1022092-33-6 Usage
Description
4-(4,4,5,5-TetraMethyl-1,3,2-dioxaborolan-2-yl)-1H-pyrazole-1-propanenitrile is a chemical compound that features a pyrazole core with a nitrile group and a tetramethyl-1,3,2-dioxaborolan-2-yl substituent. This unique structure endows it with specific reactivity and properties that make it valuable in the field of organic synthesis.
Uses
Used in Pharmaceutical Industry:
4-(4,4,5,5-TetraMethyl-1,3,2-dioxaborolan-2-yl)-1H-pyrazole-1-propanenitrile is used as a key intermediate in the synthesis of bicyclic BET bromodomain inhibitors. Bromodomain and extra-terminal (BET) proteins play a crucial role in regulating gene expression and are implicated in various diseases, including cancer and inflammatory disorders. 4-(4,4,5,5-TetraMethyl-1,3,2-dioxaborolan-2-yl)-1H-pyrazole-1-propanenitrile serves as a building block for developing novel therapeutic agents targeting these proteins, potentially leading to treatments for a range of conditions.
Used in Organic Synthesis:
In the realm of organic synthesis, 4-(4,4,5,5-TetraMethyl-1,3,2-dioxaborolan-2-yl)-1H-pyrazole-1-propanenitrile is utilized as a versatile reactant for the preparation of various complex organic molecules. Its tetramethyl-1,3,2-dioxaborolan-2-yl group allows for selective cross-coupling reactions, which are essential for constructing molecular frameworks with precise control over connectivity and stereochemistry. This makes it a valuable tool for the synthesis of pharmaceuticals, agrochemicals, and other specialty chemicals.
Check Digit Verification of cas no
The CAS Registry Mumber 1022092-33-6 includes 10 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 7 digits, 1,0,2,2,0,9 and 2 respectively; the second part has 2 digits, 3 and 3 respectively.
Calculate Digit Verification of CAS Registry Number 1022092-33:
(9*1)+(8*0)+(7*2)+(6*2)+(5*0)+(4*9)+(3*2)+(2*3)+(1*3)=86
86 % 10 = 6
So 1022092-33-6 is a valid CAS Registry Number.
1022092-33-6Relevant articles and documents
HETEROCYCLIC COMPOUNDS AS DELTA-5 DESATURASE INHIBITORS AND METHODS OF USE
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Page/Page column 102-103, (2021/06/04)
The present disclosure provides compounds useful for the inhibition of Delta-5 Desaturase ("D5D"). The compounds have a general Formula (I): wherein the variables of Formula (I) are defined herein. This disclosure also provides pharmaceutical compositions comprising the compounds, uses of the compounds, and compositions for treatment of, for example, a metabolic or cardiovascular disorder. Further, the disclosure provides intermediates useful in the synthesis of compounds of Formula (I).
AMINOPYRAZINE COMPOUNDS AS HPK1 INHIBITOR AND THE USE THEREOF
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Page/Page column 115; 118, (2021/02/26)
Disclosed herein is an aminopyrazine compound of Formula (I), or a stereoisomer thereof, or a pharmaceutically acceptable salt thereof, and pharmaceutical compositions comprising thereof. Also disclosed is a method of treating HPK1 related disorders or diseases by using the compound disclosed herein.
HETEROARYL COMPOUNDS AND PHARMACEUTICAL APPLICATIONS THEREOF
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Paragraph 00500, (2016/01/25)
The present invention provides herein is a heteroaryl compound or a stereoisomer, a geometric isomer, a tautomer, a racemate, an N-oxide, a hydrate, a solvate, a metabolite, a pharmaceutically acceptable salt or a prodrug thereof, as well as a pharmaceutical composition containing the compound disclosed herein. The present invention also provides herein is use of the compound or the pharmaceutical composition thereof disclosed herein in the manufacture of a medicine for treating autoimmune diseases or proliferative diseases.