102-49-8

Basic information

• Product Name: 3,4-Dichlorobenzylamine
• Synonyms: 3,4-DICHLOROBENZYLAMINE FOR SYNTHESIS;3,4-DICHLOROBENZYLAMINE;RARECHEM AL BW 0352;3,4-dichloro-benzenemethanamin;3,4-DICHLOROBENZYLAMINE 98%;(3,4-dichlorophenyl)methanamine;((3,4-Dichlorophenyl)methyl)amine;3,4-Dichlorobenzenemethanamine
• CAS NO: 102-49-8
• Molecular Formula: C₇H₇Cl₂N
• Molecular Weight: 176.04
• EINECS: 203-035-1
• Product Categories: Isoxazoles ,Oxazoles;Anilines, Aromatic Amines and Nitro Compounds;Amines;C7;Nitrogen Compounds;Building Blocks;Chemical Synthesis;Nitrogen Compounds;Organic Building Blocks
• Mol File: 102-49-8.mol
• Article Data: 10

Chemical Properties

• Melting Point: 332-333 °C(Solv: N,N-dimethylformamide (68-12-2))
• Boiling Point: 80-82 °C (0.6 mmHg)
• Flash Point: >230 °F
• Appearance: Clear colorless to light yellow/Liquid
• Density: 1.32 g/mL at 25 °C(lit.)
• Vapor Pressure: 0.0178mmHg at 25°C
• Refractive Index: n20/D 1.578(lit.)
• Storage Temp.: Store below +30°C.
• PKA: 8.56±0.10(Predicted)
• Sensitive: Air Sensitive
• BRN: 508818
• CAS DataBase Reference: 3,4-Dichlorobenzylamine(CAS DataBase Reference)
• NIST Chemistry Reference: 3,4-Dichlorobenzylamine(102-49-8)
• EPA Substance Registry System: 3,4-Dichlorobenzylamine(102-49-8)

Safety Data

• Hazard Codes: C,Xi
• Statements: 34
• Safety Statements: 23-26-36/37/39-45
• RIDADR: UN 2735 8/PG 3
• WGK Germany: 3
• TSCA: Yes
• HazardClass: 8
• PackingGroup: III
• Hazardous Substances Data: 102-49-8(Hazardous Substances Data)

Usage

Description

3,4-Dichlorobenzylamine is a benzylamine compound, which belongs to a class of small-molecule compounds with simple structures. These compounds are widely found in the biological world and possess significant physiological and pharmacological activities. They are extensively utilized in the research and development of antibacterial drugs, with a clear colorless to light yellow liquid appearance.

Uses

Used in Pharmaceutical Industry:
3,4-Dichlorobenzylamine is used as a key component in the development of antibacterial drugs due to its potent physiological and pharmacological properties. It contributes to the creation of effective medications that target various bacterial infections.
Used in Antifungal Applications:
In the field of antifungal drugs, 3,4-Dichlorobenzylamine is used as a structural element in the synthesis of drugs like terbinafine and butenafine. These medications are designed to combat fungal infections effectively, providing relief and treatment to patients suffering from such conditions.
Used in Research and Development:
3,4-Dichlorobenzylamine is also employed in the research and development sector, where it aids in the discovery and innovation of new drugs with enhanced antibacterial and antifungal properties. Its presence in the biological world and its significant physiological and pharmacological activities make it a valuable asset in the scientific community.

InChI:InChI=1/C7H7Cl2N/c8-6-2-1-5(4-10)3-7(6)9/h1-3H,4,10H2/p+1

Upstream product

• 108011-92-3 2-(3,4-dichlorobenzyl)isoindoline-1,3-dione 
• 540-69-2 ammonium formate 
• 6287-38-3 3,4-dichlorobenzaldehyde 
• 5331-92-0 3,4-dichlorobenzaldehyde oxime 
• 102-47-6 3,4-Dichlorophenylmethyl chloride 
• 100-46-9 benzylamine 
• 6574-99-8 3,4-dichloro-benzonitrile 
• 99613-63-5 4-(azidomethyl)-1,2-dichlorobenzene 

