1001409-50-2 Usage
General Description
PDK1 inhibitor is a type of chemical compound that specifically targets and inhibits the enzyme 3-phosphoinositide-dependent protein kinase-1 (PDK1). This enzyme is a key regulator of various cellular processes such as cell growth, survival, and metabolism, making it an attractive target for drug development in the treatment of cancer, diabetes, and other diseases. By blocking the activity of PDK1, PDK1 inhibitors have the potential to disrupt cancer cell proliferation, enhance insulin sensitivity, and modulate other signaling pathways involved in disease progression. Research into PDK1 inhibitors is ongoing, and these compounds show promise as potential therapeutic agents for a range of medical conditions.
Check Digit Verification of cas no
The CAS Registry Mumber 1001409-50-2 includes 10 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 7 digits, 1,0,0,1,4,0 and 9 respectively; the second part has 2 digits, 5 and 0 respectively.
Calculate Digit Verification of CAS Registry Number 1001409-50:
(9*1)+(8*0)+(7*0)+(6*1)+(5*4)+(4*0)+(3*9)+(2*5)+(1*0)=72
72 % 10 = 2
So 1001409-50-2 is a valid CAS Registry Number.
1001409-50-2Relevant articles and documents
Discovery of a potent and highly selective PDK1 inhibitor via fragment-based drug discovery
Erlanson, Daniel A.,Arndt, Joseph W.,Cancilla, Mark T.,Cao, Kathy,Elling, Robert A.,English, Nicki,Friedman, Jessica,Hansen, Stig K.,Hession, Cathy,Joseph, Ingrid,Kumaravel, Gnanasambandam,Lee, Wen-Cherng,Lind, Ken E.,McDowell, Robert S.,Miatkowski, Konrad,Nguyen, Christine,Nguyen, Thinh B.,Park, Sophia,Pathan, Nuzhat,Penny, David M.,Romanowski, Michael J.,Scott, Daniel,Silvian, Laura,Simmons, Robert L.,Tangonan, Bradley T.,Yang, Wenjin,Sun, Lihong
, p. 3078 - 3083 (2011/06/26)
We report the use of a fragment-based lead discovery method, Tethering with extenders, to discover a pyridinone fragment that binds in an adaptive site of the protein PDK1. With subsequent medicinal chemistry, this led to the discovery of a potent and hig
