As a leading and professional manufacturer of APIs and API intermediates in China,Anhui Dexinjia Biopharm Co., Ltd founded in 2006, Except for the R&D center, our company has built a close cooperation relation with Chinese Academy of Sciences,
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inquiryProduct name:Mirabegron Cas No:223673-61-8 Appearance: white powder Assay:99%min Hangzhou Verychem Science And Technology Co. Ltd. was set up in year 2004, it’s a young but fast gro
we are professional Pharmaceutical company. We are specialized in manufacturing and R&D of API & Intermediates, Contract Manufacturing, Contract Research, and International Trading business as well. *We own a R&D center in Hangzhou. I
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inquiry1. GMP AVALIABLE ; 2. IN STOCK 3. FAST REPLY QUALIFED ; EFFICIENCY; RESPONSIBLE Appearance:white crystalline powder Storage:in cool Package:as request Application:active pharmaceutical ingredient Transportation:Air / SEA BOTH OK Port:
As a leading manufacturer and supplier of chemicals in China, DayangChem not only supply popular chemicals, but also DayangChem's R&D center offer custom synthesis services. DayangChem can provide different quantities of custom synthesis ch
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inquiryMirabegron CAS: 223673-61-8 Produced under GMP management CEP certified High assay 99%up Low impurity: Single impurity 0.1% below. Total impurity 0.3%below Produce frequently and export commercially. Appearance:White or yellowish powder Stor
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inquiryItems Standard Result Assay (Ursolic acid) 98%min 98.22% ----------------------------------------------------------------
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inquiryWelcome to Simagchem, your partner in China as a premier supply of bulk specialty chemicals for industry and life science. We introduce experienced quality product and exceptional JIT service with instant market intelligence in China to benefit our
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inquirySpecifications CAS No.: 223673-61-8 Other Names: Mirabegron MF: C21H24N4O2S EINECS No.: NA Place of Origin: Shaanxi, China (Mainland
hebei yanxi chemical co., LTD who registered capital of 10 million yuan, nearly to $2 million, we have a pharmaceutical raw materials factory production of pharmaceutical raw materials, and a reagent r&d center, and we do research and developm
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inquiryUnique advantages for Mirabegron CAS 223673-61-8 High quality & competitive price Quality control Fast feedback Prompt shipment Appearance:White powder Storage:-20°C Freezer Package:1g,10g,100g,1kg/foil bag Application:Adrenergic Receptor ago
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inquiryMirabegron[CAS:223673-61-8] AlphaR-Alpha-Hydroxy-N-[2-(4-Nitrophenyl Ethyl Benzeneacetamide[CAS:521284-19-5] HANGZHOU THINK CHEMICAL CO., LTD. (THINKCHEM) is an integrative corporation of trade, research and contract manufacture.
The above product is Ality Chemical's strong item with best price, good quality and fast supply. Ality Chemical has been focusing on the research and production of this field for over 14 years. At the same time, we are always committed to providi
