102318-13-8Relevant articles and documents
Structure-based optimization of arylamides as inhibitors of soluble epoxide hydrolase
Eldrup, Anne B.,Soleymanzadeh, Fariba,Taylor, Steven J.,Muegge, Ingo,Farrow, Neil A.,Joseph, David,McKellop, Keith,Man, Chuk C.,Kukulka, Alison,De Lombaert, Stéphane
experimental part, p. 5880 - 5895 (2010/03/24)
Inhibition of soluble epoxide hydrolase (sEH) is hypothesized to lead to an increase in circulating levels of epoxyeicosatrienoic acids, resulting in the potentiation of their in vivo pharmacological properties. As part of an effort to identify inhibitors