(3aR,4S,7R,7aS)‑4,7‑methylene‑1H‑isoindole‑1,3(2H)-dione
14805-29-9

(3aR,4S,7R,7aS)‑4,7‑methylene‑1H‑isoindole‑1,3(2H)-dione

(3aR,4S,7R,7aS)-2-(((1R,2R)-2-((bis(2-hydroxyethyl)amino)methyl)cyclohexyl)methyl)hexahydro-1H-4,7-methanoisoindole-1,3(2H)-dione

(3aR,4S,7R,7aS)-2-(((1R,2R)-2-((bis(2-hydroxyethyl)amino)methyl)cyclohexyl)methyl)hexahydro-1H-4,7-methanoisoindole-1,3(2H)-dione

Conditions
ConditionsYield
With potassium carbonate In N,N-dimethyl-formamide at 120℃; for 16h;80%
8-(2-quinolinyl)-8-aza-5-azoniaspiro<4.5>decane bromide
142415-01-8

8-(2-quinolinyl)-8-aza-5-azoniaspiro<4.5>decane bromide

(3aR,4S,7R,7aS)‑4,7‑methylene‑1H‑isoindole‑1,3(2H)-dione
14805-29-9

(3aR,4S,7R,7aS)‑4,7‑methylene‑1H‑isoindole‑1,3(2H)-dione

(1S,2R,6S,7R)-4-[4-(4-Quinolin-2-yl-piperazin-1-yl)-butyl]-4-aza-tricyclo[5.2.1.02,6]decane-3,5-dione

(1S,2R,6S,7R)-4-[4-(4-Quinolin-2-yl-piperazin-1-yl)-butyl]-4-aza-tricyclo[5.2.1.02,6]decane-3,5-dione

Conditions
ConditionsYield
With potassium carbonate; 18-crown-6 ether In xylene for 6h; Heating;76%
4-(3,4-Epoxybutyl)-1-(2-pyrimidinyl)piperazine
138274-13-2

4-(3,4-Epoxybutyl)-1-(2-pyrimidinyl)piperazine

(3aR,4S,7R,7aS)‑4,7‑methylene‑1H‑isoindole‑1,3(2H)-dione
14805-29-9

(3aR,4S,7R,7aS)‑4,7‑methylene‑1H‑isoindole‑1,3(2H)-dione

(1R*,2S*,3R*,4S*)-N-<2-Hydroxy-4-<4-(2-pyrimidinyl)-1-piperazinyl>butyl>-2,3-bicyclo<2.2.1>heptanedicarboximide
138273-99-1

(1R*,2S*,3R*,4S*)-N-<2-Hydroxy-4-<4-(2-pyrimidinyl)-1-piperazinyl>butyl>-2,3-bicyclo<2.2.1>heptanedicarboximide

Conditions
ConditionsYield
With potassium carbonate In butan-1-ol for 6h; Heating;59%
(3aR,4S,7R,7aS)‑4,7‑methylene‑1H‑isoindole‑1,3(2H)-dione
14805-29-9

(3aR,4S,7R,7aS)‑4,7‑methylene‑1H‑isoindole‑1,3(2H)-dione

3-<4-(3,4-epoxybutyl)-1-piperazinyl>-1,2-benzisothiazole

3-<4-(3,4-epoxybutyl)-1-piperazinyl>-1,2-benzisothiazole

(1R,2S,3R,4S)-N-<4-<4-(1,2-benzisothiazol-3-yl)-1-piperazinyl>-2-hydroxybutyl>-2,3-bicyclo<2.2.1>heptanedicarboximide

(1R,2S,3R,4S)-N-<4-<4-(1,2-benzisothiazol-3-yl)-1-piperazinyl>-2-hydroxybutyl>-2,3-bicyclo<2.2.1>heptanedicarboximide

Conditions
ConditionsYield
With potassium carbonate In butan-1-ol for 9h; Heating;47.7%
C21H29N3O5S2

C21H29N3O5S2

(3aR,4S,7R,7aS)‑4,7‑methylene‑1H‑isoindole‑1,3(2H)-dione
14805-29-9

(3aR,4S,7R,7aS)‑4,7‑methylene‑1H‑isoindole‑1,3(2H)-dione

C29H36N4O4S

C29H36N4O4S

Conditions
ConditionsYield
With potassium carbonate In N,N-dimethyl-formamide at 133℃; for 2h; Molecular sieve;42%
1,4-dibromo-butane
110-52-1

