101110-09-2

Basic information

• Product Name: 6-(4-hydroxyphenyl)-3,4-dihydronaphthalen-1(2H)-one
• Synonyms: 6-(4-hydroxyphenyl)-3,4-dihydronaphthalen-1(2H)-one
• CAS NO: 101110-09-2
• Molecular Weight: 238.286
• Mol File: 101110-09-2.mol
• Article Data: 4

Chemical Properties

• CAS DataBase Reference: 6-(4-hydroxyphenyl)-3,4-dihydronaphthalen-1(2H)-one(CAS DataBase Reference)
• NIST Chemistry Reference: 6-(4-hydroxyphenyl)-3,4-dihydronaphthalen-1(2H)-one(101110-09-2)
• EPA Substance Registry System: 6-(4-hydroxyphenyl)-3,4-dihydronaphthalen-1(2H)-one(101110-09-2)

Safety Data

• Hazardous Substances Data: 101110-09-2(Hazardous Substances Data)

Upstream product

• 3470-50-6 6-Hydroxy-1-tetralone 
• 101594-72-3 6-(4-methoxy-phenyl)-3,4,7,8-tetrahydro-2H-naphthalen-1-one 
• 144464-64-2 5-oxo-5,6,7,8-tetrahydronaphthalen-2-yl trifluoromethanesulfonate 
• 159191-56-7 (4-((tert-butyldimethylsilyl)oxy)phenyl)boronic acid 
• 100-66-3 methoxybenzene 
• 529-34-0 3,4-dihydronaphthalene-1(2H)-one 
• 101596-86-5 6-(4-methoxyphenyl)-3,4-dihydronaphthalen-1(2H)-one 

Downstream Products

• 1356059-01-2 6-(4-hydroxyphenyl)-3,4,4',5'-tetrahydro-2H-spiro[naphthalene-1,2'-pyran]-6'(3'H)-one 
• 1356698-22-0 1-(4-hydroxybutyl)-6-(4-hydroxyphenyl)-1,2,3,4-tetrahydronaphthalen-1-ol 
• 1356058-52-0 1-but-3-en-1-yl-6-(4-hydroxyphenyl)-1,2,3,4-tetrahydronaphthalen-1-ol 

Relevant articles and documents

Novel inhibitors of 17β-hydroxysteroid dehydrogenase type 1: Templates for design

The 17β-hydroxysteroid dehydrogenases (17β-HSDs) catalyze the interconversion between the oxidized and reduced forms of androgens and estrogens at the 17 position. The 17β-HSD type 1 enzyme (17β-HSD1) catalyzes the reduction of estrone (E1) to estradiol a

ERβ ligands. 3. Exploiting two binding orientations of the 2-phenylnaphthalene scaffold to achieve ERβ selectivity

The 2-phenylnaphthalene scaffold was explored as a simplified version of genistein in order to identify ER selective ligands. With the aid of docking studies, positions 1, 4, and 8 of the 2-phenylnaphthalene template were predicted to be the most potentially influential positions to enhance ER selectivity using two different binding orientations. Both orientations have the phenol moiety mimicking the A-ring of genistein. Several compounds predicted to adopt orientations similar to that of genistein when bound to ERβ were observed to have slightly higher ER affinity and selectivity than genistein. The second orientation we exploited, which was different from that of genistein when bound to ERβ, resulted in the discovery of several compounds that had superior ER selectivity and affinity versus genistein. X-ray structures of two ER selective compounds (i.e., 15 and 47) confirmed the alternate binding mode and suggested that substituents at positions 1 and 8 were responsible for inducing selectivity. One compound (i.e., 47, WAY-202196) was further examined and found to be effective in two models of inflammation, suggesting that targeting ER may be therapeutically useful in treating certain chronic inflammatory diseases.