1009119-65-6 Usage
Description
N,N'-[[1,1'-Biphenyl]-4,4'-diylbis[1H-imidazole-5,2-diyl-(2S)-2,1-pyrrolidinediyl[(1S)-1-(1-methylethyl)-2-oxo-2,1-ethanediyl]]]biscarbamic acid dimethyl ester hydrochloride is a complex organic compound with a unique structure that features a biphenyl core connected to imidazole and pyrrolidine rings through carbamate linkages. N,N'-[[1,1'-Biphenyl]-4,4'-diylbis[1H-imidazole-5,2-diyl-(2S)-2,1-pyrrolidinediyl[(1S)-1-(1-methylethyl)-2-oxo-2,1-ethanediyl]]]biscarbamic acid dimethyl ester hydrochloride is characterized by its hydrochloride salt form, which may contribute to its solubility and stability in certain conditions.
Uses
There is no specific information provided in the materials about the uses of N,N'-[[1,1'-Biphenyl]-4,4'-diylbis[1H-imidazole-5,2-diyl-(2S)-2,1-pyrrolidinediyl[(1S)-1-(1-methylethyl)-2-oxo-2,1-ethanediyl]]]biscarbamic acid dimethyl ester hydrochloride. However, given its structural features, it may have potential applications in various fields such as pharmaceuticals, materials science, or as a chemical intermediate. Further research and development would be required to explore and confirm its specific uses and benefits in different industries.
Synthesis
Bromination of commercial 4,40-diacetylbiphenyl (58) gave
4,40-bis(bromoacetyl)biphenyl 59 in 82% yield. Alkylation of NBoc-
L-proline (60) with 59 gave diester 61 which was treated with
ammonium acetate to effect cyclization of the bis-ketoester to provide
bis-imidazole 62 in 63% yield for the two steps. Acidic removal
of the Boc protecting groups followed by recrystallization provided
bis-pyrrolidine 63 in high yield. Acylation of 63 with N-(methoxycarbonyl)-
L-valine (64) using N-(3-dimethylaminopropyl)-N0-ethylcarbodiimide
(EDC) and 1-hydroxybenxotriazole hydrate (HOBT)
provided declatasvir. The dihydrochloride salt was prepared and
treated with Cuno Zet Carbon ? followed by crystallization from acetone
to give daclatasvir dihydrochloride (IX) in 74% yield.
Mode of action
Daclatasvir is an inhibitor of nonstructural protein 5A (NS5A), a multifunctional protein that is an essential component of the HCV replication complex. Daclatasvir binds to the N-terminus of NS5A and inhibits both viral RNA replication and virion assembly.
Check Digit Verification of cas no
The CAS Registry Mumber 1009119-65-6 includes 10 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 7 digits, 1,0,0,9,1,1 and 9 respectively; the second part has 2 digits, 6 and 5 respectively.
Calculate Digit Verification of CAS Registry Number 1009119-65:
(9*1)+(8*0)+(7*0)+(6*9)+(5*1)+(4*1)+(3*9)+(2*6)+(1*5)=116
116 % 10 = 6
So 1009119-65-6 is a valid CAS Registry Number.