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Hangzhou Dingyan Chem Co., Ltd

Analysis Tests Standard Results Description Yellow solid powder Yellow solid powder Identification

High quality Nintedanib with best price cas:656247-17-5

Cas:656247-17-5

Min.Order:1 Kilogram

FOB Price: $250.0 / 350.0

Type:Manufacturers

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Hangzhou JINLAN Pharm-Drugs Technology Co., Ltd

Jinlan Pharm-Drugs Technology Co.,Limited (with its export company Hangzhou Royall Import & Export Co.,Ltd.)is located in Hangzhou, Zhejiang Province. Neighboring Ningbo port, Shanghai port, Hangzhou Xiaoshan Int’l Airport and Shanghai Pu

Nintedanib 656247-17-5 API

Cas:656247-17-5

Min.Order:1 Metric Ton

Negotiable

Type:Manufacturers

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Hangzhou Think Chemical Co. Ltd

Intedanib CAS No.:656247-17-5 Name: Intedanib Synonyms: Vargatef; BIBF 1120 Molecular Structure Molecular Formula: C31H33N5O4 Molecular Weight: 539.62 CAS Registry

High purity Intedanib CAS No.:656247-17-5

Cas:656247-17-5

Min.Order:1 Kilogram

FOB Price: $2.0

Type:Other

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Ality Chemical Corporation

The above product is Ality Chemical's strong item with best price, good quality and fast supply. Ality Chemical has been focusing on the research and production of this field for over 14 years. At the same time, we are always committed to providi

Factory Supply Intedanib

Cas:656247-17-5

Min.Order:1

Negotiable

Type:Other

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Xi'an Xszo Chem Co., Ltd.

1. Factory price and high quality must be guaranteed, base on 8 years of production and R&D experience2. Free samples will be provided,ensure specifications and quality are right for customer3. Customers will receive the most professional technical s

Factory Price API 99% Nintedanib 656247-17-5 GMP Manufacturer

Cas:656247-17-5

Min.Order:1 Gram

FOB Price: $0.1

Type:Manufacturers

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ANQING CHICO PHARMACEUTICAL CO.,LTD.

Basic information Product Name: Nintedanib Synonyms: Nintedanib;Nintedanib (BIBF 1120);Nintedanib/Intedanib/Vargatef;Intedanib Vargatef;methyl (3Z)-3-[[4-[methyl-[2-(4-methylpiperazin-1-yl)acetyl]amino]anilino]-phenylmethylidene]-2-o

Nintedanib

Cas:656247-17-5

Min.Order:1 Kilogram

Negotiable

Type:Trading Company

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Enke Pharma-tech Co.,Ltd. (Cangzhou, China )

Cangzhou Enke Pharma Tech Co.,ltd. is located in Cangzhou City, Hebei province ,where is a famous petroleum chemical industry city in China. Enke Pharma a high-tech enterprise ,and we are dedicated to developing and manufacturing new ap

Intedanib

Cas:656247-17-5

Min.Order:1 Kilogram

FOB Price: $1.0

Type:Manufacturers

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Dayang Chem (Hangzhou) Co.,Ltd.

DayangChem exported this product to many countries and regions at best price. If you are looking for the material’s manufacturer or supplier in China, DayangChem is your best choice. Pls contact with us freely for getting detailed product s

Nintedanib Manufacturer/High quality/Best price/In stock

Cas:656247-17-5

Min.Order:0 Metric Ton

Negotiable

Type:Lab/Research institutions

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Chemwill Asia Co., Ltd.

Our main production base is located in Xuzhou industry park. We are certified both to the ISO 9001 and ISO 14001 Standards, have a safety management system in place.Our R&D team masters core technology for process-design of target building block

Intedanib

Cas:656247-17-5

Min.Order:5 Kiloliter

FOB Price: $1.2 / 5.0

Type:Manufacturers

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Hebei yanxi chemical co.,LTD.

chengdu and import and export trade co., LTD., who registered capital of 10 million yuan, nearly to $2 million, we have a pharmaceutical raw materials factory production of pharmaceutical raw materials, and a reagent r&d center, and we do res

656247-17-5

Cas:656247-17-5

Min.Order:1000 Gram

FOB Price: $500.0

Type:Trading Company

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Hubei DiBo chemical co., LTD

Name:Nintedanib(BIBF1120) The alias:Intedanib CAS NO: 656247-17-5 Molecular formula:C31H33N5O4 Molecular weight:539.62 Product Quality 12 years of chemical raw materials Mature operation of the industry System stability Data storage Sec

Nintedanib/CAS:656247-17-5/Raw material supply

Cas:656247-17-5

Min.Order:25 Kilogram

FOB Price: $1.0 / 2.0

Type:Other

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Henan Tianfu Chemical Co., Ltd.

Our company was built in 2009 with an ISO certificate.In the past 6 years, we have grown up as a famous fine chemicals supplier in China and we had established stable business relationships with Samsung,LG,Merck,Thermo Fisher Scientific and so on.O

656247-17-5 Nintedanib

Cas:656247-17-5

Min.Order:1 Kilogram

FOB Price: $1000.0

Type:Lab/Research institutions

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LIDE PHARMACEUTICALS LIMITED

LIDE PHARMACEUTICALS LIMITED is a professional chemicals and APIs leading manufacturer in China. Our core business line covers APIs, Intermediates, Herb extract, etc.

