1025911-15-2

Basic information

• Product Name: 3-Imidazol-1-ylmethyl-1-{3-[4-(4-methoxy-benzyl)-piperazin-1-yl]-propyl}-1H-indole-6-carboxylic acid methyl ester
• CAS NO: 1025911-15-2
• Molecular Weight: 501.629
• Mol File: 1025911-15-2.mol
• Article Data: 1

Chemical Properties

• CAS DataBase Reference: 3-Imidazol-1-ylmethyl-1-{3-[4-(4-methoxy-benzyl)-piperazin-1-yl]-propyl}-1H-indole-6-carboxylic acid methyl ester(CAS DataBase Reference)
• NIST Chemistry Reference: 3-Imidazol-1-ylmethyl-1-{3-[4-(4-methoxy-benzyl)-piperazin-1-yl]-propyl}-1H-indole-6-carboxylic acid methyl ester(1025911-15-2)
• EPA Substance Registry System: 3-Imidazol-1-ylmethyl-1-{3-[4-(4-methoxy-benzyl)-piperazin-1-yl]-propyl}-1H-indole-6-carboxylic acid methyl ester(1025911-15-2)

Safety Data

• Hazardous Substances Data: 1025911-15-2(Hazardous Substances Data)

Upstream product

• 21867-69-6 1-(4-methoxybenzyl)piperazine 
• 172544-72-8 methyl 1-(3-chloropropyl)-3-(1H-imidazol-1-ylmethyl)-1H-indole-6-carboxylate 
• 50820-65-0 indole-6-carboxylic acid methyl ester 
• 96-98-0 4-methyl-3-nitrobenzoic acid 
• 172544-70-6 methyl 3-((dimethylamino)methyl)-1H-indole-6-carboxylate 
• 104447-80-5 (E)-1-(dimethylamino)-2-[4-(methoxycarbonyl)-2-nitrophenyl]ethene 
• 7356-11-8 4-methyl-3-nitro-benzoic acid methyl ester 

Relevant articles and documents

Thromboxane A2 synthetase inhibitors with histamine H1-blocking activity: Synthesis and evaluation of a new series of indole derivatives

A novel series of N-substituted 3-(1H-imidazol-1-ylmethyl)indole carboxylic acid derivatives were prepared and evaluated for thromboxane A2 (TXA2) synthetase-inhibitory and histaminergic H1-blocking activity. Among the compounds synthesized, indole-6-carboxylic acid derivatives showed higher activities than the other positional isomers of carboxylic acid. 1-[3-(4- Benzhydryl-1-piperazinyl)propyl]-3-(1H-imidazol-1-ylmethyl)-1H-indole-6- carboxylic acid (12) had the strongest thromboxane synthetase inhibitory activity (IC50 = 5 x 10-8 M) and H1-blocking activity (IC50 = 8 x 10- 9 M).