10226-64-9 Usage
Explanation
The molecular formula represents the number of atoms of each element present in a molecule of the compound.
Explanation
Purine is a heterocyclic compound that is commonly found in nucleic acids and various natural products.
Explanation
Theophylline is an alternative name for 1,3-dimethyl-7-(2-oxopropyl)-3,7-dihydro-1H-purine-2,6-dione.
Explanation
Theophylline belongs to the class of methylxanthine drugs, which are alkaloids that contain a methylated xanthine structure.
Explanation
Theophylline is used to treat conditions like asthma and chronic obstructive pulmonary disease (COPD) by relaxing the smooth muscles in the airways, improving breathing.
Explanation
Theophylline works by causing the smooth muscles in the airways to relax, which helps to open up the airways and improve breathing.
Explanation
Besides its bronchodilator properties, theophylline also has mild diuretic effects (increasing urine production) and acts as a stimulant to the central nervous system.
Explanation
Theophylline can be found naturally in some foods, such as tea and cocoa, in small quantities.
Explanation
Due to its stimulant effects on the central nervous system, theophylline has been used as a doping agent in sports, although it is not commonly used for this purpose today.
Derivative of purine
Heterocyclic organic compound
Classification
Methylxanthine drug
Medical use
Bronchodilator and treatment of respiratory diseases
Mechanism of action
Relaxation of smooth muscles in the airways
Additional effects
Mild diuretic and central nervous system stimulant
Presence in food
Found in small amounts in tea and cocoa
Use as a doping agent
Sometimes used in sports
Check Digit Verification of cas no
The CAS Registry Mumber 10226-64-9 includes 8 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 5 digits, 1,0,2,2 and 6 respectively; the second part has 2 digits, 6 and 4 respectively.
Calculate Digit Verification of CAS Registry Number 10226-64:
(7*1)+(6*0)+(5*2)+(4*2)+(3*6)+(2*6)+(1*4)=59
59 % 10 = 9
So 10226-64-9 is a valid CAS Registry Number.
10226-64-9Relevant articles and documents
Potentiation of cADPR-induced Ca2+-release by methylxanthine analogues
Cavallaro, Rosaria A.,Filocamo, Luigi,Galuppi, Annamaria,Galione, Antony,Brufani, Mario,Genazzani, Armando A.
, p. 2527 - 2534 (2007/10/03)
Caffeine and other methylxanthines are known to induce Ca2+-release from intracellular stores via the ryanodine receptor. In the present work, a range of caffeine analogues, in which methyl groups at the 1 and 7 positions were replaced with alkyl chains containing different functional groups (oxo, hydroxyl, propargyl, ester, and acids), were synthesized. These compounds were then screened for their ability to potentiate Ca2+-release induced by cADPR (an endogenous modulator of ryanodine receptors) in sea urchin egg homogenates. Two of the synthesized methylxanthines, 1,3-dimethyl-7-(7- hydroxyoctyl)xanthine (37) and 3-methyl-7-(7-oxooctyl)-1-propargylxanthine (66), were shown to be more potent than caffeine in potentiating cADPR- induced Ca2+-release, while 1,3-dimethyl-7-(5-ethylcarboxypentyl)xanthine (14) was shown to be more efficacious. The development of new methylxanthine analogues may lead to a better understanding of ryanodine receptor function and could possibly provide novel therapeutic agents.