Downstream Products

• 73728-65-1 (2-ethoxy-ethyl)-(3,4-dichloro-benzyl)-amine 
• 23749-87-3 1,3-bis-(3,4-dichloro-benzyl)-thiourea 
• 103905-73-3 N-(3,4-dichloro-benzyl)-β-alanine nitrile 
• 103905-93-7 3-chloro-propionic acid-(3,4-dichloro-benzylamide) 
• 6176-08-5 3-(3,4-dichloro-benzyl)-5-(3-piperidin-1-yl-propyl)-[1,3,5]thiadiazinane-2-thione 
• 21913-12-2 Bis-<3,4-dichlor-benzyl>-amin 
• 111413-68-4 3,4-Dichlor-benzyl-thiocarbamidsaeure-<4-hexyl-phenyl-ester> 
• 50591-77-0 (3,4-dichloro-benzyl)-(5-nitro-thiazol-2-yl)-amine 
• 26367-13-5 3-(3,4-dichloro-benzyl)-5-(2-hydroxy-ethyl)-[1,3,5]thiadiazinane-2-thione 
• 99450-28-9 ethyl N-(3,4-dichlorobenzyl)glycinate 
• 109592-31-6 3,4-Dichlor-benzyl-thiocarbamidsaeure-<4-chlor-phenyl-ester> 
• 97723-35-8 3,4-Dichlor-benzyl-thiocarbamidsaeure-<4-methoxy-phenyl-ester> 
• 736-47-0 3,4-Dichlor-benzyl-thiocarbamidsaeure-<4-fluor-phenyl-ester> 
• 95704-45-3 N,N'-Bis-<3,4-dichlor-benzyl>-sebacinsaeurediamid 

Relevant articles and documents

Ultra-small cobalt nanoparticles from molecularly-defined Co-salen complexes for catalytic synthesis of amines

We report the synthesis of in situ generated cobalt nanoparticles from molecularly defined complexes as efficient and selective catalysts for reductive amination reactions. In the presence of ammonia and hydrogen, cobalt-salen complexes such as cobalt(ii)-N,N′-bis(salicylidene)-1,2-phenylenediamine produce ultra-small (2-4 nm) cobalt-nanoparticles embedded in a carbon-nitrogen framework. The resulting materials constitute stable, reusable and magnetically separable catalysts, which enable the synthesis of linear and branched benzylic, heterocyclic and aliphatic primary amines from carbonyl compounds and ammonia. The isolated nanoparticles also represent excellent catalysts for the synthesis of primary, secondary as well as tertiary amines including biologically relevant N-methyl amines.

A benzylamine synthetic method of the compound (by machine translation)

The invention discloses a compound of formula (V) indicated by the benzylamine compound synthetic methods: shown in formula (IV) of the phenmethyl nitrine as raw materials, in the boron tribromide, solvent A and gas B under the protection of the reduction reaction, after the reaction, the solvent C quenching, after treatment [...] (V) indicated by the benzylamine compound. Compared with the existing method, the invention adopts the mild reaction conditions of boron tribromide reagent, avoid the use of a metal catalyst, the operation is simple, the reaction yield is high. (by machine translation)

Versatile Dynamic Covalent Assemblies for Probing π-Stacking and Chirality Induction from Homotopic Faces

Herein we report for the first time the use of dynamic covalent reactions (DCRs) for building a π-stacking model system and further quantifying its substituent effects (SEs), which remain a topic of debate despite the rich history of stacking. A general DCR between 10-methylacridinium ion and primary amines was discovered, in which π-stacking played a stabilizing role. Facile quantification of SEs with in situ competing π-stacking systems was next achieved in the form of amine exchange exhibiting structural diversity by simply varying components. The linear correlation with σm in Hammett plots indicates the dominance of purely electrostatic SEs, and the additivity of SEs is in line with the direct interaction model. With α-chiral amines π-stacking within the adduct enabled chirality transfer from homotopic faces. The strategy of dynamic covalent assembly should be appealing to future research of probing weak interactions and manipulating chirality.