1008-19-1Relevant articles and documents
A sliding cyclohexane rearrangement mediated by zirconium tetrachloride
Harrowven, David C.,Dainty, Richard F.
, p. 3607 - 3608 (1996)
6-Methoxytetralins may be smoothly transformed into 5-methoxytetralins through the action of zirconium tetrachloride. The rearrangement occurs at ambient temperature in chloroform and proceeds via fragmentation of the carbon-carbon bond para to the methoxy substituent followed by an intramolecular Friedel-Crafts alkylation.
Birch-Type Photoreduction of Arenes and Heteroarenes by Sensitized Electron Transfer
Chatterjee, Anamitra,K?nig, Burkhard
, p. 14289 - 14294 (2019)
The direct reduction of arenes and heteroarenes by visible-light irradiation remains challenging, as the energy of a single photon is not sufficient for breaking aromatic stabilization. Shown herein is that the energy accumulation of two visible-light photons allows the dearomatization of arenes and heteroarenes. Mechanistic investigations confirm that the combination of energy-transfer and electron-transfer processes generates an arene radical anion, which is subsequently trapped by hydrogen-atom transfer and finally protonated to form the dearomatized product. The photoreduction converts planar aromatic feedstock compounds into molecular skeletons that are of use in organic synthesis.
Alkyl Carbagermatrane Enabled Synthesis of Seven-Membered Carbocycle-Fused Aromatics through Catellani Strategy
Xie, Xiu-Ying,Jiang, Wei-Tao,Xiao, Bin
, p. 2819 - 2827 (2021/06/02)
Synthesis of seven-membered carbocycle-fused aromatics was realized by Catellani reaction using terminally brominated alkyl carbagermatranes through intermolecular cyclization manner. Various functional groups were well tolerated, and this transformation was also expanded to the synthesis of carbocycles of other size. The utility of this method was demonstrated by modification of natural product derivatives and synthesis of bioactive molecules.
Method for hydrogenolysis of halides
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, (2021/01/11)
The invention discloses a method for hydrogenolysis of halides. The invention discloses a preparation method of a compound represented by a formula I. The preparation method comprises the following step: in a polar aprotic solvent, zinc, H2O and a compound represented by a formula II are subjected to a reaction as shown in the specification, wherein X is halogen; Y is -CHRR or R; hydrogenin H2O exists in the form of natural abundance or non-natural abundance. According to the preparation method, halide hydrogenolysis can be simply, conveniently and efficiently achieved through a simple and mild reaction system, and good functional group compatibility and substrate universality are achieved.