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inquiry1. Factory price and high quality must be guaranteed, base on 8 years of production and R&D experience2. Free samples will be provided,ensure specifications and quality are right for customer3. Customers will receive the most professional technical s
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inquiryCangzhou Enke Pharma Tech Co.,ltd. is located in Cangzhou City, Hebei province ,where is a famous petroleum chemical industry city in China. Enke Pharma a high-tech enterprise ,and we are dedicated to developing and manufacturing new ap
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inquiryOur advantages: 1. High quality and competitive price: 1) Standard: BP/USP/EP/ enterprise standard 2) All purity ≥99% 3) We are manufacturers and can provide high quality products at factory prices. 2. Fast and safe delivery 1) The package c
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inquiryCAS:223673-61-8 MF:C21H24N4O2S MW:396.50 Density:1.313 storage temp.-20°C Freezer Refractive index:1.68 Appearance:White to off-white powder Purity:More than 99.0% Usage:Potent bladder relaxant an
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inquiryHanways chempharm is a specialized company concentrating on the R&D, production, marketing and technical service of APIs and pharmaceutical intermediates. The marketing department is located in Wuhan. We have two GMP facilities in Hubei Pr
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Cas:223673-61-8
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inquiryMirabegron CAS: 223673-61-8 Qingdao Belugas Import and Export Co., Ltd. is a scientific and technological company integrating research and development, production and trade of chemical intermediates, specializing in high quality organic intermediate
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inquiry(R)-2-(2-aminothiazol-4-yl)-4'-[2-[(2-hydroxy-2-phenylethyl)amino]ethyl]acetanilide
Conditions | Yield |
---|---|
With water In water at 80℃; for 24h; Reagent/catalyst; Temperature; | 100% |
2-amino-4-thiazoleacetic acid
YM-208876
(R)-2-(2-aminothiazol-4-yl)-4'-[2-[(2-hydroxy-2-phenylethyl)amino]ethyl]acetanilide
Conditions | Yield |
---|---|
Stage #1: 2-amino-4-thiazoleacetic acid; YM-208876 In water at 20℃; for 0.0833333h; Stage #2: With hydrogenchloride; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride In water at 20℃; for 1h; Reagent/catalyst; Temperature; | 92.6% |
With hydrogenchloride; 1,2-dichloro-ethane In water at 30℃; for 5h; | 88.31% |
With N-ethyl-N,N-diisopropylamine; N-[(dimethylamino)-3-oxo-1H-1,2,3-triazolo[4,5-b]pyridin-1-yl-methylene]-N-methylmethanaminium hexafluorophosphate In d7-N,N-dimethylformamide at 25℃; for 13h; Reagent/catalyst; | 84% |
With hydrogenchloride; dmap In water at 20℃; for 6h; | 79% |
Stage #1: 2-amino-4-thiazoleacetic acid; YM-208876 With hydrogenchloride In water at 25 - 30℃; for 0.25h; Stage #2: With 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride at 25 - 30℃; Stage #3: With sodium hydroxide In water at 0 - 5℃; pH=9; | 144 g |
2-amino-4-thiazoleacetic acid
(R)-2-(2-aminothiazol-4-yl)-4'-[2-[(2-hydroxy-2-phenylethyl)amino]ethyl]acetanilide
Conditions | Yield |
---|---|
