100644-67-5

Basic information

• Product Name: 4-METHOXY-1H-PYRAZOLO[3,4-D]PYRIMIDIN-6-AMINE
• Synonyms: 6-Amino-4-methoxypyrazolo[3,4-d]pyrimidine;4-METHOXY-1H-PYRAZOLO[3,4-D]PYRIMIDIN-6-AMINE;6-AMINO-4-METHOXY-1H-PYRAZOLO[3,4-D]PYRIMIDINE
• CAS NO: 100644-67-5
• Molecular Formula: C₆H₇N₅O
• Molecular Weight: 165.15
• Mol File: 100644-67-5.mol
• Article Data: 4

Chemical Properties

• Appearance: /
• Storage Temp.: Keep in dark place,Inert atmosphere,Room temperature
• CAS DataBase Reference: 4-METHOXY-1H-PYRAZOLO[3,4-D]PYRIMIDIN-6-AMINE(CAS DataBase Reference)
• NIST Chemistry Reference: 4-METHOXY-1H-PYRAZOLO[3,4-D]PYRIMIDIN-6-AMINE(100644-67-5)
• EPA Substance Registry System: 4-METHOXY-1H-PYRAZOLO[3,4-D]PYRIMIDIN-6-AMINE(100644-67-5)

Safety Data

• Hazardous Substances Data: 100644-67-5(Hazardous Substances Data)

Usage

General Description

4-Methoxy-1H-pyrazolo[3,4-d]pyrimidin-6-amine is a chemical compound with a molecular formula of C8H8N6O, which belongs to the class of pyrazolopyrimidine derivatives. 4-METHOXY-1H-PYRAZOLO[3,4-D]PYRIMIDIN-6-AMINE is a yellow solid, and it is primarily used as an intermediate in the synthesis of pharmaceutical drugs. It has potential therapeutic properties and has been studied for its role in treating various health conditions including cancer, cardiovascular diseases, and neurological disorders. Additionally, it is also being investigated for its potential as a kinase inhibitor, which can be useful in the development of new drugs for the treatment of various diseases. Overall, 4-Methoxy-1H-pyrazolo[3,4-d]pyrimidin-6-amine is an important chemical in the field of medicinal chemistry and drug discovery.

Upstream product

• 124-41-4 sodium methylate 
• 100644-65-3 4-chloro-1H-pyrazolo[3,4-d]pyrimidine-6-amine 
• 5604-46-6 2-amino-4,6-dichloropyrimidine-5-carboxaldehyde 
• 100644-65-3 4-chloro-6-aminopyrazolo[3,4-d]pyrimidine 

Downstream Products

• 109737-90-8 6-amino-1-[2'-deoxy-3',5'-di-O-(p-toluoyl)-β-D-erythro-pentofuranosyl]-4-methoxy-1H-pyrazolo[3,4-d]pyrimidine 
• 100644-68-6 6-amino-1-<2'-deoxy-3',5'-di-O-(p-toluoyl)-β-D-erythro-pentofuranosyl>-4-methoxy-1H-pyrazolo<3,4-d>pyrimidine 
• 203180-01-2 6-amino-3-iodo-4-methoxy-1H-pyrazolo[3,4-d]pyrimidine 
• 203180-03-4 6-Amino-3-bromo-1-[2'-deoxy-3',5'-di-O-(p-toluoyl)-β-D-erythro-pentofuranosyl]-4-methoxy-1H-pyrazolo[3,4-d]pyrimidine 
• 203180-05-6 6-Amino-1-[2'-deoxy-3',5'-di-O-(p-toluoyl)-β-D-erythro-pentofuranosyl]-3-iodo-4-methoxy-1H-pyrazolo[3,4-d]pyrimidine 
• 100644-70-0 8-aza-7-deaza-2'-deoxyguanosine 
• 109737-94-2 6-Amino-2-(2'-deoxy-β-D-erythro-pentofuranosyl)-2H-pyrazolo<3,4-d>pyrimidin-4(5H)-one 
• 117818-22-1 6-amino-1-<2',3'-dideoxy-5'-O-(p-toluoyl)-β-D-glycero-pentofuranosyl>-1H-pyrazolo<3,4-d>pyrimidin-4(5H)-one 
• 117818-24-3 6-amino-1-<2'-deoxy-5'-O-(p-toluoyl)-β-D-erythro-pentofuranosyl>-1H-pyrazolo<3,4-d>pyrimidin-4(5H)-one 
• 117818-26-5 6-amino-1-<2'-deoxy-3'-O-(methoxythiocarbonyl)-5'-O-(p-toluoyl)-β-D-erythro-pentofuranosyl>-1H-pyrazolo<3,4-d>pyrimidin-4(5H)-one 
• 117852-20-7 4-Methyl-benzoic acid (2R,3S,5R)-5-(6-amino-4-oxo-4,5-dihydro-pyrazolo[3,4-d]pyrimidin-1-yl)-3-(imidazole-1-carbothioyloxy)-tetrahydro-furan-2-ylmethyl ester 
• 203180-01-2 3-Iodo-4-methoxypyrazolo[3,4-d]pyrimidine-6-ylamine 

Relevant articles and documents

nitrogen hybridization guanine nucleoside and its synthetic method and the use of DNA sequencing

The invention discloses hybrid azaguanosine as well as a synthesis method and an application thereof in DNA sequencing. The synthesis method comprises the steps: removing a protecting group of a compound as shown in formula (III) in the specification under an alkaline condition to obtain a compound as shown in formula (II) in the specification; further demethylating to obtain a compound as shown in formula (I) in the specification, i.e. 7-deaza-7-halogen-8-aza-guanosine, wherein R1 is H or OH, R2 is I, Br or Cl, and R3 is H or a compound shown in the specification. The hybrid azaguanosine disclosed by the invention is a novel reagent for DNA sequencing, which, compared to guanosine failing to substitute nitrogen on 8 sites, is more excellent in base identifying effect and more stable in DNA chain structure. Meanwhile, different from the prior art that 8-site nitrogen-substituted guanosine is complex in synthesis method, low in yield and unsuitable for commercial production, the synthesis method disclosed by the invention is easily available in raw material required, and adopts conventional chemical synthesis reaction; and the method is relatively high in yield, and suitable for wide popularization and application.

Synthesis of 2'-deoxyribofuranosides of 8-aza-7-deazaguanine and related pyrazolo[3,4-d]pyrimidines

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