1006-40-2

Basic information

• Product Name: 2-bromo-4-fluorobenzamide
• Synonyms: 2-bromo-4-fluorobenzamide
• CAS NO: 1006-40-2
• Molecular Formula: C₇H₅BrFNO
• Molecular Weight: 218.0231032
• Mol File: 1006-40-2.mol
• Article Data: 4

Chemical Properties

• Appearance: /Solid
• CAS DataBase Reference: 2-bromo-4-fluorobenzamide(CAS DataBase Reference)
• NIST Chemistry Reference: 2-bromo-4-fluorobenzamide(1006-40-2)
• EPA Substance Registry System: 2-bromo-4-fluorobenzamide(1006-40-2)

Safety Data

• Hazardous Substances Data: 1006-40-2(Hazardous Substances Data)

Usage

General Description

2-bromo-4-fluorobenzamide is a chemical compound with the molecular formula C7H5BrFNO. It is a derivative of benzamide, which is commonly used as a building block in organic synthesis. The presence of a bromine atom and a fluorine atom in the benzene ring makes this compound a halogenated benzamide. 2-bromo-4-fluorobenzamide has been studied for its potential use in medicinal chemistry and as a molecular probe in biological research. It may have applications in the development of pharmaceutical drugs or as a tool for studying biological processes. Additionally, it could be used as a starting material for synthesizing other chemical compounds with specific properties or functions.

Upstream product

• 1006-41-3 2-bromo-4-fluorobenzoic acid 
• 824-75-9 p-fluorobenzamide 

Downstream Products

• 36282-26-5 2-bromo-4-fluorobenzonitrile 
• 1264526-27-3 7-fluoro-1-phenyl-2-thioxo-2,3-dihydroquinazolin-4(1H)-one 
• 1264526-42-2 1-(4-chlorophenyl)-7-fluoro-2-thioxo-2,3-dihydroquinazolin-4(1H)-one 
• 1264526-38-6 7-fluoro-1-(4-methoxyphenyl)-2-thioxo-2,3-dihydroquinazolin-4(1H)-one 
• 1264526-30-8 7-fluoro-2-thioxo-1-p-tolyl-2,3-dihydroquinazolin-4(1H)-one 
• 1264526-34-2 7-fluoro-2-thioxo-1-o-tolyl-2,3-dihydroquinazolin-4(1H)-one 
• 289038-14-8 2-bromo-4-fluorobenzylamine hydrochloride 
• 1293323-83-7 (2-bromo-4-fluorobenzyl)(cyclohex-2-enyl)carbamic acid tert-butyl ester 
• 159803-11-9 6-fluorobenzo[d]isothiazol-3(2H)-one 

Relevant articles and documents

Nickel-catalyzed regioselective C-H halogenation of electron-deficient arenes

A straightforward Ni(ii)-catalyzed general strategy was developed for the ortho-halogenation of electron-deficient arenes with easily available halogenating reagents N-halosuccinimides (NXS; X = Br, Cl and I). The transformation was highly regioselective and a wide substrate scope and functional group tolerance were observed. This discovery could be of great significance for the selective halogenation of amides, benzoic esters and other substances with guiding groups. Mechanistic investigations were also described.

Acid-promoted palladium(II)-catalyzed ortho-halogenation of primary benzamides: En route to halo-arenes

Br?nsted acid-promoted palladium(II)-catalyzed regioselective installation of halogens (Br, Cl, and I) to the aromatic ring of benzamide derivatives has been achieved using primary amides. A wide variety of benzamides were compatible under established conditions to afford the halogenated products without installing any external auxiliary. Mild reaction conditions, use of primary amide as a directing group, external additive-free conditions, and gram-scale reaction are some appealing features of this protocol. Detailed experimental results revealed that Br?nsted acid plays a critical role in this transformation.