1021950-26-4

Basic information

• Product Name: Tyrosine kinase inhibitor
• Synonyms: DCL000409(XL184);N-(4-Fluorophenyl)-N'-[4-[[2-[[[2-(4-morpholinyl)ethyl]amino]carbonyl]-1H-pyrrolo[2,3-b]pyridin-4-yl]oxy]phenyl]-1,1-cyclopropanedicarboxamide;1,1-CyclopropanedicarboxaMide, N-(4-fluorophenyl)-N'-[4-[[2-[[[2-(4-Morpholinyl)ethyl]aMino]carbonyl]-1H-pyrrolo[2,3-b]pyridin-4-yl]oxy]phenyl]-
• CAS NO: 1021950-26-4
• Molecular Formula: C31H31FN6O5
• Molecular Weight: 586.6134432
• Mol File: 1021950-26-4.mol
• Article Data: 1

Chemical Properties

• Appearance: /
• Density: 1.428
• PKA: 12.22±0.40(Predicted)
• CAS DataBase Reference: Tyrosine kinase inhibitor(CAS DataBase Reference)
• NIST Chemistry Reference: Tyrosine kinase inhibitor(1021950-26-4)
• EPA Substance Registry System: Tyrosine kinase inhibitor(1021950-26-4)

Safety Data

• Hazardous Substances Data: 1021950-26-4(Hazardous Substances Data)

Usage

Description

Tyrosine kinase inhibitor is a class of molecules that specifically target and inhibit the activity of tyrosine kinase enzymes, which play a crucial role in cell signaling and regulation of various cellular processes, including cell growth, differentiation, and apoptosis. These inhibitors are designed to disrupt the abnormal cell signaling pathways that contribute to the development and progression of certain diseases, particularly cancer.

Uses

Used in Pharmaceutical Industry:
Tyrosine kinase inhibitor is used as an antiproliferative agent for the treatment of various types of cancer. It works by inhibiting the activity of tyrosine kinase enzymes, which are often overactive in cancer cells, leading to uncontrolled cell growth and proliferation. By blocking these enzymes, the tyrosine kinase inhibitor can help slow down or stop the growth of cancer cells.
Used in Combination Therapy:
Tyrosine kinase inhibitor is also used in combination with other antiproliferative agents, such as fragmenting aromatic nitrogen compounds, to enhance the overall effectiveness of cancer treatment. This combination approach can help overcome drug resistance and improve the therapeutic outcomes for patients with cancer.
Used in Research and Development:
In addition to its clinical applications, tyrosine kinase inhibitors are also used in research settings to study the role of tyrosine kinase enzymes in various cellular processes and disease pathways. These inhibitors can serve as valuable tools for understanding the molecular mechanisms underlying cancer development and progression, as well as for identifying potential targets for the development of new therapeutic strategies.

Relevant articles and documents

NOVEL COMPOUNDS

The present invention relates to compounds of formula (I): and processes for preparing them, compositions containing them and their use in treating diseases relating to inappropriate c-Met activity.