1021854-28-3 Usage
Description
N-(3-((5-chloro-1H-pyrrolo[2,3-b]pyridin-3-yl)(hydroxy)Methyl)-2,4-difluorophenyl)propane-1-sulfonaMide is a complex chemical compound characterized by a sulfonamide functional group, a fluorophenyl group, and a chloro-pyrrolopyridine moiety. It also includes a hydroxymethyl group, enhancing its hydrophilicity, and the presence of fluorine atoms suggests high lipophilicity. The sulfonamide group indicates its potential as a hydrogen bond donor and acceptor. These structural features hint at possible applications in medicinal chemistry and pharmaceutical research.
Uses
Used in Medicinal Chemistry:
N-(3-((5-chloro-1H-pyrrolo[2,3-b]pyridin-3-yl)(hydroxy)Methyl)-2,4-difluorophenyl)propane-1-sulfonaMide is used as a compound in medicinal chemistry for its unique structural properties that may contribute to the development of new drugs.
Used in Pharmaceutical Research:
In pharmaceutical research, N-(3-((5-chloro-1H-pyrrolo[2,3-b]pyridin-3-yl)(hydroxy)Methyl)-2,4-difluorophenyl)propane-1-sulfonaMide is utilized for its potential to be a key component in the synthesis of novel therapeutic agents, given its diverse functional groups and chemical reactivity.
Check Digit Verification of cas no
The CAS Registry Mumber 1021854-28-3 includes 10 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 7 digits, 1,0,2,1,8,5 and 4 respectively; the second part has 2 digits, 2 and 8 respectively.
Calculate Digit Verification of CAS Registry Number 1021854-28:
(9*1)+(8*0)+(7*2)+(6*1)+(5*8)+(4*5)+(3*4)+(2*2)+(1*8)=113
113 % 10 = 3
So 1021854-28-3 is a valid CAS Registry Number.
1021854-28-3Relevant articles and documents
Rapid, microwave-assisted organic synthesis of selective V600EBRAF inhibitors for preclinical cancer research
Buck, Jason R.,Saleh, Sam,Imam Uddin, Md.,Manning, H. Charles
, p. 4161 - 4165 (2012)
We report dramatically improved total syntheses of two highly selective V600EBRAF inhibitors, PLX4720 and PLX4032, that leverages microwave-assisted organic synthesis (MAOS). Compared with previously reported approaches, our novel MAOS method significantly reduces overall reaction time without compromising yield. In addition to providing a gram-scale route to these compounds for preclinical oncology research, we anticipate this approach could accelerate the synthesis of azaindoles in high-throughput, library-based formats.