1,4-dibromo-butane

N-(2-pyridinyl)piperazine
20980-22-7

N-(2-pyridinyl)piperazine

(3aR,4S,7R,7aS)‑4,7‑methylene‑1H‑isoindole‑1,3(2H)-dione
14805-29-9

(3aR,4S,7R,7aS)‑4,7‑methylene‑1H‑isoindole‑1,3(2H)-dione

tandospirone
87760-53-0

tandospirone

Conditions
ConditionsYield
With potassium carbonate; benzyltriethylammonium bromide 1.) toluene, reflux, 4 h, 2.) reflux, 5 h; Yield given. Multistep reaction;
8-(2-Pyrimidinyl)-8-aza-5-azoniaspiro[4.5]decane Bromide
81461-73-6

8-(2-Pyrimidinyl)-8-aza-5-azoniaspiro[4.5]decane Bromide

(3aR,4S,7R,7aS)‑4,7‑methylene‑1H‑isoindole‑1,3(2H)-dione
14805-29-9

(3aR,4S,7R,7aS)‑4,7‑methylene‑1H‑isoindole‑1,3(2H)-dione

tandospirone
87760-53-0

tandospirone

Conditions
ConditionsYield
With potassium carbonate; 18-crown-6 ether In xylene for 6h; Heating;
(3aR,4S,7R,7aS)‑4,7‑methylene‑1H‑isoindole‑1,3(2H)-dione
14805-29-9

(3aR,4S,7R,7aS)‑4,7‑methylene‑1H‑isoindole‑1,3(2H)-dione

(1S,2R,6S,7R)-4-{4-[4-(3-Chloro-pyridin-2-yl)-piperazin-1-yl]-butyl}-4-aza-tricyclo[5.2.1.02,6]decane-3,5-dione
106708-43-4

(1S,2R,6S,7R)-4-{4-[4-(3-Chloro-pyridin-2-yl)-piperazin-1-yl]-butyl}-4-aza-tricyclo[5.2.1.02,6]decane-3,5-dione

Conditions
ConditionsYield
Multi-step reaction with 2 steps
1: 90.2 percent / K2CO3 / acetone / 7 h / Heating
2: K2CO3, KI / acetonitrile / 8 h / Heating
View Scheme
Multi-step reaction with 2 steps
1: 90.2 percent / K2CO3 / acetone / 7 h / Heating
2: 34 percent / K2CO3, KI / dimethylformamide / 90 °C
View Scheme
(3aR,4S,7R,7aS)‑4,7‑methylene‑1H‑isoindole‑1,3(2H)-dione
14805-29-9

(3aR,4S,7R,7aS)‑4,7‑methylene‑1H‑isoindole‑1,3(2H)-dione

(1R*,2S*,6R*,7S*)-5-hydroxy-4-<4-<4-(1,2-benzisothiazol-3-yl)-1-piperazinyl>butyl>-4-azatricyclo<5.2.1.02,6>decan-3-one

(1R*,2S*,6R*,7S*)-5-hydroxy-4-<4-<4-(1,2-benzisothiazol-3-yl)-1-piperazinyl>butyl>-4-azatricyclo<5.2.1.02,6>decan-3-one

Conditions
ConditionsYield
Multi-step reaction with 3 steps
1: 90.2 percent / K2CO3 / acetone / 7 h / Heating
2: K2CO3, KI / acetonitrile / 8 h / Heating
3: 63 percent / NaBH4, 0.1percent aq. NaOH / propan-2-ol / 2 h / Heating
View Scheme
(3aR,4S,7R,7aS)‑4,7‑methylene‑1H‑isoindole‑1,3(2H)-dione
14805-29-9

(3aR,4S,7R,7aS)‑4,7‑methylene‑1H‑isoindole‑1,3(2H)-dione

(1R,2S,3R,4S)-N-<4-<4-(1,2-benzisothiazol-3-yl)-1-piperazinyl>-3-hydroxybutyl>-2,3-bicyclo<2.2.1>heptanedicarboximide

(1R,2S,3R,4S)-N-<4-<4-(1,2-benzisothiazol-3-yl)-1-piperazinyl>-3-hydroxybutyl>-2,3-bicyclo<2.2.1>heptanedicarboximide

Conditions
ConditionsYield
Multi-step reaction with 2 steps
1: 90.1 percent / K2CO3 / acetone / 2 h / Heating
2: 80.7 percent / butan-1-ol / 12 h / Heating
View Scheme
(3aR,4S,7R,7aS)‑4,7‑methylene‑1H‑isoindole‑1,3(2H)-dione
14805-29-9

