1018631-63-4

Basic information

• Product Name: 4-(4-pyridin-3-ylmethyl-piperazin-1-yl)-benzoic acid
• Synonyms: 4-(4-pyridin-3-ylmethyl-piperazin-1-yl)-benzoic acid
• CAS NO: 1018631-63-4
• Molecular Weight: 297.357
• Mol File: 1018631-63-4.mol
• Article Data: 2

Chemical Properties

• CAS DataBase Reference: 4-(4-pyridin-3-ylmethyl-piperazin-1-yl)-benzoic acid(CAS DataBase Reference)
• NIST Chemistry Reference: 4-(4-pyridin-3-ylmethyl-piperazin-1-yl)-benzoic acid(1018631-63-4)
• EPA Substance Registry System: 4-(4-pyridin-3-ylmethyl-piperazin-1-yl)-benzoic acid(1018631-63-4)

Safety Data

• Hazardous Substances Data: 1018631-63-4(Hazardous Substances Data)

Upstream product

• 39244-80-9 1-(pyridin-3-ylmethyl)piperazine 
• 1194-02-1 4-fluorobenzonitrile 
• 617691-08-4 4-(4-pyridin-3-ylmethylpiperazin-1-yl)benzonitrile 

Downstream Products

• 617691-09-5 3-(4-{[4-(4-pyridin-3-ylmethylpiperazin-1-yl)benzoylamino]methyl}phenyl)acrylic acid ethyl ester 

Relevant articles and documents

Synthesis and Biological Evaluation of 3-(4-Substituted-phenyl)-N-hydroxy-2-propenamides, a New Class of Histone Deacetylase Inhibitors

Inhibitors of histone deacetylases (HDACs) have been shown to induce differentiation and/or apoptosis of human tumor cells. Novel 3-(4-substituted-phenyl)-N-hydroxy-2-propenamides have been prepared as a new class of HDAC inhibitors and evaluated for their antiproliferative activity and HDAC inhibitory activity. Incorporation of a 1,4-phenylene carboxamide linker, shown by 5, and a 4-(dimethylamino)phenyl or 4-(pyrrolidin-1-yl)phenyl group as a cap substructure generated highly potent hydroxamic acid-based HDAC inhibitors 5a and 5b.