1000047-42-6

Basic information

• Product Name: N-{(S)-2-[2,2-dimethyl-4-(2-methylphenyl)-5-oxopiperazin-1-yl]-1-[(2S,4S)-4-isopropyl-5-oxotetrahydrofuran-2-yl]ethyl}-2-nitrobenzenesulfonamide
• Synonyms: N-{(S)-2-[2,2-dimethyl-4-(2-methylphenyl)-5-oxopiperazin-1-yl]-1-[(2S,4S)-4-isopropyl-5-oxotetrahydrofuran-2-yl]ethyl}-2-nitrobenzenesulfonamide
• CAS NO: 1000047-42-6
• Molecular Weight: 572.682
• Mol File: 1000047-42-6.mol
• Article Data: 2

Chemical Properties

• CAS DataBase Reference: N-{(S)-2-[2,2-dimethyl-4-(2-methylphenyl)-5-oxopiperazin-1-yl]-1-[(2S,4S)-4-isopropyl-5-oxotetrahydrofuran-2-yl]ethyl}-2-nitrobenzenesulfonamide(CAS DataBase Reference)
• NIST Chemistry Reference: N-{(S)-2-[2,2-dimethyl-4-(2-methylphenyl)-5-oxopiperazin-1-yl]-1-[(2S,4S)-4-isopropyl-5-oxotetrahydrofuran-2-yl]ethyl}-2-nitrobenzenesulfonamide(1000047-42-6)
• EPA Substance Registry System: N-{(S)-2-[2,2-dimethyl-4-(2-methylphenyl)-5-oxopiperazin-1-yl]-1-[(2S,4S)-4-isopropyl-5-oxotetrahydrofuran-2-yl]ethyl}-2-nitrobenzenesulfonamide(1000047-42-6)

Safety Data

• Hazardous Substances Data: 1000047-42-6(Hazardous Substances Data)

Upstream product

• 95-53-4 o-toluidine 
• 1000048-82-7 {2-[(2-bromoacetyl)-(2-methylphenyl)amino]-1,1-dimethylethyl}carbamic acid t-butyl ester 
• 1000048-77-0 [1,1-dimethyl-2-(2-methylphenylamino)ethyl]carbamic acid t-butyl ester 
• 1000047-41-5 5,5-dimethyl-1-(2-methylphenyl)piperazin-2-one 
• 1000045-31-7 (3S,5S)-3-isopropyl-5-[(2S)-1-(2-nitrobenzenesulfonyl)aziridine-2-yl]dihydrofuran-2-one 

Downstream Products

• 1000047-43-7 (2S,4S,5S)-6-[2,2-dimethyl-4-(2-methylphenyl)-5-oxopiperazin-1-yl]-4-hydroxy-2-isopropyl-5-(2-nitrobenzenesulfonylamino)hexanoic acid (2-carbamoyl-2-methylpropyl)amide 

Relevant articles and documents

Design and optimization of novel (2S,4S,5S)-5-amino-6-(2,2-dimethyl-5-oxo- 4-phenylpiperazin-1-yl)-4-hydroxy-2-isopropylhexanamides as renin inhibitors

Introduction of the 2,2-dimethyl-4-phenylpiperazin-5-one scaffold into the P3-P1 portion of the (2S,4S,5S)-5-amino-6-dialkylamino-4- hydroxy-2-isopropylhexanamide backbone dramatically increased the renin inhibitory activity without