With hydrogenchloride; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride In water at 15 - 20℃; for 1h; pH=1.8 - 2; | 92% |
With 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride In water at 20 - 25℃; for 4h; Concentration; | 82% |
With hydrogenchloride; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride In water for 1h; |
(R)-2-(2-aminothiazol-4-yl)-4'-[2-[(2-hydroxy-2-phenylethyl)amino]ethyl]acetanilide
Conditions | Yield |
---|---|
With hydrogenchloride In 1,4-dioxane; water at 20℃; for 10h; | 90.3% |
2-amino-4-thiazoleacetic acid
(R)-2-[ [2-(4-aminophenyl)ethyl]-amino]-1-phenylethanol monohydrochloride
(R)-2-(2-aminothiazol-4-yl)-4'-[2-[(2-hydroxy-2-phenylethyl)amino]ethyl]acetanilide
Conditions | Yield |
---|---|
With hydrogenchloride; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride In water at 28℃; for 3h; Concentration; | 84.5% |
Stage #1: 2-amino-4-thiazoleacetic acid; (R)-2-[ [2-(4-aminophenyl)ethyl]-amino]-1-phenylethanol monohydrochloride With hydrogenchloride In water at 25 - 30℃; Stage #2: With 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride In water at 25 - 30℃; for 2h; | 84% |
Stage #1: 2-amino-4-thiazoleacetic acid; (R)-2-[ [2-(4-aminophenyl)ethyl]-amino]-1-phenylethanol monohydrochloride With hydrogenchloride; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride In water at 15 - 20℃; for 1h; Stage #2: With sodium hydroxide In water |
(R)-2-(2-aminothiazol-4-yl)-4'-[2-[(2-hydroxy-2-phenylethyl)amino]ethyl]acetanilide
Conditions | Yield |
---|---|
With hydrazine hydrate In ethanol for 3h; Reflux; | 84% |
With hydrazine hydrate In ethanol for 3h; Reflux; | 84% |
2-amino-4-thiazoleacetic acid
(R)-2-(2-aminothiazol-4-yl)-4'-[2-[(2-hydroxy-2-phenylethyl)amino]ethyl]acetanilide
Conditions | Yield |
---|---|
With hydrogenchloride; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride In water at 20℃; for 1h; | 75.7% |
YM-208876
(R)-2-(2-aminothiazol-4-yl)-4'-[2-[(2-hydroxy-2-phenylethyl)amino]ethyl]acetanilide
Conditions | Yield |
---|---|
With potassium carbonate In acetone at 10 - 15℃; | 70% |
(R)-2-(2-aminothiazol-4-yl)-4'-[2-[(2-hydroxy-2-phenylethyl)amino]ethyl]acetanilide
Conditions | Yield |
---|---|
With sodium hydroxide at 55 - 60℃; for 3h; | 70% |
(R)-2-(2-aminothiazol-4-yl)-4'-[2-[(2-hydroxy-2-phenylethyl)amino]ethyl]acetanilide
Conditions | Yield |
---|---|
With sodium hydroxide In 2-methyltetrahydrofuran; water pH=9; | 63% |
(R)-2-(2-aminothiazol-4-yl)-4'-[2-[(2-hydroxy-2-phenylethyl)amino]ethyl]acetanilide
Conditions | Yield |
---|---|
With sodium hydroxide In 2-methyltetrahydrofuran; water pH=9; | 63% |
(R)-2-(2-aminothiazol-4-yl)-4'-[2-[(2-hydroxy-2-phenylethyl)amino]ethyl]acetanilide
Conditions | Yield |
---|---|
With sodium hydroxide In 2-methyltetrahydrofuran; water pH=9; | 52% |
YM-208876
(R)-2-(2-aminothiazol-4-yl)-4'-[2-[(2-hydroxy-2-phenylethyl)amino]ethyl]acetanilide
Conditions | Yield |
---|---|
Stage #1: 2-(2-aminothiazol-4-yl)acetic acid hydrochloride; YM-208876 With hydrogenchloride In water at 25 - 30℃; for 0.25h; Stage #2: With 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride at 25 - 30℃; Stage #3: With sodium hydroxide In water at 0 - 5℃; pH=9; | 43 g |
(R)-2-(2-aminothiazol-4-yl)-4'-[2-[(2-hydroxy-2-phenylethyl)amino]ethyl]acetanilide
Conditions | Yield |
---|---|
With sodium hydroxide In water at 25 - 30℃; | 43 mg |
