1020106-50-6

Basic information

• Product Name: 1-(2,4-dichlorophenyl)-4-methyl-5-[((E)-pent-1-enyl)thiophen-2-yl]-1H-pyrazole-3-carboxylic acid ethyl ester
• Synonyms: 1-(2,4-dichlorophenyl)-4-methyl-5-[((E)-pent-1-enyl)thiophen-2-yl]-1H-pyrazole-3-carboxylic acid ethyl ester
• CAS NO: 1020106-50-6
• Molecular Weight: 449.401
• Mol File: 1020106-50-6.mol
• Article Data: 3

Chemical Properties

• CAS DataBase Reference: 1-(2,4-dichlorophenyl)-4-methyl-5-[((E)-pent-1-enyl)thiophen-2-yl]-1H-pyrazole-3-carboxylic acid ethyl ester(CAS DataBase Reference)
• NIST Chemistry Reference: 1-(2,4-dichlorophenyl)-4-methyl-5-[((E)-pent-1-enyl)thiophen-2-yl]-1H-pyrazole-3-carboxylic acid ethyl ester(1020106-50-6)
• EPA Substance Registry System: 1-(2,4-dichlorophenyl)-4-methyl-5-[((E)-pent-1-enyl)thiophen-2-yl]-1H-pyrazole-3-carboxylic acid ethyl ester(1020106-50-6)

Safety Data

• Hazardous Substances Data: 1020106-50-6(Hazardous Substances Data)

Upstream product

• 1013649-25-6 5-(5-bromothiophen-2-yl)-1-(2,4-dichloro-phenyl)-4-methyl-5-thiophen-2-yl-1H-pyrazole-3-carboxylic acid ethyl ester 
• 104376-24-1 (E)-1-pentenylboronic acid 

Downstream Products

• 1020106-51-7 (E)-1-(2,4-dichlorophenyl)-4-methyl-5-(5-(pent-1-enyl)thiophen-2-yl)-1H-pyrazole-3-carboxylic acid 
• 1020106-71-1 [1-(2,4-dichloro-phenyl)-4-methyl-5-(5-pent-1-enyl-thiophen-2-yl)-1H-pyrazol-3-yl]methanol 

Relevant articles and documents

Design, synthesis, and biological evaluation of novel alkenylthiophenes as potent and selective CB1 cannabinoid receptor antagonists

A novel class of (5-(pent-1-enyl)thiophen-2-yl)pyrazole antagonists was discovered, many of which exhibited potent CB1 activity and good CB1/2 selectivity, suggesting that along with a 1,3-transposition of the carbonyl of the pyrazole 3-carboxamide, bioisosteric replacement of the conventional pyrazole 5-aryl group with a thienyl ring substituted with an appropriate alkenyl moiety is viable. The Royal Society of Chemistry 2008.

THIOPHENE COMPOUNDS

This invention relates to thiophene compounds of formula (I) shown below: Each variable in formula (I) is defined in the specification. These compounds can be used to treat cannabinoid-receptor mediated disorders.