103028-63-3Relevant articles and documents
Synthesis of N-substituted benzo[c][1,7]- and benzo[c][1,8] phenanthrolin-(5H)-6-ones through a Pd-mediated Suzuki-Miyaura heteroaryl-aryl coupling reaction
Genès, Constance,Michel, Sylvie,Tillequin, Fran?ois,Porée, Fran?ois-Hugues
experimental part, p. 10009 - 10015 (2010/02/27)
In the course of the search for non-camptothecin topoisomerase I inhibitors we have undertaken the synthesis of N-substituted benzo[c][1,7]- and benzo[c][1,8]phenanthrolinone derivatives. An intermolecular Suzuki-Miyaura heteroaryl-aryl coupling reaction was planned as the key step. Then a nitro reduction followed by a concomitant lactamization achieved the construction of the tetracycle structures. This methodology permitted a rapid and efficient elaboration of biologically potent compounds.
Aromatic Ring Cleavage in 6-Methoxyquinolines and 2-Methoxynaphthalene with Fuming Nitric Acid
Balczewski, Piotr,Morris, Gareth A.,Joule, John A.
, p. 2514 - 2523 (2007/10/02)
Two 6-methoxyquinolines and 2-methoxynaphthalene, on prolonged treatment with fuming nitric acid, give major products resulting from benzene ring cleavage but retaining all carbons of the cleaved ring.Methoxyisoquinolines were not cleaved under the same conditions.
