1004316-93-1

Basic information

• Product Name: 3-methyl-1-[(3S)-2-oxooxolan-3-yl]-3-{[2-(propan-2-yl)-1,3-thiazol-4-yl]methyl}urea
• Synonyms: 3-methyl-1-[(3S)-2-oxooxolan-3-yl]-3-{[2-(propan-2-yl)-1,3-thiazol-4-yl]methyl}urea
• CAS NO: 1004316-93-1
• Molecular Formula: C₁₃H₁₉N₃O₃S
• Molecular Weight: 297.37326
• Mol File: 1004316-93-1.mol
• Article Data: 7

Chemical Properties

• Boiling Point: 564.2±50.0 °C(Predicted)
• Appearance: /
• Density: 1.27±0.1 g/cm3(Predicted)
• PKA: 12.30±0.20(Predicted)
• CAS DataBase Reference: 3-methyl-1-[(3S)-2-oxooxolan-3-yl]-3-{[2-(propan-2-yl)-1,3-thiazol-4-yl]methyl}urea(CAS DataBase Reference)
• NIST Chemistry Reference: 3-methyl-1-[(3S)-2-oxooxolan-3-yl]-3-{[2-(propan-2-yl)-1,3-thiazol-4-yl]methyl}urea(1004316-93-1)
• EPA Substance Registry System: 3-methyl-1-[(3S)-2-oxooxolan-3-yl]-3-{[2-(propan-2-yl)-1,3-thiazol-4-yl]methyl}urea(1004316-93-1)

Safety Data

• Hazardous Substances Data: 1004316-93-1(Hazardous Substances Data)

Upstream product

• 6305-38-0 (S)-(-)-α-amino-γ-butyrolactone hydrobromide 
• 154212-60-9 N-methyl-N-<(2-isopropyl-4-thiazolyl)methyl>amine 
• 530-62-1 1,1'-carbonyldiimidazole 
• 2185-02-6 L-homoserine lactone 
• 32315-10-9 bis(trichloromethyl) carbonate 

Downstream Products

• 1004316-87-3 C₃₆H₄₇N₇O₄S₂ 
• 1004316-92-0 C₁₇H₂₈N₄O₄S 
• 1004316-95-3 C₂₀H₂₅N₃O₄S 
• 1004316-96-4 C₂₄H₃₄N₄O₄S 
• 1169870-16-9 C₁₇H₂₇N₄O₄S^(1-)*K⁽¹⁺⁾ 
• 1247119-36-3 (S)-ethyl-2-(3-((2-isopropylthiazol-4-yl)methyl)-3-methylureido)-4-morpholinobutanoate oxalate 
• 1004316-94-2 C₂₀H₂₇N₃O₄S 
• 1169870-18-1 C₃₉H₅₁N₇O₅S₂ 
• 1169870-28-3 C₃₆H₅₃N₇O₅S₂ 

Relevant articles and documents

NOVEL PROCESS FOR THE PREPARATION OF 1,3-THIAZOL-5-YLMETHYL [(2R,5R)-5- CARBAMOYL) AMINO] -4-(MORPHOLIN-4-YL)BUTANOYL]AMINO}-1,6-DIPHENYLHEXAN-2-YL]CARBAMATE

The present invention relates to novel processes for the preparation 1,3-Thiazol-5-ylmethyl[(2R,5R)-5-{[(2S)-2-[(methyl{[2-(propan-2-yl)-1,3-thiazol-4-yl]methyl} carbamoyl)amino]-4-(morpholin-4-yl)butanoyl]amino}-1,6-diphenylhexan-2-yl] carbamate having the following structural formula-1 and it's intermediates thereof.

PREPARATION OF COBICISTAT INTERMEDIATES

The present disclosure provides crystalline piperidine sulfamoyl intermediates of formula 8 and 9. The present disclosure also relates to an improved process for the preparation of cobicistat using compounds of formulae 8 and 9.

PROCESS FOR THE PREPARATION OF COBICISTAT INTERMEDIATES

The present invention relates to cobicistat intermediates, processes and further conversion to cobicistat with improved yield and quality.