1004433-16-2

Basic information

• Product Name: 2-((4-nitrophenoxy)methyl)benzonitrile
• Synonyms: 2-((4-nitrophenoxy)methyl)benzonitrile
• CAS NO: 1004433-16-2
• Molecular Weight: 254.245
• Mol File: 1004433-16-2.mol
• Article Data: 2

Chemical Properties

• CAS DataBase Reference: 2-((4-nitrophenoxy)methyl)benzonitrile(CAS DataBase Reference)
• NIST Chemistry Reference: 2-((4-nitrophenoxy)methyl)benzonitrile(1004433-16-2)
• EPA Substance Registry System: 2-((4-nitrophenoxy)methyl)benzonitrile(1004433-16-2)

Safety Data

• Hazardous Substances Data: 1004433-16-2(Hazardous Substances Data)

Upstream product

• 100-02-7 4-nitro-phenol 
• 22115-41-9 2-(bromomethyl)benzonitrile 
• 612-13-5 2-cyanobenzyl chloride 

Relevant articles and documents

Structural optimization and structure–activity relationship of 4-thiazolidinone derivatives as novel inhibitors of human dihydroorotate dehydrogenase

Human dihydroorotate dehydrogenase (hDHODH), one of the attractive targets for the development of immunosuppressive drugs, is also a potential target of anticancer drugs and anti-leukemic drugs. The development of promising hDHODH inhibitors is in high demand. Based on the unique binding mode of our previous reported 4-thiazolidinone derivatives, via molecular docking method, three new series 4-thiazolidinone derivatives were designed and synthesized as hDHODH inhibitors. The preliminary structure–activity relationship was investigated. Compound 9 of biphenyl series and compound 37 of amide series displayed IC50 values of 1.32 μM and 1.45 μM, respectively. This research will provide valuable reference for the research of new structures of hDHODH inhibitors.