Intedanib

Cas:656247-17-5

Min.Order:1 Kilogram

FOB Price: $0.9 / 1.0

Type:Lab/Research institutions

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Zhuozhou Wenxi import and Export Co., Ltd

WITH US,YOUR MONEY IN SAFE,YOUR BUSINESS IN SAFE 1)Quick Response Within 12 hours; 2)Quality Guarantee: All products are strictly tested by our QC, confirmed by QA and approved by third party lab in China, USA, Canada, Germany, UK, Italy, France et

Pharmaceutical Grade CAS 656247-17-5 with competitive price

Cas:656247-17-5

Min.Order:1 Kilogram

FOB Price: $139.0 / 210.0

Type:Trading Company

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Wuhan Han Sheng New Material Technology Co.,Ltd

Our Advantage: high quality with competitive price High quality standard: BP/USP/EP Enterprise standard All purity customized Fast and safe delivery We have reliable forwarder who can help us deliver our goods more fast and safe. We

Nintedanib BIBF 1120 Imidafenacin 656247-17-5

Cas:656247-17-5

Min.Order:10 Kilogram

Negotiable

Type:Trading Company

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Hebei Sankai Chemical Technology Co., Ltd

1. Product advantages High purity, all above 98.5%, no impurities after dissolution We will test each batch to ensure quality OEM and private brand services designed for free Various cap colors available We can also provide MT1 peptide powd

Nintedanib

Cas:656247-17-5

Min.Order:1 Kilogram

FOB Price: $50.0 / 100.0

Type:Trading Company

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Henan Sinotech Import&Export Corporation

Product name Methyl (Z)-3-(((4-(N-methyl-2-(4-methylpiperazin-1-yl)acetamido)phenyl)amino)(phenyl)methylene)-2-oxoindoline-6-carboxylate ethanesulfonate CAS NO. 656247-17-5 Molecular Formula C33H39N5O7S

Hubei Langyou International Trading Co., Ltd

1. Guaranteed purity; 2. Large quantity in stock; 3. Largest manufacturer; 4. Best service after shipment with email; 5. High quality & competitive price; Appearance:White Crystalline Powder Storage:Store in sealed conta

Shanghai Upbio Tech Co.,Ltd

1.No Less 8 years exporting experience. Clients can 100% received goods 2.Lower Price with higher quality 3,Free sample 4,We are sincerely responsible for the "product quality" and "After Service" Upbio is Specialized

Intedanib 656247-17-5

Cas:656247-17-5

Min.Order:1 Kilogram

Negotiable

Type:Lab/Research institutions

inquiry

Baoji Guokang Healthchem co.,ltd

Our company has been in existence for 10 years since its establishment. We have our own unique team. The company integrates independent research and development, production and sales. We have established famous brands at home and abroad. At present

Nintedanib

Cas:656247-17-5

Min.Order:1 Gram

FOB Price: $700.0

Type:Trading Company

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Qingdao Beluga Import and Export Co., LTD

Qingdao Belugas Import and Export Co., Ltd. is a scientific and technological company integrating research and development, production and trade of chemical intermediates, specializing in high quality organic intermediates, steroids, pharmaceutical

Nintedanib/656247-17-5

Cas:656247-17-5

Min.Order:10 Gram

Negotiable

Type:Lab/Research institutions

inquiry

Shanghai Terui OP New Material Technology Co., Ltd.

We have overseas warehouses in California, New Laredo Mexico, Vancouver Canada, Amsterdam Netherlands, and Melbourne Australia. Overseas warehouses can provide some of the best-selling products. We look forward to the cooperation of local powerful

Chinese suppliers CAS 656247-17-5 Nintedanib

Cas:656247-17-5

Min.Order:0 Metric Ton

Negotiable

Type:Trading Company

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Shandong Hanjiang Chemical Co., Ltd.

Hello, dear friend! I'm Hansen and Allen from China. Welcome to my lookchem mall! The following is a brief introduction of our company's products and services. If you are interested in our products, please contact us by emai

Nintedanib

Cas:656247-17-5

Min.Order:1 Kilogram

Negotiable

Type:Lab/Research institutions

inquiry

Hebei Mojin Biotechnology Co.,Ltd

Hebei Mojin Biotechnology Co., Ltd, Our company is a professional in lead acetate, diphenyl ethylamine and other chemical raw materials and chemical reagents research and development production enterprises. Our business covers more than 30 countries,

High quality of Nintedanib

Cas:656247-17-5

Min.Order:1 Kilogram

FOB Price: $25.0

Type:Trading Company

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Henan Wentao Chemical Product Co., Ltd.

Henan Wentao Chemical Product Co.,Ltd is Located in Zhengzhou High-tech Development Zone with import and export license, We passed ISO 9001:2008 as well, Henan Wentao has developed more than 1000 compounds, which are widely used in the fields of prod

Intedanib

Cas:656247-17-5

Min.Order:0

Negotiable

Type:Lab/Research institutions

inquiry

Triumph International Development Limilted

Appearance:white or light yellow crystalline powder Storage:Store in a cool,dry place and keep away from direct strong light Package:As customer request Application:Used for research and industrial manufacture. Transportation:By

Afine Chemicals Limited

1. "Top 100 innovation-oriented export enterprises Of Hangzhou" honored by Hangzhou government 2. Specialized in the fine chemicals and pharmaceuticals 3. A leading manufacturer and trader of

Supply Nintedanib high quality Hot sale 99.0% Nintedanib price market

Cas:656247-17-5

Min.Order:1 Kilogram

Negotiable

Type:Lab/Research institutions

inquiry

Hangzhou J&H Chemical Co., Ltd.

J&H CHEM R&D center can offer custom synthesis according to the contract research and development services for the fine chemicals, pharmaceutical, biotechnique and some of the other chemicals. J&H CHEM has some Manufacturing base in Jia

Vargatef

Cas:656247-17-5

Min.Order:1 Gram

Negotiable

Type:Lab/Research institutions

inquiry

Nanjing Fred Technology Co.,Ltd.

