1016214-10-0Relevant articles and documents
Process for the preparation of carvedilol
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Page/Page column 5, (2008/06/13)
Disclosed herein is a process for preparation of carvedilol substantially free from its bis-impurity comprises the reaction of 4- (2,3- epoxypropoxy)carbazole and 2-(2-methoxyphenoxy)ethylamine in a polar aprotic solvent media; followed by isolation of carvediol from the reaction mass as an acid addition salt and subsequent conversion into pure carvedilol.