1008-95-3

Basic information

• Product Name: 4-(1,3-OXAZOL-5-YL)ANILINE
• Synonyms: 4-(5-Oxazolyl)aniline;4-(oxazol-5-yl)aniline;4-(1,3-Oxazol-5-yl);4-(1,3-OXAZOL-5-YL)ANILINE;5-(4-AMINOPHENYL)OXAZOLE;4-(1,3-Oxazol-5-yl)aniline, tech
• CAS NO: 1008-95-3
• Molecular Formula: C₉H₈N₂O
• Molecular Weight: 160.17
• Product Categories: Phenyls & Phenyl-Het;Phenyls & Phenyl-Het;Amines and Anilines;Heterocycles;Amines
• Mol File: 1008-95-3.mol
• Article Data: 12

Chemical Properties

• Melting Point: 150 °C
• Boiling Point: 318.7 °C at 760 mmHg
• Flash Point: 146.5 °C
• Appearance: /
• Density: 1.204 g/cm³
• Vapor Pressure: 0.000356mmHg at 25°C
• Refractive Index: 1.599
• Storage Temp.: Keep in dark place,Inert atmosphere,Room temperature
• PKA: 3.46±0.10(Predicted)
• CAS DataBase Reference: 4-(1,3-OXAZOL-5-YL)ANILINE(CAS DataBase Reference)
• NIST Chemistry Reference: 4-(1,3-OXAZOL-5-YL)ANILINE(1008-95-3)
• EPA Substance Registry System: 4-(1,3-OXAZOL-5-YL)ANILINE(1008-95-3)

Safety Data

• Hazard Codes: Xi,Xn
• Statements: 36/37/38-36-22
• Safety Statements: 26-36/37/39
• HazardClass: IRRITANT
• Hazardous Substances Data: 1008-95-3(Hazardous Substances Data)

Usage

General Description

4-(1,3-oxazol-5-yl)aniline, also known as 5-(4-aminophenyl)-1,3-oxazole, is a chemical compound with the molecular formula C9H8N2O. It is a heterocyclic compound that contains both an aniline and an oxazole moiety. The compound is commonly used in medicinal and pharmaceutical research, as well as in organic synthesis. It has been studied for its potential as a building block in the synthesis of bioactive compounds and as a potential inhibitor of certain enzymes. Additionally, 4-(1,3-oxazol-5-yl)aniline has been found to exhibit antimicrobial and anti-inflammatory properties, making it a subject of interest for further exploration in drug development and disease treatment.

InChI:InChI=1/C9H8N2O/c10-8-3-1-7(2-4-8)9-5-11-6-12-9/h1-6H,10H2

Upstream product

• 267648-15-7 5-(2-bromo-4-nitrophenyl)oxazole 
• 5274-71-5 2-bromo-4-nitro-benzaldehyde 
• 7745-93-9 2-bromo-4-nitrotoluene 
• 470715-98-1 acetic acid acetoxy-(2-bromo-4-nitro-phenyl)-methyl ester 
• 38622-91-2 [(p-methylphenyl)sulfonylmethyl]isonitrile 
• 555-16-8 4-nitrobenzaldehdye 
• 1014-23-9 5-(4-nitrophenyl)oxazole 
• 7439-89-6 iron 
• 1186127-11-6 5-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)-2-(triisopropylsilyl)-1,3-oxazole 

Downstream Products

• 470716-09-7 N-(4-oxazol-5-yl-phenyl)-oxalamic acid 
• 333728-92-0 C₁₉H₁₃N₇O₂ 
• 738570-45-1 (4-oxazol-5-yl-phenyl)-hydrazine 
• 1079054-20-8 2-chloro-4-(oxazol-5-yl)aniline 
• 1146977-43-6 N-ethyl-N'-[4-(1,3-oxazol-5-yl)phenyl]thiourea 
• 1226887-03-1 1-(4-(oxazol-5-yl)phenyl)guanidine 
• 1243268-60-1 cyclobutanecarboxylic acid {3-[2-(4-oxazol-5-yl-phenylamino)-pyrrolo[2,3-d]pyrimidin-7-yl]-propyl}-amide 
• 1312558-73-8 1-[4-(4-methyl-piperazin-1-yl)-phenyl]-3-(4-oxazol-5-yl-phenyl)-urea 
• 1377264-40-8 1-(4-ethylpyridin-2-yl)-3-(4-(oxazol-5-yl)phenyl)thiourea 
• 1454771-59-5 C₂₄H₂₅N₅O₂ 
• 1610874-78-6 2-(2-chlorophenyl)-N-(4-(oxazol-5-yl)phenyl)acetamide 

Relevant articles and documents

Cyclic (Alkyl)(amino)carbene Ligand-Promoted Nitro Deoxygenative Hydroboration with Chromium Catalysis: Scope, Mechanism, and Applications

Transition metal catalysis that utilizes N-heterocyclic carbenes as noninnocent ligands in promoting transformations has not been well studied. We report here a cyclic (alkyl)(amino)carbene (CAAC) ligand-promoted nitro deoxygenative hydroboration with cost-effective chromium catalysis. Using 1 mol % of CAAC-Cr precatalyst, the addition of HBpin to nitro scaffolds leads to deoxygenation, allowing for the retention of various reducible functionalities and the compatibility of sensitive groups toward hydroboration, thereby providing a mild, chemoselective, and facile strategy to form anilines, as well as heteroaryl and aliphatic amine derivatives, with broad scope and particularly high turnover numbers (up to 1.8 × 106). Mechanistic studies, based on theoretical calculations, indicate that the CAAC ligand plays an important role in promoting polarity reversal of hydride of HBpin; it serves as an H-shuttle to facilitate deoxygenative hydroboration. The preparation of several commercially available pharmaceuticals by means of this strategy highlights its potential application in medicinal chemistry.

Method for preparing amine through catalytic reduction of nitro compound by cyclic (alkyl) (amino) carbene chromium complex

The cyclic (alkyl) (amino) carbene chromium complex is prepared from corresponding ligand salt, alkali and CrCl3 and used for catalyzing pinacol borane to reduce nitro compounds in an ether solvent under mild conditions to generate corresponding amine. The method for preparing amine has the advantages of cheap and accessible raw materials, mild reaction conditions, wide substrate application range, high selectivity and the like, and is simple to operate.

HETEROARYL RHEB INHIBITORS AND USES THEREOF

The present invention provides compounds, compositions thereof, and methods of using the same. Compositions comprising a compound of this invention or a pharmaceutically acceptable derivative thereof and a pharmaceutically acceptable carrier, adjuvant, or vehicle. The amount of the compound in compositions of this invention is such that it is effective to measurably inhibit Rheb, in a biological sample or in a patient.