Nintedanib is one of the most competitive products in our company, we can supply it with good quality and best price. Appearance:Yellow to brown solid Storage:Room temperature, Keep in Dark Place. Package:According to the demand of customer Applicati

Nintedanib

Cas:656247-17-5

Min.Order:1 Kilogram

Negotiable

Type:Lab/Research institutions

inquiry

Taizhou Crene Biotechnology co.ltd

Our company provides one-stop services of research - development - production for a variety of special prouducts. Not only do we make effective use of our strong technological strength, but also establish of cooperative relations with several well-

BIBF1120 Nintedanib 656247-17-5

Cas:656247-17-5

Min.Order:5 Gram

Negotiable

Type:Lab/Research institutions

inquiry

Synthetic route

methyl (3Z)-3-[({4-[N-methyl-2-(4-methylpiperazin-1-yl)acetamido]phenyl}amino)(phenyl)methylidene]-2-oxo-2,3-dihydro-1H-indole-6-carboxylate ethanesulfonate salt
656247-18-6

methyl (3Z)-3-[({4-[N-methyl-2-(4-methylpiperazin-1-yl)acetamido]phenyl}amino)(phenyl)methylidene]-2-oxo-2,3-dihydro-1H-indole-6-carboxylate ethanesulfonate salt

nintedanib
656247-17-5

nintedanib

Conditions
ConditionsYield
With sodium hydrogencarbonate In water; ethyl acetate at 40℃; for 1h;98.7%
With sodium carbonate In water pH=9; Solvent; pH-value;20 g
N-[(4-methyl-piperazin-1-yl)methylcarbonyl]-N-methyl-p-phenylendiamine
262368-30-9

N-[(4-methyl-piperazin-1-yl)methylcarbonyl]-N-methyl-p-phenylendiamine

(E)-1-acetyl-3-(methoxy-phenyl-methylene)-2-oxo-2,3-dihydro-1H-indole-6-carboxylic acid methyl ester
1168152-07-5

(E)-1-acetyl-3-(methoxy-phenyl-methylene)-2-oxo-2,3-dihydro-1H-indole-6-carboxylic acid methyl ester

nintedanib
656247-17-5

nintedanib

Conditions
ConditionsYield
Stage #1: N-[(4-methyl-piperazin-1-yl)methylcarbonyl]-N-methyl-p-phenylendiamine; (E)-1-acetyl-3-(methoxy-phenyl-methylene)-2-oxo-2,3-dihydro-1H-indole-6-carboxylic acid methyl ester With methanol In N,N-dimethyl-formamide at 75℃; for 4h; Large scale;
Stage #2: With methanol; potassium hydroxide In N,N-dimethyl-formamide Temperature; Large scale;
94.6%
Stage #1: N-[(4-methyl-piperazin-1-yl)methylcarbonyl]-N-methyl-p-phenylendiamine; (E)-1-acetyl-3-(methoxy-phenyl-methylene)-2-oxo-2,3-dihydro-1H-indole-6-carboxylic acid methyl ester In methanol for 5h; Reflux;
Stage #2: With potassium hydroxide In methanol at 20 - 70℃; for 0.5h; Concentration; Reagent/catalyst; Temperature; Solvent;
90%
Stage #1: N-[(4-methyl-piperazin-1-yl)methylcarbonyl]-N-methyl-p-phenylendiamine; (E)-1-acetyl-3-(methoxy-phenyl-methylene)-2-oxo-2,3-dihydro-1H-indole-6-carboxylic acid methyl ester In methanol; N,N-dimethyl-formamide Reflux;
Stage #2: With piperidine In methanol; N,N-dimethyl-formamide Reflux;
88%
Stage #1: N-[(4-methyl-piperazin-1-yl)methylcarbonyl]-N-methyl-p-phenylendiamine; (E)-1-acetyl-3-(methoxy-phenyl-methylene)-2-oxo-2,3-dihydro-1H-indole-6-carboxylic acid methyl ester In methanol for 5h; Reflux;
Stage #2: With potassium hydroxide In methanol
84%
Stage #1: N-[(4-methyl-piperazin-1-yl)methylcarbonyl]-N-methyl-p-phenylendiamine; (E)-1-acetyl-3-(methoxy-phenyl-methylene)-2-oxo-2,3-dihydro-1H-indole-6-carboxylic acid methyl ester In N,N-dimethyl-formamide at 80℃; for 1h;
Stage #2: With piperidine In N,N-dimethyl-formamide at 20℃; for 2h;
77%
1-methyl-piperazine
109-01-3

1-methyl-piperazine

methyl 1-acetyl-3-(((4-(2-chloro-N-methylacetamido)phenyl)amino)(phenyl)methylene)-2-oxoindoline-6-carboxylate

methyl 1-acetyl-3-(((4-(2-chloro-N-methylacetamido)phenyl)amino)(phenyl)methylene)-2-oxoindoline-6-carboxylate

nintedanib
656247-17-5

nintedanib

Conditions
ConditionsYield
In N,N-dimethyl-formamide at 45 - 50℃;93.74%
1-methyl-piperazine
109-01-3

1-methyl-piperazine

methyl-1-acetyl-3-((4-(2-chloro-N-ethylacetamido)phenyl)amino(phenyl)methylene)-2-oxoindoline-6-carboxylate

methyl-1-acetyl-3-((4-(2-chloro-N-ethylacetamido)phenyl)amino(phenyl)methylene)-2-oxoindoline-6-carboxylate

nintedanib
656247-17-5

nintedanib

Conditions
ConditionsYield
In N,N-dimethyl-formamide at 45 - 50℃;93.74%
1-methyl-piperazine
109-01-3

1-methyl-piperazine

C26H22ClN3O4

C26H22ClN3O4

nintedanib
656247-17-5

nintedanib

Conditions
ConditionsYield
In toluene at 65℃; for 4h; Solvent; Temperature;93%
N-[(4-methyl-piperazin-1-yl)methylcarbonyl]-N-methyl-p-phenylendiamine
262368-30-9

N-[(4-methyl-piperazin-1-yl)methylcarbonyl]-N-methyl-p-phenylendiamine

methyl 3-[bromo(phenyl)methylidene]-2-oxoindoline-6-formate

methyl 3-[bromo(phenyl)methylidene]-2-oxoindoline-6-formate

nintedanib
656247-17-5

nintedanib

Conditions
ConditionsYield
With sodium hydrogencarbonate In ethanol for 2h; Reflux;92.7%
N-[(4-methyl-piperazin-1-yl)methylcarbonyl]-N-methyl-p-phenylendiamine
262368-30-9

