1021912-99-1

Basic information

• Product Name: diethyl {[(3-chloro-4-iodophenyl)amino]methylidene}propanedioate
• Synonyms: diethyl {[(3-chloro-4-iodophenyl)amino]methylidene}propanedioate
• CAS NO: 1021912-99-1
• Molecular Weight: 423.635
• Mol File: 1021912-99-1.mol
• Article Data: 8

Chemical Properties

• CAS DataBase Reference: diethyl {[(3-chloro-4-iodophenyl)amino]methylidene}propanedioate(CAS DataBase Reference)
• NIST Chemistry Reference: diethyl {[(3-chloro-4-iodophenyl)amino]methylidene}propanedioate(1021912-99-1)
• EPA Substance Registry System: diethyl {[(3-chloro-4-iodophenyl)amino]methylidene}propanedioate(1021912-99-1)

Safety Data

• Hazardous Substances Data: 1021912-99-1(Hazardous Substances Data)

Upstream product

• 135050-44-1 3-chloro-4-iodoaniline 
• 87-13-8 diethyl 2-ethoxymethylenemalonate 

Downstream Products

• 1021912-69-5 5-[7-chloro-3-(3,5-dimethylphenyl)-4-{2-[(2R)-piperidin-2-yl]ethoxy}quinolin-6-yl]pyridin-2(1H)-one 
• 1276063-77-4 7-chloro-3-(3,5-dimethylphenyl)-4-{2-[(2R)-piperidin-2-yl]ethoxy}-6-(pyridin-3-yl)quinoline 
• 1032816-26-4 C₃₆H₄₀ClN₃O₄ 

Relevant articles and documents

AMINO-QUINOLINES AS KINASE INHIBITORS

Disclosed are compounds having the formula:wherein R 1 , R 2 , R 3 and Z are as defined herein, and methods of making and using the same.

AMINO-QUINOLINES AS KINASE INHIBITORS

Disclosed are compounds having the formula: wherein R1, R2, R3 and Z are as defined herein, and methods of making and using the same.

INHIBITORS OF KRAS G12C

Compounds having activity as inhibitors of G12C mutant KRAS protein are provided. The compounds have the following structure (I): or a pharmaceutically acceptable salt, tautomer, prodrug or stereoisomer thereof, wherein R1, R2a, R3a, R3b, R4a, R4b, G1, G2, L1, L2, m1, m2, A, B, W, X, Y, Z and E are as defined herein. Methods associated with preparation and use of such compounds, pharmaceutical compositions comprising such compounds and methods to modulate the activity of G12C mutant KRAS protein for treatment of disorders, such as cancer, are also provided.