100861-38-9 Usage
Description
3-METHOXY-4-METHYLPHENYLACETIC ACID is an organic compound that is synthetically prepared through a specific chemical process involving benzylic metalation of substituted toluenes. This process utilizes a mixed metal (Li/K) amide base to facilitate an anion migration from the kinetic to the benzylic metalation site, resulting in the formation of this unique compound.
Uses
Used in Chemical Synthesis:
3-METHOXY-4-METHYLPHENYLACETIC ACID is used as a key intermediate in the chemical synthesis of various pharmaceuticals and other organic compounds. Its unique structure allows it to be a valuable building block for the creation of a wide range of products.
Used in Pharmaceutical Industry:
In the pharmaceutical industry, 3-METHOXY-4-METHYLPHENYLACETIC ACID is used as a starting material for the development of new drugs. Its specific functional groups and structural features make it a promising candidate for the synthesis of novel therapeutic agents.
Used in Research and Development:
3-METHOXY-4-METHYLPHENYLACETIC ACID is also utilized in research and development settings, where it can be employed to study various chemical reactions and explore its potential applications in different fields, such as materials science and biotechnology.
Used in Custom Synthesis Services:
3-METHOXY-4-METHYLPHENYLACETIC ACID is used as a custom synthesis service for clients who require specific quantities or modifications of 3-METHOXY-4-METHYLPHENYLACETIC ACID for their unique applications, allowing for tailored production to meet specific project needs.
Check Digit Verification of cas no
The CAS Registry Mumber 100861-38-9 includes 9 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 6 digits, 1,0,0,8,6 and 1 respectively; the second part has 2 digits, 3 and 8 respectively.
Calculate Digit Verification of CAS Registry Number 100861-38:
(8*1)+(7*0)+(6*0)+(5*8)+(4*6)+(3*1)+(2*3)+(1*8)=89
89 % 10 = 9
So 100861-38-9 is a valid CAS Registry Number.
InChI:InChI=1/C10H12O3/c1-7-3-4-8(6-10(11)12)5-9(7)13-2/h3-5H,6H2,1-2H3,(H,11,12)
100861-38-9Relevant articles and documents
Nucleoside analogs useful as PRMT5 inhibitors
-
Paragraph 0548; 0549; 0550; 0551, (2021/08/11)
The invention relates to the technical field of biological medicines, and particularly discloses a nucleoside analogue used as a PRMT5 inhibitor. According to the nucleoside analogue as shown in the formula (I) or the pharmaceutically acceptable salt of the nucleoside analogue, the nucleoside analogue or the pharmaceutically acceptable salt of the nucleoside analogue shows relatively high inhibition on the activity of PRMT5 and can be used for preventing and/or treating PRMT5-mediated diseases, and the PRMT5-mediated diseases comprise cell abnormal proliferative diseases.
Controlled anion migrations with a mixed metal Li/K-TMP amide: General application to benzylic metalations
Fleming, Patricia,Oshea, Donal F.
supporting information; experimental part, p. 1698 - 1701 (2011/04/17)
A general method is described for benzylic metalation of o-, m-, and p-substituted toluenes using a mixed metal amide base generated from BuLi/KOtBu/TMP at -78 °C in THF. The excellent selectivity achieved can be rationalized by the ability of the mixed metal amide base to facilitate an anion migration from the kinetic (o-aryl) to the benzylic metalation site. Remarkably, this controlled anion migration is achievable with catalytic amounts of TMP at -78 °C.
ARYL AND HETEROARYL TETRAHYDROBENZAZEPINE DERIVATIVES AND THEIR USE FOR TREATING GLAUCOMA
-
Page/Page column 7, (2010/11/29)
Aryl tetrahydrobenzazepine derivatives with minimal 5-HT2B activity relative to 5-HT2A and 5-HT2C activity that are useful for treating glaucoma are disclosed.