N-[(4-methyl-piperazin-1-yl)methylcarbonyl]-N-methyl-p-phenylendiamine

methyl 1-acetyl-3-[methoxy(phenyl)methylidene]-2-oxo-2,3-dihydro-1H-indole-6-carboxylate

methyl 1-acetyl-3-[methoxy(phenyl)methylidene]-2-oxo-2,3-dihydro-1H-indole-6-carboxylate

nintedanib
656247-17-5

nintedanib

Conditions
ConditionsYield
With pyrrolidine In methanol at 25 - 50℃; for 6h;91.37%
1-acetyl-3-(Z)-[1-(4-(N-((4-methylpiperazin-1-yl)methylcarbonyl)-N-methylaminophenyl)amino)-1-phenylmethylene]-6-methoxycarbonyl-2-indolinone

1-acetyl-3-(Z)-[1-(4-(N-((4-methylpiperazin-1-yl)methylcarbonyl)-N-methylaminophenyl)amino)-1-phenylmethylene]-6-methoxycarbonyl-2-indolinone

nintedanib
656247-17-5

nintedanib

Conditions
ConditionsYield
With methanol; potassium hydroxide at 20℃; Reagent/catalyst; Large scale;91.3%
With methanol; potassium hydroxide at 50 - 55℃; for 2h; Temperature;
N-[(4-methyl-piperazin-1-yl)methylcarbonyl]-N-methyl-p-phenylendiamine
262368-30-9

N-[(4-methyl-piperazin-1-yl)methylcarbonyl]-N-methyl-p-phenylendiamine

(E)-methyl 3-(methoxy(phenyl)methylene)-2-indolone-6-carboxylic acid methyl ester
1168150-46-6

(E)-methyl 3-(methoxy(phenyl)methylene)-2-indolone-6-carboxylic acid methyl ester

nintedanib
656247-17-5

nintedanib

Conditions
ConditionsYield
In methanol for 8h; Reflux;90.8%
benzoic acid methyl ester
93-58-3

benzoic acid methyl ester

N-[(4-methyl-piperazin-1-yl)methylcarbonyl]-N-methyl-p-phenylendiamine
262368-30-9

N-[(4-methyl-piperazin-1-yl)methylcarbonyl]-N-methyl-p-phenylendiamine

2-oxo-2,3-dihydro-1H-indole-6-carboxylic acid methyl ester
14192-26-8

2-oxo-2,3-dihydro-1H-indole-6-carboxylic acid methyl ester

nintedanib
656247-17-5

nintedanib

Conditions
ConditionsYield
Stage #1: benzoic acid methyl ester; 2-oxo-2,3-dihydro-1H-indole-6-carboxylic acid methyl ester With potassium carbonate In N,N-dimethyl-formamide at 20℃; for 3h;
Stage #2: N-[(4-methyl-piperazin-1-yl)methylcarbonyl]-N-methyl-p-phenylendiamine In N,N-dimethyl-formamide at 20℃; for 4h;
89.7%
N-[(4-methyl-piperazin-1-yl)methylcarbonyl]-N-methyl-p-phenylendiamine
262368-30-9

N-[(4-methyl-piperazin-1-yl)methylcarbonyl]-N-methyl-p-phenylendiamine

3-[methoxy(phenyl)methylene]-2-oxoindoline-6-carboxylic acid methyl ester
1160293-22-0

3-[methoxy(phenyl)methylene]-2-oxoindoline-6-carboxylic acid methyl ester

nintedanib
656247-17-5

nintedanib

Conditions
ConditionsYield
In methanol at 10℃; for 9.5h; Product distribution / selectivity; Heating / reflux;89%
In methanol for 7.5h; Product distribution / selectivity; Heating / reflux;89%
In methanol; N,N-dimethyl-formamide at 0℃; for 9h; Product distribution / selectivity; Heating / reflux;88.1%
N-[(4-methyl-piperazin-1-yl)methylcarbonyl]-N-methyl-p-phenylendiamine
262368-30-9

N-[(4-methyl-piperazin-1-yl)methylcarbonyl]-N-methyl-p-phenylendiamine

methyl 1-acetyl-3-[ethoxy(phenyl)methylidene]-2-oxo-2,3-dihydro-7H-indole-6-carboxylate
1175365-43-1

methyl 1-acetyl-3-[ethoxy(phenyl)methylidene]-2-oxo-2,3-dihydro-7H-indole-6-carboxylate

nintedanib
656247-17-5

nintedanib

Conditions
ConditionsYield
Stage #1: N-[(4-methyl-piperazin-1-yl)methylcarbonyl]-N-methyl-p-phenylendiamine; methyl 1-acetyl-3-[ethoxy(phenyl)methylidene]-2-oxo-2,3-dihydro-7H-indole-6-carboxylate In DMF (N,N-dimethyl-formamide) at 80℃; for 1h;
Stage #2: With piperidine In DMF (N,N-dimethyl-formamide) at 20℃; for 2h;
77%
N-[(4-methyl-piperazin-1-yl)methylcarbonyl]-N-methyl-p-phenylendiamine
262368-30-9

N-[(4-methyl-piperazin-1-yl)methylcarbonyl]-N-methyl-p-phenylendiamine

(Z)-1-acetyl-3-(ethoxy-phenyl-methylene)-2-oxo-2,3-dihydro-1H-indole-6-carboxylic acid methyl ester
1027407-75-5

