1012918-35-2

Basic information

• Product Name: 2-(diethylamino)-N-(4-trifluoromethyl-phenyl)acetamide
• Synonyms: 2-(diethylamino)-N-(4-trifluoromethyl-phenyl)acetamide
• CAS NO: 1012918-35-2
• Molecular Weight: 274.286
• Mol File: 1012918-35-2.mol
• Article Data: 2

Chemical Properties

• CAS DataBase Reference: 2-(diethylamino)-N-(4-trifluoromethyl-phenyl)acetamide(CAS DataBase Reference)
• NIST Chemistry Reference: 2-(diethylamino)-N-(4-trifluoromethyl-phenyl)acetamide(1012918-35-2)
• EPA Substance Registry System: 2-(diethylamino)-N-(4-trifluoromethyl-phenyl)acetamide(1012918-35-2)

Safety Data

• Hazardous Substances Data: 1012918-35-2(Hazardous Substances Data)

Upstream product

• 30280-35-4 N,N-diethylglycine methyl ester 
• 2707-23-5 2-chloro-N-(4-trifluomethylphenyl)acetamide 
• 109-89-7 diethylamine 

Relevant articles and documents

Nickel-Catalyzed Amide Bond Formation from Methyl Esters

Despite being one of the most important and frequently run chemical reactions, the synthesis of amide bonds is accomplished primarily by wasteful methods that proceed by stoichiometric activation of one of the starting materials. We report a nickel-catalyzed procedure that can enable diverse amides to be synthesized from abundant methyl ester starting materials, producing only volatile alcohol as a stoichiometric waste product. In contrast to acid- and base-mediated amidations, the reaction is proposed to proceed by a neutral cross coupling-type mechanism, opening up new opportunities for direct, efficient, chemoselective synthesis.