1006891-33-3

Basic information

• Product Name: CIS-3-BOC-AMINO-TETRAHYDROPYRAN-4-CARBOXYLIC ACID
• Synonyms: CIS-3-BOC-AMINO-TETRAHYDROPYRAN-4-CARBOXYLIC ACID;CIS-3-TERT-BUTOXYCARBONYLAMINO-TETRAHYDRO-PYRAN-4-CARBOXYLIC ACID
• CAS NO: 1006891-33-3
• Molecular Formula: C11H19NO5
• Molecular Weight: 245.27226
• Mol File: 1006891-33-3.mol
• Article Data: 5

Chemical Properties

• Boiling Point: 413.9±45.0 °C(Predicted)
• Appearance: /
• Density: 1.19±0.1 g/cm3(Predicted)
• PKA: 4.18±0.40(Predicted)
• CAS DataBase Reference: CIS-3-BOC-AMINO-TETRAHYDROPYRAN-4-CARBOXYLIC ACID(CAS DataBase Reference)
• NIST Chemistry Reference: CIS-3-BOC-AMINO-TETRAHYDROPYRAN-4-CARBOXYLIC ACID(1006891-33-3)
• EPA Substance Registry System: CIS-3-BOC-AMINO-TETRAHYDROPYRAN-4-CARBOXYLIC ACID(1006891-33-3)

Safety Data

• Hazardous Substances Data: 1006891-33-3(Hazardous Substances Data)

Usage

General Description

CIS-3-BOC-AMINO-TETRAHYDROPYRAN-4-CARBOXYLIC ACID is a chemical compound that consists of a tetrahydropyran ring with an amino group and a carboxylic acid functional group. The BOC (tert-butyloxycarbonyl) group is attached to the amino group, providing protection for the amine functionality during chemical synthesis. CIS-3-BOC-AMINO-TETRAHYDROPYRAN-4-CARBOXYLIC ACID is commonly used in organic synthesis as a building block for the preparation of various pharmaceuticals and agrochemicals. Its unique structure and functional groups make it an important intermediate in the production of complex organic molecules. Additionally, its stability and reactivity make it a valuable tool for the modification of biomolecules in biochemical research.

Upstream product

• 388109-30-6 ethyl (3S,4R)-3-(((1R)-1-phenylethyl)amino)tetrahydro-2H-pyran-4-carboxylate 
• 1363404-85-6 ethyl (3S,4R)-3-((tert-butoxycarbonyl)amino)tetrahydro-2H-pyran-4-carboxylate 
• 324767-92-2 ethyl 5-hydroxy-3,6-dihydro-2H-pyran-4-carboxylate 
• 1343915-25-2 4-(2,2-diethoxyethoxy)but-1-ene 
• 1220327-06-9 2-(but-3-en-1-yloxy)-N-hydroxyethanimine 
• 1220327-09-2 3,3a,4,5-tetrahydro-7H-pyrano[3,4-c][1,2]oxazole 

Downstream Products

• 1350734-62-1 tert-butyl ((3S,4R)-4-aminotetrahydro-2H-pyran-3-yl)carbamate 

Relevant articles and documents

Tetrahydropyran carboxylic acid derivative and synthesis method thereof

The invention belongs to the technical field of organic synthesis, and relates to (3S,4S)-3-(((9H-fluorene-9-yl)methoxy)carbonyl)-tetrahydro-2H-pyran-4-carboxylic acid and a synthesis method thereof.The provided synthetic method comprises the following steps: taking 3-butene-1-ol and 2-bromo-1,1-diethoxyethane as raw materials, and carrying out nine steps: substitution, substitution, cyclization,catalytic hydrogenation, Boc feeding, oxidation, chiral resolution, Boc removal and substitution reaction to prepare (3S, 4S)-3-((((9H-fluorene-9-yl) methoxy) carbonyl)-tetrahydro-2H-pyran-4-carboxylic acid. The synthetic route is simple, the cost is low, the efficiency is high, and the synthesized product can be used as a new medical intermediate.

HETEROCYCLIC COMPOUND

The present invention provide a heterocyclic compound having a HDAC inhibitory action, and useful for the treatment of autoimmune diseases and/or inflammatory diseases, graft versus host disease, cancers, central nervous diseases including neurodegenerative diseases, Charcot-Marie-Tooth disease and the like, and a pharmaceutical composition comprising the compound. The present invention relates to a compound represented by the formula (I): wherein each symbol is as defined in the specification, or a salt thereof.

Cyclic beta-amino acid derivatives as factor Xa inhibitors

The present application describes cyclic β-amino acid derivatives or pharmaceutically acceptable salt forms thereof, wherein the central core is a non-aromatic carbocycle or heterocycle. Compounds of the present invention are useful as inhibitors of trypsin-like serine proteases, specifically factor Xa.