(Z)-1-acetyl-3-(ethoxy-phenyl-methylene)-2-oxo-2,3-dihydro-1H-indole-6-carboxylic acid methyl ester

nintedanib
656247-17-5

nintedanib

Conditions
ConditionsYield
With piperidine In DMF (N,N-dimethyl-formamide) at 20 - 80℃; for 3h;77%
Stage #1: N-[(4-methyl-piperazin-1-yl)methylcarbonyl]-N-methyl-p-phenylendiamine; (Z)-1-acetyl-3-(ethoxy-phenyl-methylene)-2-oxo-2,3-dihydro-1H-indole-6-carboxylic acid methyl ester In N,N-dimethyl-formamide at 80℃; for 1h;
Stage #2: With piperidine at 20℃; for 2h;
72%
Stage #1: N-[(4-methyl-piperazin-1-yl)methylcarbonyl]-N-methyl-p-phenylendiamine; (Z)-1-acetyl-3-(ethoxy-phenyl-methylene)-2-oxo-2,3-dihydro-1H-indole-6-carboxylic acid methyl ester In N,N-dimethyl-formamide at 180℃; for 8h;
Stage #2: With piperidine In N,N-dimethyl-formamide at 20℃; for 2h;
72%
Stage #1: N-[(4-methyl-piperazin-1-yl)methylcarbonyl]-N-methyl-p-phenylendiamine; (Z)-1-acetyl-3-(ethoxy-phenyl-methylene)-2-oxo-2,3-dihydro-1H-indole-6-carboxylic acid methyl ester In N,N-dimethyl-formamide at 80℃; for 1h;
Stage #2: With piperidine In N,N-dimethyl-formamide at 20℃; for 2h;
1.3 g
N-[(4-methyl-piperazin-1-yl)methylcarbonyl]-N-methyl-p-phenylendiamine
262368-30-9

N-[(4-methyl-piperazin-1-yl)methylcarbonyl]-N-methyl-p-phenylendiamine

methyl (Z)-3-(methoxy(phenyl)methylene)-2-oxoindole-6-carboxylate

methyl (Z)-3-(methoxy(phenyl)methylene)-2-oxoindole-6-carboxylate

nintedanib
656247-17-5

nintedanib

Conditions
ConditionsYield
With methanol In N,N-dimethyl-formamide for 5h; Reflux;73.2%
N-methyl(p-nitroaniline)
100-15-2

N-methyl(p-nitroaniline)

nintedanib
656247-17-5

nintedanib

Conditions
ConditionsYield
Multi-step reaction with 3 steps
1.1: dmap / dichloromethane / 5 - 20 °C
2.1: toluene / 2.5 h / 40 - 55 °C
2.2: 20 °C / 750.08 Torr
3.1: methanol / 8 h / Reflux
View Scheme
Multi-step reaction with 4 steps
1.1: lithium carbonate / 1,4-dioxane; water / 3 h / 33 °C
2.1: potassium carbonate / acetone / 12 h / 20 °C
3.1: palladium 10% on activated carbon; hydrogen / methanol / 2 h / 20 °C / 2585.81 Torr
4.1: N,N-dimethyl-formamide / 1 h / 80 °C
4.2: 2 h / 20 °C
View Scheme
Multi-step reaction with 6 steps
1.1: triethylamine / isopropyl alcohol / 0.25 h / 25 °C
1.2: 3 h / 25 °C
2.1: hydrogen; palladium on activated charcoal / isopropyl alcohol / 12 h / 30 °C
3.1: acetic acid / N,N-dimethyl-formamide / 0.25 h / 20 °C
3.2: 5 h / 90 °C
4.1: hydrogenchloride / methanol; dichloromethane / 3 h / 20 °C
5.1: ethyl acetate / 1 h / 40 °C / Inert atmosphere
6.1: toluene / 4 h / 65 °C
View Scheme
Multi-step reaction with 4 steps
1.1: ethyl acetate / 1 h / 70 °C
2.1: toluene / 2 h / 55 °C
3.1: palladium on activated charcoal; hydrogen / isopropyl alcohol / 12 h / 20 °C
4.1: N,N-dimethyl-formamide / 1 h / 80 °C
4.2: 2 h / 20 °C
View Scheme
Multi-step reaction with 4 steps
1.1: ethyl acetate / 1 h / 70 °C
2.1: toluene / 2 h / 55 °C
3.1: palladium on activated charcoal; hydrogen / isopropyl alcohol / 12 h / 20 °C
4.1: N,N-dimethyl-formamide / 8 h / 180 °C
4.2: 2 h / 20 °C
View Scheme
2-oxo-2,3-dihydro-1H-indole-6-carboxylic acid methyl ester
14192-26-8

2-oxo-2,3-dihydro-1H-indole-6-carboxylic acid methyl ester

nintedanib
656247-17-5

nintedanib

Conditions
ConditionsYield
Multi-step reaction with 4 steps
1.1: toluene / 4 h / Reflux
2.1: acetic anhydride / toluene / Reflux
2.2: 120 h / 20 - 104 °C
3.1: potassium hydroxide; methanol / 0.67 h / Reflux
4.1: methanol / 8 h / Reflux
View Scheme
Multi-step reaction with 2 steps
1.1: toluene / 110 °C
2.1: N,N-dimethyl-formamide / 1 h / 80 °C
2.2: 2 h / 20 °C
View Scheme
Multi-step reaction with 4 steps
1: toluene; cyclohexane / 6 h / 80 - 90 °C / Inert atmosphere
2: acetic anhydride / toluene / 4 h / Reflux
3: methanol; potassium hydroxide / 3 h / Reflux
4: methanol / N,N-dimethyl-formamide / 5 h / Reflux
View Scheme
methyl 1-(2-chloroacetyl)-2-oxoindoline-6-carboxylate
1160293-25-3

methyl 1-(2-chloroacetyl)-2-oxoindoline-6-carboxylate

nintedanib
656247-17-5

nintedanib

Conditions
ConditionsYield
Multi-step reaction with 3 steps
1.1: acetic anhydride / toluene / Reflux
1.2: 120 h / 20 - 104 °C
2.1: potassium hydroxide; methanol / 0.67 h / Reflux
3.1: methanol / 8 h / Reflux
View Scheme
Multi-step reaction with 3 steps
1: acetic anhydride / toluene / 4 h / Reflux
2: methanol; potassium hydroxide / 3 h / Reflux
3: methanol / N,N-dimethyl-formamide / 5 h / Reflux
View Scheme
Multi-step reaction with 6 steps
1.1: acetic anhydride / 6 h / 124 °C
2.1: sodium carbonate / methanol / 0.5 h / 63 °C
3.1: acetic acid / N,N-dimethyl-formamide / 0.25 h / 20 °C
3.2: 5 h / 90 °C
4.1: hydrogenchloride / methanol; dichloromethane / 3 h / 20 °C
5.1: ethyl acetate / 1 h / 40 °C / Inert atmosphere
6.1: toluene / 4 h / 65 °C
View Scheme
(E)-1-cholroacetyl-3-(methoxy(phenyl)methylene)-2-indolone-6-methylformate
1174335-83-1

