101817-20-3Relevant articles and documents
Synthesis and evaluation of a photoactive probe with a multivalent carbohydrate for capturing carbohydrate-lectin interactions
Chang, Tsung-Che,Lai, Chian-Hui,Chien, Chih-Wei,Liang, Chien-Fu,Adak, Avijit Kumar,Chuang, Yung-Jen,Chen, Yu-Ju,Lin, Chun-Cheng
, p. 1895 - 1906 (2014/01/06)
Lectins are ubiquitous carbohydrate-binding proteins of nonimmune origin that are characterized by their specific recognition of defined monosaccharide or oligosaccharide structures. However, the use of carbohydrates to study lectin has been restricted by the weak binding affinity and noncovalent character of the interaction between carbohydrates and lectin. In this report, we designed and synthesized a multifunctional photoaffinity reagent composed of a trialkyne chain, a masked latent amine group, and a photoreactive 3-trifluoromethyl-3- phenyl-diazirine group in high overall yield. Two well-defined chemistries, Huisgen-Sharpless click chemistry and amide bond coupling, were the key steps for installing the multivalent character and tag in our designed photoaffinity probe. The photolabeling results demonstrated that the designed probe selectively labeled the target lectin, RCA120 (Ricinus communis Agglutinin), in an E. coli lysate and an asialoglycoprotein receptor (ASGP-R) on intact HepG2 cell membranes. Moreover, the probe also enabled the detection of weak protein-protein interactions between RCA120 and ovalbumin (OVA).
SYNTHESIS OF ENKEPHALIN ANALOGS. PART IV. N-ALKYLATED DERIVATIVES
Paruszewski, Ryszard,Matusiak, Roza,Rostafinska-Suchar, Grazyna,Gumulka, Stanislaw,Misterek, Krystyna,Dorociak, Anna
, p. 361 - 368 (2007/10/02)
Four new derivatives of enkephalin analogs: H-PrTyr-D-Met-Gly-Phe-εAhx-εAhx-OH (24).H-iPrTyr-D-Met-Gly-Phe-εAhx-εAhx-Oh (25).H-Pr-Tyr-D-Met-Gly-Phe-εAhx-OH (30) and H-iPrTyr-D-Met-Gly-Phe-εAhx-OH (31) have been synthesized and tested for agonistic, antagonistic and analgesic activity.Compound 24 showed a moderate μ agonistic potency and high selectivity.
Synthesis of Cyclic and Cyclically Branched Tachykinine Partial Sequences. Part 3: Synthesis of the cyclo and of Two Ring-Expanded Analogues
Neubert, K.,Hartrodt, Bianka,Berger, Edith,Mehlis, B.,Rueger, Margitta,et al.
, p. 617 - 622 (2007/10/02)
The authors describe the synthesis of and of two analogues, the ring of which were expanded by the insertion of 1 or 2 molecules of ε-aminocaproic acid.The cyclopeptides had been tested for their activity as to the smooth musculature.The cyclo- as well as the analogue expanded by ε-aminocaproic acid exhibit a behaviour typically of the partial agonists.