4-tert-butoxycarbonylaminophenylacetonitrile
(R)-2-(2-aminothiazol-4-yl)-4'-[2-[(2-hydroxy-2-phenylethyl)amino]ethyl]acetanilide
Conditions | Yield |
---|---|
Multi-step reaction with 5 steps 1.1: hydrogen; ammonia / water; methanol / 4 h / 25 - 30 °C / 2585.81 - 3102.97 Torr 2.1: dicyclohexyl-carbodiimide; benzotriazol-1-ol / 2-methyltetrahydrofuran / 2 h / 25 - 30 °C 3.1: hydrogenchloride / water; ethyl acetate / 4 h / 20 °C 4.1: sodium hydroxide / water / 10 - 15 °C / pH 9 - 10 4.2: 4 h / 5 - 65 °C / Inert atmosphere 4.3: 0.5 h / 5 - 10 °C 5.1: hydrogenchloride; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride / water / 1 h / 15 - 20 °C / pH 1.8 - 2 View Scheme |
4-(2-aminoethyl)-N-(tert-butoxycarbonyl)phenylamine
(R)-2-(2-aminothiazol-4-yl)-4'-[2-[(2-hydroxy-2-phenylethyl)amino]ethyl]acetanilide
Conditions | Yield |
---|---|
Multi-step reaction with 4 steps 1.1: dicyclohexyl-carbodiimide; benzotriazol-1-ol / 2-methyltetrahydrofuran / 2 h / 25 - 30 °C 2.1: hydrogenchloride / water; ethyl acetate / 4 h / 20 °C 3.1: sodium hydroxide / water / 10 - 15 °C / pH 9 - 10 3.2: 4 h / 5 - 65 °C / Inert atmosphere 3.3: 0.5 h / 5 - 10 °C 4.1: hydrogenchloride; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride / water / 1 h / 15 - 20 °C / pH 1.8 - 2 View Scheme |
(R)-2-(2-aminothiazol-4-yl)-4'-[2-[(2-hydroxy-2-phenylethyl)amino]ethyl]acetanilide
Conditions | Yield |
---|---|
Multi-step reaction with 3 steps 1.1: hydrogenchloride / water; ethyl acetate / 4 h / 20 °C 2.1: sodium hydroxide / water / 10 - 15 °C / pH 9 - 10 2.2: 4 h / 5 - 65 °C / Inert atmosphere 2.3: 0.5 h / 5 - 10 °C 3.1: hydrogenchloride; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride / water / 1 h / 15 - 20 °C / pH 1.8 - 2 View Scheme |
4-Nitrophenylacetonitrile
(R)-2-(2-aminothiazol-4-yl)-4'-[2-[(2-hydroxy-2-phenylethyl)amino]ethyl]acetanilide
Conditions | Yield |
---|---|
Multi-step reaction with 7 steps 1.1: hydrogen; palladium 10% on activated carbon / ethyl acetate / 20 - 25 °C / 2585.81 - 3102.97 Torr 2.1: ethyl acetate / 25 - 30 °C 3.1: hydrogen; ammonia / water; methanol / 4 h / 25 - 30 °C / 2585.81 - 3102.97 Torr 4.1: dicyclohexyl-carbodiimide; benzotriazol-1-ol / 2-methyltetrahydrofuran / 2 h / 25 - 30 °C 5.1: hydrogenchloride / water; ethyl acetate / 4 h / 20 °C 6.1: sodium hydroxide / water / 10 - 15 °C / pH 9 - 10 6.2: 4 h / 5 - 65 °C / Inert atmosphere 6.3: 0.5 h / 5 - 10 °C 7.1: hydrogenchloride; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride / water / 1 h / 15 - 20 °C / pH 1.8 - 2 View Scheme | |
Multi-step reaction with 4 steps 1: hydrazine; palladium 10% on activated carbon / ethanol / 2 h / 25 °C / Inert atmosphere 2: hydrazine / 5 h / 25 - 60 °C / Inert atmosphere 3: acetonitrile / 10 h / 70 °C 4: N-[(dimethylamino)-3-oxo-1H-1,2,3-triazolo[4,5-b]pyridin-1-yl-methylene]-N-methylmethanaminium hexafluorophosphate; N-ethyl-N,N-diisopropylamine / d7-N,N-dimethylformamide / 13 h / 25 °C View Scheme | |
Multi-step reaction with 4 steps 1.1: diisobutylaluminium hydride / toluene / 2 h / 0 - 10 °C / Inert atmosphere 2.1: triethylamine / methanol / 2 h / 20 °C / Inert atmosphere 2.2: 1 h / 0 °C / Inert atmosphere 3.1: ammonium formate; palladium on activated charcoal / methanol / 6 h / 50 °C 4.1: hydrogenchloride; dmap / water / 6 h / 20 °C View Scheme |