(E)-1-cholroacetyl-3-(methoxy(phenyl)methylene)-2-indolone-6-methylformate

nintedanib
656247-17-5

nintedanib

Conditions
ConditionsYield
Multi-step reaction with 2 steps
1: potassium hydroxide; methanol / 0.67 h / Reflux
2: methanol / 8 h / Reflux
View Scheme
2-chloro-N-methyl-N-(4-nitrophenyl)acetamide
2653-16-9

2-chloro-N-methyl-N-(4-nitrophenyl)acetamide

nintedanib
656247-17-5

nintedanib

Conditions
ConditionsYield
Multi-step reaction with 3 steps
1.1: potassium carbonate / acetone / 12 h / 20 °C
2.1: palladium 10% on activated carbon; hydrogen / methanol / 2 h / 20 °C / 2585.81 Torr
3.1: N,N-dimethyl-formamide / 1 h / 80 °C
3.2: 2 h / 20 °C
View Scheme
Multi-step reaction with 3 steps
1.1: toluene / 2 h / 55 °C
2.1: palladium on activated charcoal; hydrogen / isopropyl alcohol / 12 h / 20 °C
3.1: N,N-dimethyl-formamide / 1 h / 80 °C
3.2: 2 h / 20 °C
View Scheme
Multi-step reaction with 3 steps
1: acetic acid; iron / water / 1.5 h / 20 - 45 °C
2: methanol; N,N-dimethyl-formamide / 12 h / 60 - 65 °C
3: N,N-dimethyl-formamide / 45 - 50 °C
View Scheme
Multi-step reaction with 3 steps
1.1: toluene / 2 h / 55 °C
2.1: palladium on activated charcoal; hydrogen / isopropyl alcohol / 12 h / 20 °C
3.1: N,N-dimethyl-formamide / 8 h / 180 °C
3.2: 2 h / 20 °C
View Scheme
Multi-step reaction with 3 steps
1: ethyl acetate / 2 h / 40 - 50 °C
2: palladium 10% on activated carbon; hydrogen / isopropyl alcohol / 20 °C
3: methanol; N,N-dimethyl-formamide / 7 h / Reflux
View Scheme
N-methyl-2-(4-methylpiperazin-1-yl)-N-(4-nitrophenyl)-acetamide
1139453-98-7

N-methyl-2-(4-methylpiperazin-1-yl)-N-(4-nitrophenyl)-acetamide

nintedanib
656247-17-5

nintedanib

Conditions
ConditionsYield
Multi-step reaction with 2 steps
1.1: palladium 10% on activated carbon; hydrogen / methanol / 2 h / 20 °C / 2585.81 Torr
2.1: N,N-dimethyl-formamide / 1 h / 80 °C
2.2: 2 h / 20 °C
View Scheme
Multi-step reaction with 2 steps
1.1: palladium on activated charcoal; hydrogen / isopropyl alcohol / 12 h / 20 °C
2.1: N,N-dimethyl-formamide / 1 h / 80 °C
2.2: 2 h / 20 °C
View Scheme
Multi-step reaction with 2 steps
1.1: palladium on activated charcoal; hydrogen / isopropyl alcohol / 12 h / 20 °C
2.1: N,N-dimethyl-formamide / 8 h / 180 °C
2.2: 2 h / 20 °C
View Scheme
Multi-step reaction with 2 steps
1: palladium 10% on activated carbon; hydrogen / isopropyl alcohol / 20 °C
2: methanol; N,N-dimethyl-formamide / 7 h / Reflux
View Scheme
4-methoxycarbonylmethyl-3-nitrobenzoic acid methyl ester
334952-07-7

4-methoxycarbonylmethyl-3-nitrobenzoic acid methyl ester

nintedanib
656247-17-5

nintedanib

Conditions
ConditionsYield
Multi-step reaction with 3 steps
1.1: acetic acid; palladium 10% on activated carbon; hydrogen / 2.5 h / 20 °C / 2585.81 Torr
2.1: toluene / 110 °C
3.1: N,N-dimethyl-formamide / 1 h / 80 °C
3.2: 2 h / 20 °C
View Scheme
Multi-step reaction with 4 steps
1: acetic anhydride / Reflux
2: N,N-dimethyl-formamide / 2 h / 80 - 85 °C
3: palladium 10% on activated carbon; isopropyl alcohol / 4 h / 20 °C / 3750.38 - 6000.6 Torr
4: toluene / 5 h / 115 - 120 °C
View Scheme
methyl 3-nitrobenzoate
618-95-1

methyl 3-nitrobenzoate

nintedanib
656247-17-5

nintedanib

Conditions
ConditionsYield
Multi-step reaction with 4 steps
1.1: potassium tert-butylate / N,N-dimethyl-formamide / 0.17 h / -10 °C
2.1: acetic acid; palladium 10% on activated carbon; hydrogen / 2.5 h / 20 °C / 2585.81 Torr
3.1: toluene / 110 °C
4.1: N,N-dimethyl-formamide / 1 h / 80 °C
4.2: 2 h / 20 °C
View Scheme
para-nitrophenyl bromide
586-78-7

para-nitrophenyl bromide

nintedanib
656247-17-5

nintedanib

Conditions
ConditionsYield
Multi-step reaction with 5 steps
1.1: 16 h / 20 °C / Heating; Sealed tube
2.1: lithium carbonate / 1,4-dioxane; water / 3 h / 33 °C
3.1: potassium carbonate / acetone / 12 h / 20 °C
4.1: palladium 10% on activated carbon; hydrogen / methanol / 2 h / 20 °C / 2585.81 Torr
5.1: N,N-dimethyl-formamide / 1 h / 80 °C
5.2: 2 h / 20 °C
View Scheme
3-nitrobenzoic acid
121-92-6

