1027422-59-8

Basic information

• Product Name: [4-(5-methoxy-2-nitro-phenylcarbamoyl)-benzyl]-carbamic acid pyridin-3-ylmethyl ester
• CAS NO: 1027422-59-8
• Molecular Weight: 436.424
• Mol File: 1027422-59-8.mol
• Article Data: 1

Chemical Properties

• CAS DataBase Reference: [4-(5-methoxy-2-nitro-phenylcarbamoyl)-benzyl]-carbamic acid pyridin-3-ylmethyl ester(CAS DataBase Reference)
• NIST Chemistry Reference: [4-(5-methoxy-2-nitro-phenylcarbamoyl)-benzyl]-carbamic acid pyridin-3-ylmethyl ester(1027422-59-8)
• EPA Substance Registry System: [4-(5-methoxy-2-nitro-phenylcarbamoyl)-benzyl]-carbamic acid pyridin-3-ylmethyl ester(1027422-59-8)

Safety Data

• Hazardous Substances Data: 1027422-59-8(Hazardous Substances Data)

Upstream product

• 16133-49-6 5-methoxy-2-nitroaniline 
• 241809-79-0 4-benzoic acid 
• 212632-27-4 pyridin-3-ylmethyl 1H-imidazole-1-carboxylate 
• 100-55-0 3-hydroxymethylpyridin 

Relevant articles and documents

Synthesis and histone deacetylase inhibitory activity of new benzamide derivatives

Newly synthesized benzamide derivatives were evaluated for their inhibitory activity against histone deacetylase. The structure of these derivatives was unrelated to the known inhibitors, and IC50 values of the active compounds were in the range of 2-50 μM. Structure-activity relationship on the benzanilide moiety showed that the 2'-substituent, an amino or hydroxy group, was indispensable for inhibitory activity. Although the electronic influence of the substituent in the anilide moiety showed only a small effect on inhibitory activity, the steric factor in the anilide moiety, especially at positions 3'and 4', played an important role in interaction with the enzyme. Among these benzamide derivatives, MS-275 (1), which showed significant antitumor activity in vivo, has been selected for further investigation.