phenylacetonitrile
(R)-2-(2-aminothiazol-4-yl)-4'-[2-[(2-hydroxy-2-phenylethyl)amino]ethyl]acetanilide
Conditions | Yield |
---|---|
Multi-step reaction with 8 steps 1.1: nitric acid; phosphoric acid / water / 2 h / 0 - 25 °C 2.1: hydrogen; palladium 10% on activated carbon / ethyl acetate / 20 - 25 °C / 2585.81 - 3102.97 Torr 3.1: ethyl acetate / 25 - 30 °C 4.1: hydrogen; ammonia / water; methanol / 4 h / 25 - 30 °C / 2585.81 - 3102.97 Torr 5.1: dicyclohexyl-carbodiimide; benzotriazol-1-ol / 2-methyltetrahydrofuran / 2 h / 25 - 30 °C 6.1: hydrogenchloride / water; ethyl acetate / 4 h / 20 °C 7.1: sodium hydroxide / water / 10 - 15 °C / pH 9 - 10 7.2: 4 h / 5 - 65 °C / Inert atmosphere 7.3: 0.5 h / 5 - 10 °C 8.1: hydrogenchloride; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride / water / 1 h / 15 - 20 °C / pH 1.8 - 2 View Scheme |
p-aminophenylacetonitrile
(R)-2-(2-aminothiazol-4-yl)-4'-[2-[(2-hydroxy-2-phenylethyl)amino]ethyl]acetanilide
Conditions | Yield |
---|---|
Multi-step reaction with 6 steps 1.1: ethyl acetate / 25 - 30 °C 2.1: hydrogen; ammonia / water; methanol / 4 h / 25 - 30 °C / 2585.81 - 3102.97 Torr 3.1: dicyclohexyl-carbodiimide; benzotriazol-1-ol / 2-methyltetrahydrofuran / 2 h / 25 - 30 °C 4.1: hydrogenchloride / water; ethyl acetate / 4 h / 20 °C 5.1: sodium hydroxide / water / 10 - 15 °C / pH 9 - 10 5.2: 4 h / 5 - 65 °C / Inert atmosphere 5.3: 0.5 h / 5 - 10 °C 6.1: hydrogenchloride; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride / water / 1 h / 15 - 20 °C / pH 1.8 - 2 View Scheme | |
Multi-step reaction with 3 steps 1: hydrazine / 5 h / 25 - 60 °C / Inert atmosphere 2: acetonitrile / 10 h / 70 °C 3: N-[(dimethylamino)-3-oxo-1H-1,2,3-triazolo[4,5-b]pyridin-1-yl-methylene]-N-methylmethanaminium hexafluorophosphate; N-ethyl-N,N-diisopropylamine / d7-N,N-dimethylformamide / 13 h / 25 °C View Scheme |
[2-(formylamino)-1,3-thiazol-4-yl]acetyl chloride
(R)-2-(2-aminothiazol-4-yl)-4'-[2-[(2-hydroxy-2-phenylethyl)amino]ethyl]acetanilide
Conditions | Yield |
---|---|
Multi-step reaction with 2 steps 1: potassium carbonate / acetonitrile / 10 - 15 °C 2: sodium hydroxide / 3 h / 55 - 60 °C View Scheme | |
Multi-step reaction with 3 steps 1: potassium carbonate / dichloromethane / 10 - 15 °C 2: potassium carbonate / dichloromethane / 1 h / 25 - 30 °C 3: sodium hydroxide / 3 h / 55 - 60 °C View Scheme |
(R)-2-(2-aminothiazol-4-yl)-4'-[2-[(2-hydroxy-2-phenylethyl)amino]ethyl]acetanilide
Conditions | Yield |
---|---|
Multi-step reaction with 3 steps 1: phosphorus pentachloride / dichloromethane / -10 °C 2: potassium carbonate / acetonitrile / 10 - 15 °C 3: sodium hydroxide / 3 h / 55 - 60 °C View Scheme | |
Multi-step reaction with 4 steps 1: phosphorus pentachloride / dichloromethane / -10 °C 2: potassium carbonate / dichloromethane / 10 - 15 °C 3: potassium carbonate / dichloromethane / 1 h / 25 - 30 °C 4: sodium hydroxide / 3 h / 55 - 60 °C View Scheme |
YM-208876
(R)-2-(2-aminothiazol-4-yl)-4'-[2-[(2-hydroxy-2-phenylethyl)amino]ethyl]acetanilide
Conditions | Yield |
---|---|
Multi-step reaction with 2 steps 1: 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; hydrogenchloride / water / 0.5 h / 25 - 30 °C 2: sodium hydroxide / 3 h / 55 - 60 °C View Scheme |
(R)-2-(2-aminothiazol-4-yl)-4'-[2-[(2-hydroxy-2-phenylethyl)amino]ethyl]acetanilide