(3aR,4S,7R,7aS)‑4,7‑methylene‑1H‑isoindole‑1,3(2H)-dione

(1S,2R,6S,7R)-4-[4-(4-Oxo-1-phenyl-1,3,8-triaza-spiro[4.5]dec-8-yl)-butyl]-4-aza-tricyclo[5.2.1.02,6]decane-3,5-dione

(1S,2R,6S,7R)-4-[4-(4-Oxo-1-phenyl-1,3,8-triaza-spiro[4.5]dec-8-yl)-butyl]-4-aza-tricyclo[5.2.1.02,6]decane-3,5-dione

Conditions
ConditionsYield
Multi-step reaction with 2 steps
1: 90.2 percent / K2CO3 / acetone / 7 h / Heating
2: K2CO3, KI / acetonitrile / 8 h / Heating
View Scheme
(3aR,4S,7R,7aS)‑4,7‑methylene‑1H‑isoindole‑1,3(2H)-dione
14805-29-9

(3aR,4S,7R,7aS)‑4,7‑methylene‑1H‑isoindole‑1,3(2H)-dione

(1S,2R,6S,7R)-4-{4-[4-(4-Chloro-phenyl)-4-hydroxy-piperidin-1-yl]-butyl}-4-aza-tricyclo[5.2.1.02,6]decane-3,5-dione

(1S,2R,6S,7R)-4-{4-[4-(4-Chloro-phenyl)-4-hydroxy-piperidin-1-yl]-butyl}-4-aza-tricyclo[5.2.1.02,6]decane-3,5-dione

Conditions
ConditionsYield
Multi-step reaction with 2 steps
1: 90.2 percent / K2CO3 / acetone / 7 h / Heating
2: 62.5 percent / K2CO3, KI / acetonitrile / 8 h / Heating
View Scheme
(3aR,4S,7R,7aS)‑4,7‑methylene‑1H‑isoindole‑1,3(2H)-dione
14805-29-9

(3aR,4S,7R,7aS)‑4,7‑methylene‑1H‑isoindole‑1,3(2H)-dione

(1R,2S,3R,4S)-N-<4-<4-(1,2-benzisothiazol-3-yl)-1-piperazinyl>butyl>-2,3-bicyclo<2.2.1>heptanedicarboximide
106035-20-5

(1R,2S,3R,4S)-N-<4-<4-(1,2-benzisothiazol-3-yl)-1-piperazinyl>butyl>-2,3-bicyclo<2.2.1>heptanedicarboximide

Conditions
ConditionsYield
Multi-step reaction with 2 steps
1: 90.2 percent / K2CO3 / acetone / 7 h / Heating
2: K2CO3, KI / acetonitrile / 8 h / Heating
View Scheme
(3aR,4S,7R,7aS)‑4,7‑methylene‑1H‑isoindole‑1,3(2H)-dione
14805-29-9

(3aR,4S,7R,7aS)‑4,7‑methylene‑1H‑isoindole‑1,3(2H)-dione

(1S,2R,6S,7R)-4-{4-[4-(2-Oxo-2,3-dihydro-benzoimidazol-1-yl)-piperidin-1-yl]-butyl}-4-aza-tricyclo[5.2.1.02,6]decane-3,5-dione

(1S,2R,6S,7R)-4-{4-[4-(2-Oxo-2,3-dihydro-benzoimidazol-1-yl)-piperidin-1-yl]-butyl}-4-aza-tricyclo[5.2.1.02,6]decane-3,5-dione

Conditions
ConditionsYield
Multi-step reaction with 2 steps
1: 90.2 percent / K2CO3 / acetone / 7 h / Heating
2: 66.4 percent / K2CO3, KI / acetonitrile / 8 h / Heating
View Scheme
(3aR,4S,7R,7aS)‑4,7‑methylene‑1H‑isoindole‑1,3(2H)-dione
14805-29-9

(3aR,4S,7R,7aS)‑4,7‑methylene‑1H‑isoindole‑1,3(2H)-dione

N-<4-(3-Methyl-1-piperazinyl)butyl>bicyclo<2.2.1>heptane-2,3-di-exo-carboximide
138274-11-0

N-<4-(3-Methyl-1-piperazinyl)butyl>bicyclo<2.2.1>heptane-2,3-di-exo-carboximide

Conditions
ConditionsYield
Multi-step reaction with 2 steps
1: 90.2 percent / K2CO3 / acetone / 7 h / Heating
2: 100 percent / ethanol / Ambient temperature
View Scheme

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