1002-79-5Relevant articles and documents
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Abbot et al.
, p. 351,354, 361, 362 (1970)
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Transformation of Methyl Linoleate to its Conjugated Derivatives with Simple Pd(OAc)2/Lewis Acid Catalyst
Senan, Ahmed M.,Zhang, Sicheng,Qin, Shuhao,Chen, Zhuqi,Yin, Guochuan
, p. 1481 - 1489 (2017)
With the rapid depletion of fossil resources, the exploitation of biomass to partly replace fossil resources as the source of carbon in the chemical industry constitutes a promising alternative for the near future. This work introduces catalytic transformation of vegetable oil, i.e., methyl linoleate, to its conjugated esters by a simple Pd(OAc)2/Sc(OTf)3 catalyst, which has extensive applications in industry. It was found that adding non-redox metal ions like Sc(III) to a simple Pd(OAc)2 catalyst can effectively improve its isomerization activity in toluene/t-BuOH solvent, whereas Pd(OAc)2 alone is inactive. Preliminary mechanistic investigations together with previous studies suggested that the in situ-generated heterobimetallic Pd(II)/Sc(III) dimer serves as the key species for methyl linoleate isomerization, and the reaction proceeds by [1,3]-hydrogen shift mechanism involving a formal Pd(II)/Pd(IV) cycle.
Absorption Kinetics of the Main Conjugated Linoleic Acid Isomers in Commercial-Rich Oil after Oral Administration in Rats
Rodríguez-Alcalá, Luís M.,Ares, Irma,Fontecha, Javier,Martínez-Larra?aga, María-Rosa,Anadón, Arturo,Martínez, María-Aránzazu
, p. 7680 - 7686 (2017)
This study aimed to assess the oral absorption and plasma kinetics of two main isomers contained in commercial conjugated linoleic acid (CLA)-rich oil (Tonalin TG-80), rumenic acid (RA), and C18:2 trans-10, cis-12. The isomer plasma disposition after the single oral dose of 3000 mg of Tonalin TG-80/kg, containing 1200 mg/kg of each isomer, was studied in rats. The isomer plasma concentrations were determined by gas chromatography with flame ionization detection. The plasma kinetics showed rapid oral absorption of RA and C18:2 trans-10, cis-12 (t1/2a 0.34 ± 0.09 and 0.53 ± 0.01 h) and slow elimination (t1/2β 25.68 ± 3.29 and 18.12 ± 1.71 h); the maximal isomer plasma concentrations (Cmax) of 8.48 ± 0.98 and 7.67 ± 0.80 μg mL-1, respectively, were estimated at 2.08 ± 0.14 and 2.26 ± 0.11 h. Our results from a preclinical kinetic study in rats help to design future studies in humans for evaluating the CLA isomer dose-response.
Chemoenzymatic synthesis of conjugated linoleic acid
Chen, Chien-An,Sih, Charles J.
, p. 9620 - 9621 (1998)
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Hirabayashi et al.
, p. 2733 (1971)