Conditions | Yield |
---|---|
Multi-step reaction with 2 steps 1: potassium carbonate / dichloromethane / 10 - 15 °C 2: potassium carbonate / dichloromethane / 1 h / 25 - 30 °C View Scheme |
2-amino-4-thiazoleacetic acid
(R)-2-(2-aminothiazol-4-yl)-4'-[2-[(2-hydroxy-2-phenylethyl)amino]ethyl]acetanilide
Conditions | Yield |
---|---|
Multi-step reaction with 2 steps 1: oxalyl dichloride; N,N-dimethyl-formamide / dichloromethane / 0 - 5 °C 2: potassium carbonate / acetone / 10 - 15 °C View Scheme | |
Multi-step reaction with 3 steps 1: oxalyl dichloride; N,N-dimethyl-formamide / dichloromethane / 0 - 5 °C 2: potassium carbonate / dichloromethane / 10 - 15 °C 3: potassium carbonate / dichloromethane / 1 h / 25 - 30 °C View Scheme | |
Multi-step reaction with 2 steps 1.1: 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride / water / 3 h / 20 - 25 °C 1.2: 1 h / 20 - 25 °C 2.1: sodium hydroxide / water; 2-methyltetrahydrofuran / pH 9 View Scheme |
(R)-2-(2-aminothiazol-4-yl)-4'-[2-[(2-hydroxy-2-phenylethyl)amino]ethyl]acetanilide
Conditions | Yield |
---|---|
Multi-step reaction with 2 steps 1: potassium carbonate / dichloromethane / 1 h / 25 - 30 °C 2: sodium hydroxide / 3 h / 55 - 60 °C View Scheme |
YM-208876
(R)-2-(2-aminothiazol-4-yl)-4'-[2-[(2-hydroxy-2-phenylethyl)amino]ethyl]acetanilide
Conditions | Yield |
---|---|
With potassium carbonate In dichloromethane at 25 - 30℃; for 1h; | 1 g |
(R)-Mandelic Acid
(R)-2-(2-aminothiazol-4-yl)-4'-[2-[(2-hydroxy-2-phenylethyl)amino]ethyl]acetanilide
Conditions | Yield |
---|---|
Multi-step reaction with 4 steps 1: triethylamine; benzotriazol-1-ol; 1,2-dichloro-ethane / N,N-dimethyl-formamide / 6 h / 30 °C 2: 1,3-dimethyl-2-imidazolidinone; borane-THF / tetrahydrofuran / 4 h / 70 °C 3: ammonium formate; palladium 10% on activated carbon / methanol / 5 h / 65 °C / Reflux 4: hydrogenchloride; 1,2-dichloro-ethane / water / 5 h / 30 °C View Scheme |
(2R)-2-hydroxy-N-[2-(4-nitrophenyl)ethyl]-2-phenylethanamide
(R)-2-(2-aminothiazol-4-yl)-4'-[2-[(2-hydroxy-2-phenylethyl)amino]ethyl]acetanilide
Conditions | Yield |
---|---|
Multi-step reaction with 3 steps 1: 1,3-dimethyl-2-imidazolidinone; borane-THF / tetrahydrofuran / 4 h / 70 °C 2: ammonium formate; palladium 10% on activated carbon / methanol / 5 h / 65 °C / Reflux 3: hydrogenchloride; 1,2-dichloro-ethane / water / 5 h / 30 °C View Scheme | |
Multi-step reaction with 3 steps 1: hydrogen; palladium 10% on activated carbon / methanol / 4 h / 20 - 25 °C 2: aluminum (III) chloride; lithium aluminium tetrahydride / tetrahydrofuran / 5 h / Reflux 3: hydrogenchloride; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride / water / 1 h / 20 °C View Scheme |
(R)-2-(2-aminothiazol-4-yl)-4'-[2-[(2-hydroxy-2-phenylethyl)amino]ethyl]acetanilide
Conditions | Yield |
---|---|
With hydrogenchloride In isopropyl alcohol at 75℃; for 0.25h; | 99% |
With hydrogenchloride In methanol; isopropyl alcohol at 20 - 25℃; for 3h; | 70 g |
(R)-2-(2-aminothiazol-4-yl)-4'-[2-[(2-hydroxy-2-phenylethyl)amino]ethyl]acetanilide
citric acid
Conditions | Yield |
---|---|
In methanol at 20℃; for 2h; | 94.6% |
(R)-2-(2-aminothiazol-4-yl)-4'-[2-[(2-hydroxy-2-phenylethyl)amino]ethyl]acetanilide
p-Coumaric Acid
Conditions | Yield |
---|---|
