10309-38-3Relevant articles and documents
Anti-proliferative evaluation of monoterpene derivatives against leukemia
Gautam, Lekh Nath,Ling, Taotao,Lang, Walter,Rivas, Fatima
supporting information, p. 75 - 80 (2016/03/01)
The cure rate of pediatric acute lymphoblastic leukemia (ALL) has significantly improved in the past thirty years, however not all patient cohorts respond well to current chemotherapy regimens. Among the high risk patient cohort is infants with MLL-rearranged (MLL-r) B-ALL, which remains dismal with an overall survival rate 35%. Our program is interested in identifying new molecular scaffolds to better understand the underlying mechanisms and ultimately provide new targeted treatments. Based on a phenotypic screen, phenolic natural products were identified as promising scaffolds for further chemical evaluation. Herein we disclose the effects of a potent anti-proliferative compound 31 against human ALL leukemia cellular models.
Novel bisstyryl derivatives of bakuchiol: Targeting oral cavity pathogens
Mallepally V. Reddy,Niranjan Thota,Payare L. Sangwan,Pankaj Malhotra,Furqan Ali,Inshad A. Khan,Swapandeep S. Chimni,Koul, Surrinder
experimental part, p. 3125 - 3134 (2010/09/03)
Novel bisstyryl derivatives of bakuchiol using Heck coupling reaction as the key step were synthesized and screened against a panel of six oral cavity pathogens for their antimicrobial activity. Four compounds (9-12) showed two to fourfold and four to eig
