10242-10-1

Basic information

• Product Name: 5-CHLOROBENZOFURAN-2-CARBOXYLIC ACID
• Synonyms: ASISCHEM D19360;ASINEX-REAG BAS 12719327;BUTTPARK 40\07-65;5-CHLOROBENZOFURAN-2-CARBOXYLIC ACID;5-Chlorobenzo[b]furan-2-carboxylic acid;5-Chlorobenzofuran-2-carboxylic acid ,97%;5-Chloro-2-benzofurancarboxylic acid;5-Chlorocoumarilic acid
• CAS NO: 10242-10-1
• Molecular Formula: C₉H₅ClO₃
• Molecular Weight: 196.59
• Mol File: 10242-10-1.mol
• Article Data: 12

Chemical Properties

• Melting Point: 275°C (subl.)
• Boiling Point: 348.8 °C at 760 mmHg
• Flash Point: 164.7 °C
• Appearance: /
• Density: 1.502
• Vapor Pressure: 1.84E-05mmHg at 25°C
• Storage Temp.: 2-8°C
• PKA: 2.94±0.30(Predicted)
• CAS DataBase Reference: 5-CHLOROBENZOFURAN-2-CARBOXYLIC ACID(CAS DataBase Reference)
• NIST Chemistry Reference: 5-CHLOROBENZOFURAN-2-CARBOXYLIC ACID(10242-10-1)
• EPA Substance Registry System: 5-CHLOROBENZOFURAN-2-CARBOXYLIC ACID(10242-10-1)

Safety Data

• Hazard Codes: Xi
• Statements: 36/37/38
• Safety Statements: 26-36/37/39
• HazardClass: IRRITANT
• Hazardous Substances Data: 10242-10-1(Hazardous Substances Data)

Usage

Chemical Properties

Light red powder

InChI:InChI=1/C9H5ClO3/c10-6-1-2-7-5(3-6)4-8(13-7)9(11)12/h1-4H,(H,11,12)/p-1

Upstream product

• 685-87-0 Diethyl 2-bromomalonate 
• 635-93-8 5-chlorosalicyclaldehyde 
• 59962-89-9 ethyl 5-chlorobenzofuran-2-carboxylate 
• 79-11-8 chloroacetic acid 
• 1927-94-2 3-chlorosalicylaldehyde 
• 17798-46-8 (4-chloro-2-formyl-phenoxy)-acetic acid ethyl ester 
• 95186-48-4 4-chloro-2-<2',2'-dibromo ethenyl>-phenol 
• 13939-06-5 molybdenum hexacarbonyl 

Downstream Products

• 34385-94-9 (+/-)-5-chloro-2,3-dihydro-1-benzofuran-2-carboxylic acid 
• 337530-26-4 5-Chloro-N-[(1S)-2-[[2-[4-(4-chlorophenyl)-1-piperazinyl]-2-oxoethyl]amino]-2-oxo-1-(pyridin-2-ylmethyl)ethyl]-1-benzofuran-2-carboxamide 
• 474070-08-1 5-chlorobenzofuran-2-formyl chloride 

Relevant articles and documents

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Tandem Synthesis of 2-Carboxybenzofurans via Sequential Cu-Catalyzed C-O Coupling and Mo(CO)6-Mediated Carbonylation Reactions

A modular tandem synthesis of 2-carboxybenzofurans from 2-gem-dibromovinylphenols has been established based on a sequence of Cu-catalyzed intramolecular C-O coupling and Mo(CO)6-mediated intermolecular carbonylation reactions. This protocol allowed one-step access to a broad variety of functionalized benzofuran-2-carboxylic acids, esters, and amides in good to excellent yields under Pd- and CO gas-free conditions.

INHIBITORS OF DRUG-RESISTANT MYCOBACTERIUM TUBERCULOSIS

The present invention provides novel indoleamide compounds for treating tuberculosis, including drug-resistant M-tuberculosis, compositions comprising the indoleamides and methods of using the indoleamides in conjunction with other biologically active agents for the treatment of tuberculosis in a subject in need thereof.

Convenient synthesis of some 3-phenyl-1-benzofuran-2-carboxylic acid derivatives as new potential inhibitors of ClC-Kb channels

Improved experimental conditions were carried out for the preparation in high yields of some 3-phenyl-1-benzofuran-2-carboxylic acids, potent inhibitors of ClC-K chloride channels. A one-pot condensation-cyclization was set up starting from different 2-hy