In methanol at 20℃; for 2h; | 94.4% |
Hippuric Acid
(R)-2-(2-aminothiazol-4-yl)-4'-[2-[(2-hydroxy-2-phenylethyl)amino]ethyl]acetanilide
Conditions | Yield |
---|---|
In methanol at 20℃; for 2h; | 93.2% |
(R)-2-(2-aminothiazol-4-yl)-4'-[2-[(2-hydroxy-2-phenylethyl)amino]ethyl]acetanilide
(2E)-but-2-enedioic acid
Conditions | Yield |
---|---|
In methanol at 20℃; for 2h; | 93% |
(R)-2-(2-aminothiazol-4-yl)-4'-[2-[(2-hydroxy-2-phenylethyl)amino]ethyl]acetanilide
(2E)-but-2-enedioic acid
Conditions | Yield |
---|---|
In methanol at 15 - 40℃; for 7.83333h; | 90% |
(R)-2-(2-aminothiazol-4-yl)-4'-[2-[(2-hydroxy-2-phenylethyl)amino]ethyl]acetanilide
n-tetradecanoic acid
Conditions | Yield |
---|---|
In methanol at 20℃; for 2h; | 89.2% |
(R)-2-(2-aminothiazol-4-yl)-4'-[2-[(2-hydroxy-2-phenylethyl)amino]ethyl]acetanilide
oxalic acid
Conditions | Yield |
---|---|
In 2-methyltetrahydrofuran at 20 - 25℃; for 1h; | 88% |
(R)-2-(2-aminothiazol-4-yl)-4'-[2-[(2-hydroxy-2-phenylethyl)amino]ethyl]acetanilide
citric acid
Conditions | Yield |
---|---|
In methanol at 15 - 40℃; for 7.83333h; | 88% |
(R)-2-(2-aminothiazol-4-yl)-4'-[2-[(2-hydroxy-2-phenylethyl)amino]ethyl]acetanilide
L-Pyroglutamic acid
Conditions | Yield |
---|---|
In methanol at 15 - 40℃; for 7.83333h; | 86% |
In methanol; acetone at 20℃; for 1h; | 4.2 g |
(R)-2-(2-aminothiazol-4-yl)-4'-[2-[(2-hydroxy-2-phenylethyl)amino]ethyl]acetanilide
Conditions | Yield |
---|---|
With phosphoric acid In methanol at 20℃; for 2h; | 83.9% |
(R)-2-(2-aminothiazol-4-yl)-4'-[2-[(2-hydroxy-2-phenylethyl)amino]ethyl]acetanilide
benzoic acid
Conditions | Yield |
---|---|
In 2-methyltetrahydrofuran at 20 - 25℃; for 1h; | 83% |
(R)-2-(2-aminothiazol-4-yl)-4'-[2-[(2-hydroxy-2-phenylethyl)amino]ethyl]acetanilide
tartaric acid
Conditions | Yield |
---|---|
In 2-methyltetrahydrofuran at 20 - 25℃; for 1h; | 83% |
(R)-2-(2-aminothiazol-4-yl)-4'-[2-[(2-hydroxy-2-phenylethyl)amino]ethyl]acetanilide
Conditions | Yield |
---|---|
With magnesium(II) chloride hexahydrate In butan-1-ol at 85℃; for 0.25h; Solvent; | 79.5% |
(R)-2-(2-aminothiazol-4-yl)-4'-[2-[(2-hydroxy-2-phenylethyl)amino]ethyl]acetanilide
orotic acid
Conditions | Yield |
---|---|
In methanol at 20℃; for 2h; | 79.2% |
(R)-2-(2-aminothiazol-4-yl)-4'-[2-[(2-hydroxy-2-phenylethyl)amino]ethyl]acetanilide
succinic acid
Conditions | Yield |
---|---|
In 2-methyltetrahydrofuran at 20 - 25℃; for 1h; | 79% |
(R)-2-(2-aminothiazol-4-yl)-4'-[2-[(2-hydroxy-2-phenylethyl)amino]ethyl]acetanilide
toluene-4-sulfonic acid
Conditions | Yield |
---|---|
In 2-methyltetrahydrofuran at 20 - 40℃; for 1.5h; | 70% |
(R)-2-(2-aminothiazol-4-yl)-4'-[2-[(2-hydroxy-2-phenylethyl)amino]ethyl]acetanilide
(R)-2-(4-(2-(2-aminothiazol-4-yl)ethylamino)phenethylamino)-1-phenylethanol
Conditions | Yield |
---|---|
Stage #1: (R)-2-(2-aminothiazol-4-yl)-4'-[2-[(2-hydroxy-2-phenylethyl)amino]ethyl]acetanilide With borane-THF In tetrahydrofuran at 0 - 50℃; for 2h; Stage #2: With hydrogenchloride In tetrahydrofuran; water Stage #3: With sodium hydroxide In tetrahydrofuran; water pH=10; | 9% |
Stage #1: (R)-2-(2-aminothiazol-4-yl)-4'-[2-[(2-hydroxy-2-phenylethyl)amino]ethyl]acetanilide With borane-THF In tetrahydrofuran at 0 - 50℃; for 2h; Stage #2: With sodium carbonate In water | 9% |
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