1025877-49-9

Basic information

• Product Name: 2-{[2-(4-methoxyphenyl)-5-methyl-2H-pyrazol-3-ylamino]methylene}malonic acid diethyl ester
• Synonyms: 2-{[2-(4-methoxyphenyl)-5-methyl-2H-pyrazol-3-ylamino]methylene}malonic acid diethyl ester
• CAS NO: 1025877-49-9
• Molecular Weight: 373.409
• Mol File: 1025877-49-9.mol
• Article Data: 4

Chemical Properties

• CAS DataBase Reference: 2-{[2-(4-methoxyphenyl)-5-methyl-2H-pyrazol-3-ylamino]methylene}malonic acid diethyl ester(CAS DataBase Reference)
• NIST Chemistry Reference: 2-{[2-(4-methoxyphenyl)-5-methyl-2H-pyrazol-3-ylamino]methylene}malonic acid diethyl ester(1025877-49-9)
• EPA Substance Registry System: 2-{[2-(4-methoxyphenyl)-5-methyl-2H-pyrazol-3-ylamino]methylene}malonic acid diethyl ester(1025877-49-9)

Safety Data

• Hazardous Substances Data: 1025877-49-9(Hazardous Substances Data)

Upstream product

• 3471-32-7 4-Methoxyphenylhydrazine 
• 19501-58-7 4-methoxyphenylhydrazine hydrochloride 
• 87-13-8 diethyl 2-ethoxymethylenemalonate 
• 91331-86-1 2-(4-methoxyphenyl)-5-methyl-2H-pyrazol-3-ylamine 

Downstream Products

• 1417333-20-0 1-(4-methoxyphenyl)-3-methyl-1H-pyrazolo[3,4-b]pyridine-4-carbonitrile 
• 1417333-24-4 1-(4-methoxyphenyl)-3-methyl-1H-pyrazolo[3,4-b]pyridine-4-carbonitrile 
• 1417333-23-3 4-bromo-1-(4-methoxyphenyl)-3-methyl-1H-pyrazolo[3,4-b]pyridine 
• 1417333-22-2 1-(4-methoxyphenyl)-3-methyl-1H-pyrazolo[3,4-b]pyridin-4-ol 
• 1417333-21-1 4-hydroxy-1-(4-methoxyphenyl)-3-methyl-1H-pyrazolo[3,4-b]pyridine-5-carboxylic acid 
• 851521-65-8 4-chloro-1-(4-methoxy-phenyl)-3-methyl-1H-pyrazolo[3,4-b]pyridine-5-carboxylic acid 
• 1026671-56-6 4-chloro-1-(4-methoxy-phenyl)-3-methyl-1H-pyrazolo[3,4-b]pyridine-5-carboxylic acid amide 
• 1027322-37-7 4-chloro-1-(4-methoxy-phenyl)-3-methyl-1H-pyrazolo[3,4-b]pyridine-5-carbonyl chloride 
• 1027842-11-0 4-chloro-1-(4-methoxyphenyl)-3-methyl-1H-pyrazolo[3,4-b]pyridine-5-carboxylic acid ethyl ester 

Relevant articles and documents

Identification, design and synthesis of novel pyrazolopyridine influenza virus nonstructural protein 1 antagonists

Nonstructural protein 1 (NS1) plays a crucial function in the replication, spread, and pathogenesis of influenza virus by inhibiting the host innate immune response. Here we report the discovery and optimization of novel pyrazolopyridine NS1 antagonists that can potently inhibit influenza A/PR/8/34 replication in MDCK cells, rescue MDCK cells from cytopathic effects of seasonal influenza A strains, reverse NS1-dependent inhibition of IFN-β gene expression, and suppress the slow growth phenotype in NS1-expressing yeast. These pyrazolopyridines will enable researchers to investigate NS1 function during infection and how antagonists can be utilized in the next generation of treatments for influenza infection.

PYRAZOLOPYRIDINES USEFUL IN THE TREATMENT OF DISORDERS OF THE CENTRAL NERVOUS SYSTEM

The present invention relates to compounds useful in therapy, to compositions comprising said compounds, and to methods of treating diseases comprising administration of said com- pounds. The compounds referred to are positive allosteric modulators (PAMs) of the nicotinic acetylcholine α7 receptor.