1011-17-2 Usage
Description
1-(2-Hydroxyphenyl)piperazine, also known as 2-(Piperazin-1-yl)phenol, is an organic compound with a brown-pink to brown color in the form of powder and chunks. It is characterized by its chemical structure that includes a phenyl ring with a hydroxyl group and a piperazine ring, which contributes to its unique properties and potential applications in various fields.
Uses
Used in Pharmaceutical Industry:
1-(2-Hydroxyphenyl)piperazine is used as an intermediate compound for the synthesis of substituted imidazoles and oxazoles, which are important in the treatment of various cancers and other medical conditions. Its chemical structure allows for the development of novel therapeutic agents that can target specific biological pathways involved in disease progression.
Used in Chemical Synthesis:
1-(2-Hydroxyphenyl)piperazine serves as a versatile building block in the synthesis of a wide range of chemical compounds, including pharmaceuticals, agrochemicals, and other specialty chemicals. Its unique structure and reactivity make it a valuable component in the development of new molecules with potential applications in various industries.
Used in Research and Development:
Due to its unique chemical properties and potential for modification, 1-(2-Hydroxyphenyl)piperazine is utilized in research and development for the exploration of new chemical reactions, synthesis methods, and the discovery of novel compounds with specific biological activities. Its use in this context contributes to the advancement of scientific knowledge and the development of innovative solutions in various fields.
Check Digit Verification of cas no
The CAS Registry Mumber 1011-17-2 includes 7 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 4 digits, 1,0,1 and 1 respectively; the second part has 2 digits, 1 and 7 respectively.
Calculate Digit Verification of CAS Registry Number 1011-17:
(6*1)+(5*0)+(4*1)+(3*1)+(2*1)+(1*7)=22
22 % 10 = 2
So 1011-17-2 is a valid CAS Registry Number.
InChI:InChI=1/C10H14N2O/c13-10-4-2-1-3-9(10)12-7-5-11-6-8-12/h1-4,11,13H,5-8H2/p+1
1011-17-2Relevant articles and documents
Identification of novel GLUT inhibitors
Siebeneicher, Holger,Bauser, Marcus,Buchmann, Bernd,Heisler, Iring,Müller, Thomas,Neuhaus, Roland,Rehwinkel, Hartmut,Telser, Joachim,Zorn, Ludwig
, p. 1732 - 1737 (2016/07/27)
The compound class of 1H-pyrazolo[3,4-d]pyrimidines was identified using HTS as very potent inhibitors of facilitated glucose transporter 1 (GLUT1). Extensive structure–activity relationship studies (SAR) of each ring system of the molecular framework was established revealing essential structural motives (i.e., ortho-methoxy substituted benzene, piperazine and pyrimidine). The selectivity against GLUT2 was excellent and initial in vitro and in vivo pharmacokinetic (PK) studies are encouraging.
CYCLOHEXYLDIAMINES AS SELECTIVE ALPHA 1A/1D ADRENORECEPTOR ANTAGONISTS FOR THE TREATMENT OF BENIGN PROSTATE HYPERTROPHY AND LOWER URINARY TRACT SYMPTOMS
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Page/Page column 72-74, (2010/11/30)
The present invention relates to compounds of Formula (I) or a pharmaceutically acceptable form thereof, as dual selective a1a / a 1d adrenoreceptor antagonists for the treatment of benign prostatic hypertrophy and lower urinary tract symptoms. The present invention also relates to pharmaceutical compositions comprising said new compounds, new processes to prepare these new compounds and new uses as a medicine as well as method of treatments.
New μ-opioid receptor agonists with piperazine moiety
Komoto,Okada,Sato,Niino,Oka,Sakamoto
, p. 1314 - 1320 (2007/10/03)
New μ-opioid receptor (MOR) agonists containing piperazine and homopiperazine moieties in the structures were synthesized and their affinities to and agonist potencies on MOR were evaluated. Among the synthesized compounds, 4-[4-(2-methoxyphenyl)piperazin-1-yl]-N,N-dimethyl-2,2-diphenylbutanamide (20Aa) showed the highest affinity to the human MOR expressed in Chinese hamster ovary (CHO)-K1 cells, and the highest agonist potency on the MOR in isolated guinea-pig ileum preparation.