1028563-65-6

Basic information

• Product Name: (2R,3S)-2-(2,4-difluorophenyl)-3-(5-fluoropyrimidin-4-yl)-1-(4H-1,2,4-triazol-4-yl)butan-2-ol
• Synonyms: (2R,3S)-2-(2,4-difluorophenyl)-3-(5-fluoropyrimidin-4-yl)-1-(4H-1,2,4-triazol-4-yl)butan-2-ol
• CAS NO: 1028563-65-6
• Molecular Weight: 349.315
• Mol File: 1028563-65-6.mol
• Article Data: 1

Chemical Properties

• CAS DataBase Reference: (2R,3S)-2-(2,4-difluorophenyl)-3-(5-fluoropyrimidin-4-yl)-1-(4H-1,2,4-triazol-4-yl)butan-2-ol(CAS DataBase Reference)
• NIST Chemistry Reference: (2R,3S)-2-(2,4-difluorophenyl)-3-(5-fluoropyrimidin-4-yl)-1-(4H-1,2,4-triazol-4-yl)butan-2-ol(1028563-65-6)
• EPA Substance Registry System: (2R,3S)-2-(2,4-difluorophenyl)-3-(5-fluoropyrimidin-4-yl)-1-(4H-1,2,4-triazol-4-yl)butan-2-ol(1028563-65-6)

Safety Data

• Hazardous Substances Data: 1028563-65-6(Hazardous Substances Data)

Upstream product

• 288-88-0 1,2,4-Triazole 
• 1474024-68-4 4-((S)-1-((R)-2-(2,4-difluorophenyl)oxirane-2-yl)ethyl)-5-fluoropyrimidine 

Relevant articles and documents

An enantioselective synthesis of voriconazole

A new seven-step sequence to access voriconazole, a clinically used antifungal agent, was developed. The initial catalytic asymmetric cyanosilylation is the key to constructing the consecutive tetra- and trisubstituted stereogenic centers. The fluoropyrimidine unit frequently triggered unexpected side reactions, but careful amendment of the reaction sequence allowed for the concise enantioselective synthesis.