3-nitrobenzoic acid

nintedanib
656247-17-5

nintedanib

Conditions
ConditionsYield
Multi-step reaction with 5 steps
1.1: thionyl chloride / 2 h / 0 - 50 °C
2.1: potassium tert-butylate / N,N-dimethyl-formamide / 0.17 h / -10 °C
3.1: acetic acid; palladium 10% on activated carbon; hydrogen / 2.5 h / 20 °C / 2585.81 Torr
4.1: toluene / 110 °C
5.1: N,N-dimethyl-formamide / 1 h / 80 °C
5.2: 2 h / 20 °C
View Scheme
methyl-1-(chloroacetyl)-3-[methoxy(phenyl)methylene]-2-oxoindoline-6-carboxylate

methyl-1-(chloroacetyl)-3-[methoxy(phenyl)methylene]-2-oxoindoline-6-carboxylate

nintedanib
656247-17-5

nintedanib

Conditions
ConditionsYield
Multi-step reaction with 2 steps
1: methanol; potassium hydroxide / 3 h / Reflux
2: methanol / N,N-dimethyl-formamide / 5 h / Reflux
View Scheme
N-chloroacetyl-3-[methoxy(phenyl)methylene]-2-oxoindoline-6-carboxylic acid methyl ester
1160293-24-2

N-chloroacetyl-3-[methoxy(phenyl)methylene]-2-oxoindoline-6-carboxylic acid methyl ester

nintedanib
656247-17-5

nintedanib

Conditions
ConditionsYield
Multi-step reaction with 5 steps
1.1: sodium carbonate / methanol / 0.5 h / 63 °C
2.1: acetic acid / N,N-dimethyl-formamide / 0.25 h / 20 °C
2.2: 5 h / 90 °C
3.1: hydrogenchloride / methanol; dichloromethane / 3 h / 20 °C
4.1: ethyl acetate / 1 h / 40 °C / Inert atmosphere
5.1: toluene / 4 h / 65 °C
View Scheme
3-[methoxy(phenyl)methylene]-2-oxoindoline-6-carboxylic acid methyl ester
1160293-22-0

3-[methoxy(phenyl)methylene]-2-oxoindoline-6-carboxylic acid methyl ester

nintedanib
656247-17-5

nintedanib

Conditions
ConditionsYield
Multi-step reaction with 4 steps
1.1: acetic acid / N,N-dimethyl-formamide / 0.25 h / 20 °C
1.2: 5 h / 90 °C
2.1: hydrogenchloride / methanol; dichloromethane / 3 h / 20 °C
3.1: ethyl acetate / 1 h / 40 °C / Inert atmosphere
4.1: toluene / 4 h / 65 °C
View Scheme
methyl 3-nitro-4-chlorobenzoate
14719-83-6

methyl 3-nitro-4-chlorobenzoate

nintedanib
656247-17-5

nintedanib

Conditions
ConditionsYield
Multi-step reaction with 10 steps
1.1: sodium tert-pentoxide / 1-methyl-pyrrolidin-2-one / 1.5 h / 75 °C
2.1: palladium 10% on activated carbon; hydrogen / acetic acid / 45 °C
3.1: acetic acid / 2 h / 115 °C
4.1: toluene / 3 h / 120 °C
5.1: acetic anhydride / 6 h / 124 °C
6.1: sodium carbonate / methanol / 0.5 h / 63 °C
7.1: acetic acid / N,N-dimethyl-formamide / 0.25 h / 20 °C
7.2: 5 h / 90 °C
8.1: hydrogenchloride / methanol; dichloromethane / 3 h / 20 °C
9.1: ethyl acetate / 1 h / 40 °C / Inert atmosphere
10.1: toluene / 4 h / 65 °C
View Scheme
[4-(methoxycarbonyl)-2-nitrophenyl]malonic acid dimethyl ester
1160293-27-5

[4-(methoxycarbonyl)-2-nitrophenyl]malonic acid dimethyl ester

nintedanib
656247-17-5

nintedanib

Conditions
ConditionsYield
Multi-step reaction with 9 steps
1.1: palladium 10% on activated carbon; hydrogen / acetic acid / 45 °C
2.1: acetic acid / 2 h / 115 °C
3.1: toluene / 3 h / 120 °C
4.1: acetic anhydride / 6 h / 124 °C
5.1: sodium carbonate / methanol / 0.5 h / 63 °C
6.1: acetic acid / N,N-dimethyl-formamide / 0.25 h / 20 °C
6.2: 5 h / 90 °C
7.1: hydrogenchloride / methanol; dichloromethane / 3 h / 20 °C
8.1: ethyl acetate / 1 h / 40 °C / Inert atmosphere
9.1: toluene / 4 h / 65 °C
View Scheme
nintedanib
656247-17-5

nintedanib

ethanesulfonic acid
594-45-6

ethanesulfonic acid

methyl (3Z)-3-[({4-[N-methyl-2-(4-methylpiperazin-1-yl)acetamido]phenyl}amino)(phenyl)methylidene]-2-oxo-2,3-dihydro-1H-indole-6-carboxylate ethanesulfonate salt
656247-18-6

methyl (3Z)-3-[({4-[N-methyl-2-(4-methylpiperazin-1-yl)acetamido]phenyl}amino)(phenyl)methylidene]-2-oxo-2,3-dihydro-1H-indole-6-carboxylate ethanesulfonate salt

Conditions
ConditionsYield
In methanol for 4h; Reflux;100%
In methanol; water at 60℃;97.3%
In methanol; water; isopropyl alcohol at 0 - 65℃; for 1h;95%
nintedanib
656247-17-5

nintedanib

L-Tartaric acid
87-69-4

L-Tartaric acid

methyl (3Z)-3-{[(4-{methyl[(4-methylpiperazin-1-yl)acetyl]amino}phenyl)amino](phenyl)methylidene}-2-oxo-2,3-dihydro-1H-indole-6-carboxylate L-tartrate

methyl (3Z)-3-{[(4-{methyl[(4-methylpiperazin-1-yl)acetyl]amino}phenyl)amino](phenyl)methylidene}-2-oxo-2,3-dihydro-1H-indole-6-carboxylate L-tartrate

