101904-29-4Relevant articles and documents
Synthesis and evaluation of 5-substituted 2′-deoxyuridine monophosphate analogues as inhibitors of flavin-dependent thymidylate synthase in mycobacterium tuberculosis
K?gler, Martin,Vanderhoydonck, Bart,De Jonghe, Steven,Rozenski, Jef,Van Belle, Kristien,Herman, Jean,Louat, Thierry,Parchina, Anastasia,Sibley, Carol,Lescrinier, Eveline,Herdewijn, Piet
, p. 4847 - 4862 (2011/09/19)
A series of 5-substituted 2′-deoxyuridine monophosphate analogues has been synthesized and evaluated as potential inhibitors of mycobacterial ThyX, a novel flavin-dependent thymidylate synthase in Mycobacterium tuberculosis. A systematic SAR study led to the identification of compound 5a, displaying an IC50 value against mycobacterial ThyX of 0.91 μM. This derivative lacks activity against the classical mycobacterial thymidylate synthase ThyA (IC50 > 50 μM) and represents the first example of a selective mycobacterial FDTS inhibitor.
Expanding the chemistry of DNA for in vitro selection
Vaught, Jonathan D.,Bock, Chris,Carter, Jeff,Fitzwater, Tim,Otis, Matt,Schneider, Dan,Rolando, Justin,Waugh, Sheela,Wilcox, Sheri K.,Eaton, Bruce E.
scheme or table, p. 4141 - 4151 (2010/05/15)
Six new 5-posltlon modified dUTP derivatives connected by a unique amide linkage were synthesized and tested for compatibility with the enzymatic steps of In vitro selection. Six commercially available DNA polymerases were tested for their ability to effi