101337-87-5

Basic information

• Product Name: N-desmethylrufloxacin
• Synonyms: N-desmethylrufloxacin
• CAS NO: 101337-87-5
• Molecular Formula: C16H16FN3O3S
• Molecular Weight: 349.3799432
• Mol File: 101337-87-5.mol
• Article Data: 3

Chemical Properties

• Boiling Point: 605.1°C at 760 mmHg
• Flash Point: 319.8°C
• Appearance: /
• Density: 1.58g/cm³
• Vapor Pressure: 1.7E-15mmHg at 25°C
• Refractive Index: 1.731
• CAS DataBase Reference: N-desmethylrufloxacin(CAS DataBase Reference)
• NIST Chemistry Reference: N-desmethylrufloxacin(101337-87-5)
• EPA Substance Registry System: N-desmethylrufloxacin(101337-87-5)

Safety Data

• Hazardous Substances Data: 101337-87-5(Hazardous Substances Data)

Usage

InChI:InChI=1/C16H16FN3O3S/c17-11-7-9-12-15(13(11)19-3-1-18-2-4-19)24-6-5-20(12)8-10(14(9)21)16(22)23/h7-8,18H,1-6H2,(H,22,23)

Upstream product

• 101337-86-4 8-Fluoro-1,6-dioxo-9-piperazin-1-yl-2,3-dihydro-1H,6H-1λ⁴-thia-3a-aza-phenalene-5-carboxylic acid 
• 101363-10-4 rufloxacin 
• 367-21-5 3-chloro-4-fluorophenylamine 
• 101337-96-6 8-chloro-7-fluoro-3,4-dihydro-2H-1,4-benzothiazine 
• 101337-95-5 8-chloro-7-fluoro-3-oxo-3,4-dihydro-2H-1,4-benzothiazine 
• 101337-81-9 10-chloro-9-fluoro-7-oxo-2,3-dihydro-7H-pyrido<1,2,3-de><1,4>benzothiazine-6-carboxylic acid 
• 101337-84-2 10-chloro-9-fluoro-7-oxo-2,3-dihydro-7H-pyrido<1,2,3-de><1,4>benzothiazine-6-carboxylic acid 1-oxide 
• 101337-97-7 ethyl 10-chloro-9-fluoro-7-oxo-2,3-dihydro-7H-pyrido<1,2,3-de><1,4>benzothiazine-6-carboxylate 

Relevant articles and documents

Photoinduced N-demethylation of rufloxacin and its methyl ester under aerobic conditions

Irradiation of rufloxacin (RF) under aerobic conditions gives rise to N-demethylation of the piperazinyl ring, which is enhanced in aerated D2O. Two primary processes seem to be involved in RF N-demethylation: photoionization from 1RF and singlet oxygen generation from 3RF. Both processes may lead to the same key intermediates, namely, RF-+ and superoxide radical anion; coupling of these intermediates explains N-demethylation of RF via an iminium cation. Formation of the hydrated electron by a monophotonic process (with a quantum yield of 0.09) is detected along with 3RF (with a intersystem-crossing quantum yield πISC = 0.36) by laser flash photolysis. Studies performed on RF methyl ester give qualitatively similar results.

Derivatives of pyrido-benzothiazine with high anti-microbial activity

Pyrido-benzothiazine compounds having anti-microbial activity are prepared by (a) reacting 3-chloro-4-fluoroaniline with potassium thiocyanate and bromine to produce 2-amino-6-fluoro-7-chlorobenzothiazole, (b) reacting 2-amino-6-fluoro-7-chlorobenzothiazole with sodium hydroxide to produce the disulfide of 2-amino-5-fluoro 6-chlorothiophenol, (c) reacting the disulfide with sodium monochloroacetate to produce 7-fluoro-8-chloro-2H-1,4-benzothiazin-3(4H)-one, (d) reducing 7-fluoro-8-chloro-2H-1,4-benzothiazin-3(4H)-one to produce 7-fluoro-8-chloro-3,4-dihydro-2H-1,4-benzothiazone, (e) reacting 7-fluoro-8-chloro-3,4-dihydro-2-H-1,4-benzothiazone with ethyl ethoxymethylenemalonate and cyclyzing the intermediate formed with polyphosphoric acid to produce ethyl 9-fluoro-10-chloro-7-oxo-2,3-dihydro-7H-pyrido[1,2,3 de] [1,4]-benzothiazine-6-carboxylate and (f) hydrolyizing the ethyl carboxylate to produce the corresponding carboxylic acid.