1022976-32-4Relevant articles and documents
A first synthesis of a phosphatidylcholine bearing docosahexaenoic and tetracosahexaenoic acids
Baba, Naomichi,Alam, Md. Khorshed,Mori, Yoshihiro,Haider, Syed S.,Tanaka, Masatoshi,Nakajima, Shuhei,Shimizu, Sakayu
, p. 221 - 223 (2001)
The synthesis of phosphatidylcholine bearing docosahexaenoic and tetracosahexaenoic acids was presented. The method constituted two-carbon elongation of DHA ethyl ester to give an acid and synthesis of lysophosphatidylcholine starting from lipase catalyzed mono-acylation of 2-OoTBDMS-glycerol followed by the introduction of the silyl group. It was found that hydrogenolysis cannot be applied after acylation at the 1-position with unsaturated fatty acyl group because of the inevitable saturation of the olefinic bonds.
ALPHA-SUBSTITUTED OMEGA-3 LIPIDS THAT ARE ACTIVATORS OR MODULATORS OF THE PEROXISOME PROLIFERATORS-ACTIVATED RECEPTOR (PPAR).
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Page/Page column 63-64, (2008/12/05)
Omega-3 lipid compounds of the general formula (I): wherein R1 and R2 are the same or different and may be selected from a group of substitu- ents consisting of a hydrogen atom, a hydroxy group, an alkyl group, a halogen atom, an alkoxy group, an acyloxy group, an acyl group, an alkenyl group, an al- kynyl group, an aryl group, an alkylthio group, an alkoxycarbonyl group, a car- boxy group, an alkylsulfmyl group, an alkylsulfonyl group, an amino group, and an alkylamino group; - X represents a carboxylic acid or a derivative thereof, a carboxylate, a carboxylic anhydride or a carboxamide; and - Y is a C16 to C22 alkene with two or more double bonds, having E and/or Z configuration, are disclosed. Also disclosed are pharmaceutical compositions and lipid compositions comprising such compounds, and to such compounds for use as medicaments in particular for the treatment of cardiovascular and metabolic diseases.
