102392-17-6

Basic information

• Product Name: 4-Chloro-5-chlorosulfonyl-2-methyl-benzoic acid
• Synonyms: 4-Chloro-5-chlorosulfonyl-2-methyl-benzoic acid
• CAS NO: 102392-17-6
• Molecular Weight: 269.105
• Mol File: 102392-17-6.mol
• Article Data: 2

Chemical Properties

• CAS DataBase Reference: 4-Chloro-5-chlorosulfonyl-2-methyl-benzoic acid(CAS DataBase Reference)
• NIST Chemistry Reference: 4-Chloro-5-chlorosulfonyl-2-methyl-benzoic acid(102392-17-6)
• EPA Substance Registry System: 4-Chloro-5-chlorosulfonyl-2-methyl-benzoic acid(102392-17-6)

Safety Data

• Hazardous Substances Data: 102392-17-6(Hazardous Substances Data)

Upstream product

• 7499-07-2 4-chloro-2-methylbenzoic acid 

Downstream Products

• 757168-33-5 5-Methanesulfonyl-2-methyl-4-(4-methyl-imidazol-1-yl)-benzoic acid 
• 190368-07-1 5-Methanesulfonyl-2-methyl-4-(4-pyrimidin-2-yl-piperazin-1-yl)-benzoic acid methyl ester 
• 1027398-47-5 5-Methanesulfonyl-2-methyl-4-(4-pyrimidin-2-yl-piperazin-1-yl)-benzoic acid 

Relevant articles and documents

Small Molecule Microarray Based Discovery of PARP14 Inhibitors

Poly(ADP-ribose) polymerases (PARPs) are key enzymes in a variety of cellular processes. Most small-molecule PARP inhibitors developed to date have been against PARP1, and suffer from poor selectivity. PARP14 has recently emerged as a potential therapeutic target, but its inhibitor development has trailed behind. Herein, we describe a small molecule microarray-based strategy for high-throughput synthesis, screening of >1000 potential bidentate inhibitors of PARPs, and the successful discovery of a potent PARP14 inhibitor H10 with >20-fold selectivity over PARP1. Co-crystallization of the PARP14/H10 complex indicated H10 bound to both the nicotinamide and the adenine subsites. Further structure–activity relationship studies identified important binding elements in the adenine subsite. In tumor cells, H10 was able to chemically knockdown endogenous PARP14 activities.