Conditions
ConditionsYield
In water; butanone at 50℃; for 1.01667h;98%
nintedanib
656247-17-5

nintedanib

maleic acid
110-16-7

maleic acid

methyl (3Z)-3-{[(4-{methyl[(4-methylpiperazin-1-yl)acetyl]amino}phenyl)amino](phenyl)methylidene}-2-oxo-2,3-dihydro-1H-indole-6-carboxylate maleic acid salt
959761-95-6

methyl (3Z)-3-{[(4-{methyl[(4-methylpiperazin-1-yl)acetyl]amino}phenyl)amino](phenyl)methylidene}-2-oxo-2,3-dihydro-1H-indole-6-carboxylate maleic acid salt

Conditions
ConditionsYield
In water; ethyl acetate at 50℃; for 1.01667h;96%
nintedanib
656247-17-5

nintedanib

methanesulfonic acid
75-75-2

methanesulfonic acid

methyl (3Z)-3-{[(4-{methyl[(4-methylpiperazin-1-yl)acetyl]amino}phenyl)amino](phenyl)methylidene}-2-oxo-2,3-dihydro-1H-indole-6-carboxylate dimethanesulfonic acid salt

methyl (3Z)-3-{[(4-{methyl[(4-methylpiperazin-1-yl)acetyl]amino}phenyl)amino](phenyl)methylidene}-2-oxo-2,3-dihydro-1H-indole-6-carboxylate dimethanesulfonic acid salt

Conditions
ConditionsYield
In methanol at 50℃; for 1.01667h;93%
nintedanib
656247-17-5

nintedanib

methanesulfonic acid
75-75-2

methanesulfonic acid

methyl (3Z)-3-{[(4-{methyl[(4-methylpiperazin-1-yl)acetyl]amino}phenyl)amino](phenyl)methylidene}-2-oxo-2,3-dihydro-1H-indole-6-carboxylate methanesulfonic acid salt
790241-30-4

methyl (3Z)-3-{[(4-{methyl[(4-methylpiperazin-1-yl)acetyl]amino}phenyl)amino](phenyl)methylidene}-2-oxo-2,3-dihydro-1H-indole-6-carboxylate methanesulfonic acid salt

Conditions
ConditionsYield
In methanol; water at 60℃; for 1h;92%
nintedanib
656247-17-5

nintedanib

sodium dodecyl-sulfate
151-21-3

sodium dodecyl-sulfate

nintedanib dilauryl sulfate

nintedanib dilauryl sulfate

Conditions
ConditionsYield
With hydrogenchloride In methanol; water at 25 - 55℃; for 1.5h; Solvent;89.3%
nintedanib
656247-17-5

nintedanib

toluene-4-sulfonic acid
104-15-4

toluene-4-sulfonic acid

methyl (3Z)-3-{[(4-{methyl[(4-methylpiperazin-1-yl)acetyl]amino}phenyl)amino](phenyl)methylidene}-2-oxo-2,3-dihydro-1H-indole-6-carboxylate p-toluenesulfonic acid salt
959761-81-0

methyl (3Z)-3-{[(4-{methyl[(4-methylpiperazin-1-yl)acetyl]amino}phenyl)amino](phenyl)methylidene}-2-oxo-2,3-dihydro-1H-indole-6-carboxylate p-toluenesulfonic acid salt

Conditions
ConditionsYield
In water; butanone at 50℃; for 1.01667h; Solvent;86%
nintedanib
656247-17-5

nintedanib

sodium dodecyl-sulfate
151-21-3

sodium dodecyl-sulfate

nintedanib monolauryl sulfate

nintedanib monolauryl sulfate

Conditions
ConditionsYield
With hydrogenchloride; sodium hydrogencarbonate In ethanol; water at 60℃; for 1h; Solvent;81.5%
nintedanib
656247-17-5

nintedanib

methyl (3Z)-3-{[(4-{methyl[(4-methylpiperazin-1-yl)acetyl]amino}phenyl)amino](phenyl)methylidene}-2-oxo-2,3-dihydro-1H-indole-6-carboxylate phosphoric acid salt
959761-75-2

methyl (3Z)-3-{[(4-{methyl[(4-methylpiperazin-1-yl)acetyl]amino}phenyl)amino](phenyl)methylidene}-2-oxo-2,3-dihydro-1H-indole-6-carboxylate phosphoric acid salt

Conditions
ConditionsYield
With phosphoric acid In ethyl acetate at 50℃; for 0.0166667h;70%
nintedanib
656247-17-5

nintedanib

acetic acid
64-19-7

acetic acid

methyl (3Z)-3-{[(4-{methyl[(4-methylpiperazin-1-yl)acetyl]amino}phenyl)amino](phenyl)methylidene}-2-oxo-2,3-dihydro-1H-indole-6-carboxylate acetic acid salt

methyl (3Z)-3-{[(4-{methyl[(4-methylpiperazin-1-yl)acetyl]amino}phenyl)amino](phenyl)methylidene}-2-oxo-2,3-dihydro-1H-indole-6-carboxylate acetic acid salt

Conditions
ConditionsYield
In butanone at 50℃;64%
nintedanib
656247-17-5

nintedanib

nintedanib hydrochloride
959761-73-0

nintedanib hydrochloride

Conditions
ConditionsYield
With hydrogenchloride In tetrahydrofuran; 2,2,2-trifluoroethanol; water at 20 - 50℃; under 7.50075 Torr; for 48.5h;
With hydrogenchloride In water; acetone at 20 - 40℃; for 72h;
nintedanib
656247-17-5

nintedanib

ethanesulfonic acid
594-45-6

ethanesulfonic acid

Intedanib bisethanesulfonate

Intedanib bisethanesulfonate

Conditions
ConditionsYield
In methanol; water Reflux;

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