1019642-47-7Relevant articles and documents
On-virus construction of polyvalent glycan ligands for cell-surface receptors
Kaltgrad, Eiton,O'Reilly, Mary K.,Liao, Liang,Han, Shoufa,Paulson, James C.,Finn
, p. 4578 - 4579 (2008)
Glycans arrayed on the exterior of virus particles were used as substrates for glycosyltransferase reactions to build di- and trisaccharides from the virus surface. The resulting particles exhibited tight and specific associations with cognate receptors on beads and cells, in one example defeating in cis cell-surface interactions in a manner characteristic of polyvalent binding. Combined with the ability of viruses to provide structurally well-defined attachment points, the methodology provides a convenient and powerful way to prepare complex carbohydrate ligands for clustered receptors. Copyright