10035-17-3

Basic information

• Product Name: 2-bromo-1-(4-hydroxy-3-methoxy-phenyl)-propan-1-one
• Synonyms: 2-bromo-1-(4-hydroxy-3-methoxy-phenyl)-propan-1-one
• CAS NO: 10035-17-3
• Molecular Weight: 259.1
• Mol File: 10035-17-3.mol
• Article Data: 3

Chemical Properties

• CAS DataBase Reference: 2-bromo-1-(4-hydroxy-3-methoxy-phenyl)-propan-1-one(CAS DataBase Reference)
• NIST Chemistry Reference: 2-bromo-1-(4-hydroxy-3-methoxy-phenyl)-propan-1-one(10035-17-3)
• EPA Substance Registry System: 2-bromo-1-(4-hydroxy-3-methoxy-phenyl)-propan-1-one(10035-17-3)

Safety Data

• Hazardous Substances Data: 10035-17-3(Hazardous Substances Data)

Upstream product

• 90-05-1 2-methoxy-phenol 
• 7148-74-5 2-Bromopropionyl chloride 
• 1010800-80-2 4-(t-Butyldimethylsilyloxy)-3-methoxypropiophenone 
• 210555-50-3 C₁₆H₂₈O₃Si 
• 69404-94-0 O-tert-butyldimethylsilylvanillin 
• 91-16-7 1,2-dimethoxybenzene 
• 563-76-8 α-bromopropionyl bromide 

Downstream Products

• 121-34-6 3-methoxy-4-hydroxybenzoic acid 
• 121-33-5 vanillin 

Relevant articles and documents

Identification of a Novel TRPM8 Agonist from Nutmeg: A Promising Cooling Compound

The transient receptor potential melastatin 8 (TRPM8) ion channel is the primary receptor for innocuous cold stimuli (8′-7-ethoxy-4-hydroxy-3,3′,5′-trimethoxy-8-O-4′-neolignan (1) with an EC50 of 0.332 μM, which was isolated from a well-known spice, nutmeg (Myristica fragrans Houtt.). Structure activity relationships are also disclosed, showing that the 7-d-menthoxy derivative is the most potent agonist (EC50 = 11 nM). The combination of 1 and l-(-)-menthol has an additive effect, suggesting that neolignan compounds interact with TRPM8 at different sites from those of l-(-)-menthol.

Cooling Agent and TRPM8 Activator

Provided are a cooling agent having an excellent TRPM8 activating action, a TRPM8 activator, a method for imparting cooling sensation, and a novel compound useful for imparting cooling sensation. Disclosed is a cooling agent comprising, as an active ingre