103205-34-1Relevant articles and documents
Novel synthesis method of bromfenac sodium
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Paragraph 0073-0080; 0112-0119; 0151-0158, (2021/11/27)
The novel synthesis method is characterized by comprising the following steps: taking o-aminophenylacetic acid as a starting raw material, and performing acylation reaction to obtain the intermediate I. The intermediate I is subjected to a sulfonation reaction to obtain an intermediate II. The intermediate II is reacted with p-bromobenzoyl chloride to give an intermediate III. The intermediate III is hydrolyzed to give bromfenac. The final finished product bromfenac sodium is obtained by reacting bromfenac and sodium hydroxide. The method has the beneficial effects that an indole ring-containing impurity generated due to a synthetic method in the prior art is avoided. The problem of exceeding standard of final finished product pH caused by using phosphoric acid or glacial acetic acid to produce acid salt in the prior art is avoided.
