101327-87-1

Basic information

• Product Name: 8-Nitro-7-quinolinecarboxaldehyde
• Synonyms: 8-Nitro-7-quinolinecarboxaldehyde;7-Formyl-8-nitroquinoline;8-Nitroquinoline-7-carboxaldehyde;8-Nitro-7-quinolinecarbaldehyde
• CAS NO: 101327-87-1
• Molecular Formula: C₁₀H₆N₂O₃
• Molecular Weight: 202.168
• Mol File: 101327-87-1.mol
• Article Data: 6

Chemical Properties

• Melting Point: 178.0 to 182.0 °C
• Boiling Point: 401.388°C at 760 mmHg
• Flash Point: 196.553°C
• Appearance: /
• Density: 1.441g/cm³
• Vapor Pressure: 0mmHg at 25°C
• Refractive Index: 1.721
• PKA: -0.66±0.31(Predicted)
• CAS DataBase Reference: 8-Nitro-7-quinolinecarboxaldehyde(CAS DataBase Reference)
• NIST Chemistry Reference: 8-Nitro-7-quinolinecarboxaldehyde(101327-87-1)
• EPA Substance Registry System: 8-Nitro-7-quinolinecarboxaldehyde(101327-87-1)

Safety Data

• Hazardous Substances Data: 101327-87-1(Hazardous Substances Data)

Usage

General Description

8-Nitro-7-quinolinecarboxaldehyde is a chemical compound with the molecular formula C10H6N2O3. It is a nitro-aromatic compound that is commonly used in organic synthesis and as a fluorescent probe in bioanalytical applications. The nitro group in the compound allows for potential reactivity in various chemical reactions, while the quinoline structure contributes to its fluorescent properties. 8-Nitro-7-quinolinecarboxaldehyde has been studied for its potential use in the development of pharmaceuticals, as well as in the field of materials science for its fluorescent and luminescent properties. Additionally, it has been investigated for its potential antimicrobial and antiparasitic properties.

InChI:InChI=1/C10H6N2O3/c13-6-8-4-3-7-2-1-5-11-9(7)10(8)12(14)15/h1-6H

Upstream product

• 122947-89-1 7-Dibromomethyl-8-nitro-quinoline 
• 101327-83-7 7-nitromethyl-8-nitroquinolin 
• 176853-39-7 7-<β-trans-(N,N-dimethylamino)ethenyl>-8-nitroquinoline 
• 7471-63-8 8-nitro-7-methylquinoline 
• 607-35-2 8-nitroquinoline 
• 612-60-2 7-methylquinoline 
• 56-81-5 glycerol 
• 107-02-8 acrolein 

Downstream Products

• 158753-17-4 8-amino-7-quinolinecarbaldehyde 
• 109559-47-9 2-phenyl-1,10-phananthroline 
• 1394084-87-7 (8-nitro-quinolin-7-yl)-phenyl-methanol 
• 1394084-96-8 (3-fluoro-phenyl)-(8-nitro-quinolin-7-yl)-methanol 
• 1394084-83-3 7-phenylaminomethyl-quinolin-8-ylamine 
• 1394084-88-8 (8-amino-quinolin-7-yl)-phenyl-methanol 
• 1394082-45-1 2-Methyl-1-phenyl-1,4-dihydro-2H-3-thia-2,4,5-triaza-phenanthrene 3,3-dioxide 
• 1394084-82-2 (8-nitro-quinolin-7-ylmethyl)-phenyl-amine 
• 1394085-12-1 (3-fluoro-phenyl)-(8-nitro-quinolin-7-yl)-methanone 
• 1394085-43-8 (3-[1,3]dioxolan-2-yl-4-fluoro-phenyl)-(8-nitro-quinolin-7-yl)-methanol 
• 1394082-43-9 2-Phenyl-1,4-dihydro-2H-3-thia-2,4,5-triaza-phenanthrene 3,3-dioxide 

Relevant articles and documents

Design and synthesis of chiral 1,10-phenanthroline ligand, and application in palladium catalyzed asymmetric 1,4-addition reactions

Pd-catalyzed asymmetric 1,4-addition of phenylboronic acid to α,β-unsaturated carbonyl compounds was developed using chiral 1,10-phenanthroline derivative as ligand. Good yields (up to 97%), and high enantioselectivities (up to 97% ee) were achieved.

Novel Sulfonaminoquinoline Hepcidin Antagonists

The present invention relates to novel hepcidin antagonists, pharmaceutical compositions comprising them and the use thereof as medicaments for the use in the treatment of iron metabolism disorders, such as, in particular, iron deficiency diseases and anemias, in particular anemias in connection with chronic inflammatory diseases.

Dihalomethylation of Nitroarenes via Vicarious Nucleophilic Substitution of Hydrogen with Trihalomethyl Carbanions

Trichloro- and tribromomethyl carbanions generated by deprotonation of haloforms with potassium tert-butoxide in a THF-DMF mixture at ca. -70 deg C react with a variety of carbocyclic and heterocyclic nitroarenes according to the vicarious nucleophilic substitution scheme.The reaction provides an efficient and convenient way for the direct introduction of dihalomethyl substituents ortho and para to the nitro group, which in turn can be hydrolyzed to produce nitroaryl aldehydes.