10264-09-2

Basic information

• Product Name: N-butyl-2-phenylacetamide
• Synonyms: benzeneacetamide, N-butyl-; N-Butyl-2-phenylacetamide
• CAS NO: 10264-09-2
• Molecular Formula: C₁₂H₁₇NO
• Molecular Weight: 191.2695
• Mol File: 10264-09-2.mol
• Article Data: 42

Chemical Properties

• Boiling Point: 363.4°C at 760 mmHg
• Flash Point: 217.3°C
• Density: 0.984g/cm³
• Vapor Pressure: 1.81E-05mmHg at 25°C
• Refractive Index: 1.508
• CAS DataBase Reference: N-butyl-2-phenylacetamide(CAS DataBase Reference)
• NIST Chemistry Reference: N-butyl-2-phenylacetamide(10264-09-2)
• EPA Substance Registry System: N-butyl-2-phenylacetamide(10264-09-2)

Safety Data

• Hazardous Substances Data: 10264-09-2(Hazardous Substances Data)

Upstream product

• 101-97-3 Ethyl 2-phenylethanoate 
• 109-73-9 N-butylamine 
• 103-82-2 phenylacetic acid 
• 4254-93-7 tris-butylamino-borane 
• 937-39-3 2-phenylacetylhydrazine 
• 1666-13-3 diphenyl diselenide 
• 144809-66-5 1-<(N-Butyl-N-(phenylacetyl)carbamoyl)oxy>-2(1H)-pyridinethione 
• 109-65-9 1-bromo-butane 
• 103-81-1 Benzeneacetamide 
• 88410-05-3 (Z)-β-bromo-β-fluorostyrene 
• 7732-18-5 water 
• 101-41-7 benzeneacetic acid methyl ester 
• 103-80-0 phenylacetyl chloride 
• 51463-66-2 dimethyl (2-phenylacetyl)phosphonate 

Downstream Products

• 36910-81-3 N-Butyl-N-trimethylsilyl-phenylacetamid 
• 104515-37-9 2-Phenyl-pent-4-enoic acid butylamide 
• 29175-09-5 C₁₃H₁₆ClNO₂ 
• 144809-66-5 1-<(N-Butyl-N-(phenylacetyl)carbamoyl)oxy>-2(1H)-pyridinethione 
• 104515-39-1 3-Phenyl-5-phenylselanylmethyl-tetrahydro-furan-2-ol 
• 104515-38-0 Butyl-[3-phenyl-5-phenylselanylmethyl-dihydro-furan-(2E)-ylidene]-amine 
• 23068-45-3 N-Butyl-2-phenylethylamine 
• 1207269-20-2 3-benzyl-4-n-butyl-1-(4-trifluoromethyl)phenyl-1H-1,2,4-triazole-5(4H)-one 
• 1207269-21-3 3-(1'-bromo-benzyl)-4-n-butyl-1-(4-trifluoromethyl)phenyl-1H-1,2,4-triazole-5(4H)-one 
• 1207268-95-8 ethyl 2,2-dimethyl-2-(3-methyl-4-(1-(2-(4-n-butyl-5-oxo-1-(4-trifluoromethyl-phenyl)-4,5-dihydrogen-1H-1,2,4-triazolyl))-benzylthio)-phenoxy)-acetate 
• 1207268-96-9 ethyl 2-(2,5-dimethyl-4-(1-(3-(4-n-butyl-5-oxo-1-(4-trifluoromethyl-phenyl)-4,5-dihydrogen-1H-1,2,4-triazolyl))-benzylthio)-phenoxy)-acetate 
• 1207269-19-9 N-n-butyl-2-phenyl-N-(4-trifluoromethyl)phenylacetamide hydrazone 
• 5070-32-6 N-n-butyl-2-oxo-2-phenylacetamide 
• 60-12-8 2-phenylethanol 

Relevant articles and documents

Efficient procedure for the preparation of amides using polymer-bound reagents

An effective method for the conversion of acids into amides is presented. The two-step procedure includes the preparation of acid chloride intermediates using Pol-Ph3P and subsequent treatment of these intermediates with amines and polymer-bound base. The amides were accessible in high yields and purities without further purification.

MCF-supported boronic acids as efficient catalysts for direct amide condensation of carboxylic acids and amines

For efficient direct amide condensations, a new class of catalysts are developed by immobilizing boronic acids on mesocellular siliceous foam. Associated with their large pores, the microenvironments surrounding the immobilized active species greatly influence the catalytic activity. The fluoroalkyl moieties on the silica surface significantly enhance the catalytic performance along with easy recovery and reuse. This approach proposes a potential way to optimize various types of silica-supported catalysts. the Partner Organisations 2014.

Direct Regioselective Synthesis of Tetrazolium Salts by Activation of Secondary Amides under Mild Conditions

Tetrazolium salts are biologically active molecules that have found broad applications in biochemical assays. A regioselective synthesis of tetrazolium salts is described through a formal (3 + 2) cycloaddition. The possibility of employing simple amides and azides as starting material and the mild conditions allow a broad functional group tolerance.

[Co(MeTAA)] Metalloradical Catalytic Route to Ketenes via Carbonylation of Carbene Radicals

An efficient synthetic strategy towards beta-lactams, amides, and esters involving “in situ” generation of ketenes and subsequent trapping with nucleophiles is presented. Carbonylation of carbene radical intermediates using the cheap and highly active cobalt(II) tetramethyltetraaza[14]annulene catalyst [Co(MeTAA)] provides a convenient one-pot synthetic protocol towards substituted ketenes. N-tosylhydrazones are used as carbene precursors, thereby bridging the gap between aldehydes and ketenes. Activation of these carbene precursors by the metalloradical cobalt(II) catalyst affords CoIII-carbene radicals, which subsequently react with carbon monoxide to form ketenes. In the presence of a nucleophile (imine, alcohol, or amine) in the reaction medium the ketene is immediately trapped, resulting in the desired products in a one-pot synthetic protocol. The β-lactams formed upon reaction with imines are produced in a highly trans-selective manner.

Carboxyesterase polypeptides for amide coupling

The present invention provides engineered carboxyesterase enzymes having improved properties as compared to a naturally occurring wild-type carboxyesterase enzymes, as well as polynucleotides encoding the engineered carboxyesterase enzymes, host cells capable of expressing the engineered carboxyesterase enzymes, and methods of using the engineered carboxyesterase enzymes in amidation reactions.

Palladium-catalyzed carbonylation of benzylic ammonium salts to amides and esters: Via C-N bond activation

An efficient palladium-catalyzed carbonylation reaction of readily available quaternary ammonium salts with CO is reported for the first time to afford arylacetamides and arylacetic acid esters via benzylic C-N bond cleavage. This protocol features mild reaction conditions under atmospheric pressure of CO, a redox-neutral process without an additional oxidant, and a broad substrate scope for various kinds of amines, alcohols and phenols.