10066-90-7 Usage
Description
4-ACETAMINOPHEN SULFATE, also known as paracetamol sulfate, is an aryl sulfate that is a metabolite of Acetaminophen. It is characterized by the replacement of the hydroxy group in paracetamol with a sulfooxy group. This light-tan solid possesses unique chemical properties that make it suitable for various applications across different industries.
Uses
Used in Pharmaceutical Industry:
4-ACETAMINOPHEN SULFATE is used as an active pharmaceutical ingredient for the management of mild to moderate pain and fever. Its analgesic and antipyretic properties make it a popular choice in over-the-counter medications and prescription drugs.
Used in Chemical Research:
In the field of chemical research, 4-ACETAMINOPHEN SULFATE serves as a valuable compound for studying the metabolism and pharmacokinetics of Acetaminophen. This helps in understanding its mechanism of action, potential side effects, and ways to improve its therapeutic efficacy.
Used in Drug Formulation:
4-ACETAMINOPHEN SULFATE is used as a key component in the formulation of various drug products, including tablets, capsules, and liquid suspensions. Its light-tan solid form allows for easy incorporation into these formulations, ensuring consistent dosing and improved patient compliance.
Used in Quality Control and Analysis:
In the pharmaceutical quality control and analysis sector, 4-ACETAMINOPHEN SULFATE is utilized as a reference standard for the development and validation of analytical methods. This ensures the accurate quantification and assessment of the compound in drug products, maintaining the safety and efficacy of medications.
Check Digit Verification of cas no
The CAS Registry Mumber 10066-90-7 includes 8 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 5 digits, 1,0,0,6 and 6 respectively; the second part has 2 digits, 9 and 0 respectively.
Calculate Digit Verification of CAS Registry Number 10066-90:
(7*1)+(6*0)+(5*0)+(4*6)+(3*6)+(2*9)+(1*0)=67
67 % 10 = 7
So 10066-90-7 is a valid CAS Registry Number.
InChI:InChI=1/C8H9NO2.H2O4S/c1-6(10)9-7-2-4-8(11)5-3-7;1-5(2,3)4/h2-5,11H,1H3,(H,9,10);(H2,1,2,3,4)
10066-90-7Relevant articles and documents
Monitoring in situ liver metabolism in rats using microdialysis. Comparison of microdialysis mass-transport model predictions to experimental metabolite generation data
Stenken, Julie A.,Stahle, Lars,Lunte, Craig E.,Southard, Marylee Z.
, p. 311 - 320 (1998)
The generation of metabolites from two model compounds, phenacetin and acetaminophen, included in the perfusion fluid of a microdialysis probe implanted into rat liver was studied. When 60 μM phenacetin was included in the perfusion fluid using a flow rate of 1.0 μL/min, acetaminophen and acetaminophen sulfate were recovered at concentrations that ranged between 0.4 and 1.6 μM. Acetaminophen sulfate ([AS](gain)) diffused back into the microdialysis probe on a micromolar percentage basis of 8.9 ± 2.4% (n = 3) when acetaminophen was passed through the probe at a concentration between 11 and 12 μM. When 220-240 μM acetaminophen was passed through the probe, the percentage of acetaminophen sulfate recovered was 4.8 ± 1.4% (n = 3) (P 0.1 compared to the 11 μM group). No acetaminophen glucuronide was detected in the dialysate samples. A mathematical model that describes mass transport in microdialysis sampling was used to predict the concentration of metabolite that could be recovered into the dialysate after the loss of a substrate compound that undergoes metabolism. The model predicts a metabolite recovery of 23.6% using estimates for phenacetin metabolism and 21.5% using estimates for acetaminophen metabolism. The results presented here indicate that microdialysis has potential to be used to study local in situ metabolism and with further refinements of the microdialysis mass-transport model may be used to estimate in vivo metabolic formation rates.
