10325-70-9 Usage
Description
1-(5-Pyrimidinyl)ethanone, also known as 5-Acetylpyrimidine, is a substituted pyrimidine compound with a ketone group. It is characterized by its molecular structure that features a pyrimidine ring with an acetyl group attached to the 5th position. This unique structure endows it with specific chemical and biological properties, making it a versatile molecule for various applications.
Uses
Used in Pharmaceutical Industry:
1-(5-Pyrimidinyl)ethanone is used as a key intermediate in the synthesis of various pharmaceutical compounds. Its unique structure allows it to be a building block for the development of new drugs, particularly those targeting protease enzymes. It plays a crucial role in the study for the prediction of relative potency of ketone protease inhibitors using molecular orbital theory, which aids in the design and optimization of more effective therapeutic agents.
Used in Chemical Research:
In the field of chemical research, 1-(5-Pyrimidinyl)ethanone serves as a valuable compound for understanding the properties and reactivity of substituted pyrimidines. Its unique structure makes it an interesting subject for exploring various chemical reactions and transformations, contributing to the advancement of synthetic chemistry and the development of novel chemical methodologies.
Used in Drug Design and Development:
1-(5-Pyrimidinyl)ethanone is used as a structural component in the design and development of new drugs, particularly those targeting protease enzymes. Its incorporation into drug candidates can potentially enhance their potency and selectivity, leading to more effective treatments for various diseases. The study of its molecular orbital theory helps in predicting the relative potency of these inhibitors, which is essential for optimizing their therapeutic potential.
Check Digit Verification of cas no
The CAS Registry Mumber 10325-70-9 includes 8 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 5 digits, 1,0,3,2 and 5 respectively; the second part has 2 digits, 7 and 0 respectively.
Calculate Digit Verification of CAS Registry Number 10325-70:
(7*1)+(6*0)+(5*3)+(4*2)+(3*5)+(2*7)+(1*0)=59
59 % 10 = 9
So 10325-70-9 is a valid CAS Registry Number.
InChI:InChI=1/C6H6N2O/c1-5(9)6-2-7-4-8-3-6/h2-4H,1H3
10325-70-9Relevant articles and documents
A 2-amino-thiazole compounds (by machine translation)
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Paragraph 0178-0180, (2016/10/08)
The present invention relates to the technical field of pharmaceutical chemistry, particularly relates to a 2-amino thiazole compound or its pharmaceutically acceptable salts, its preparation method, and pharmaceutical compositions containing such compounds and its application in the preparation of antineoplastic. (by machine translation)
Synthesis and muscarinic activity of 1,2,3,4-tetrahydropyrimidine derivatives
Jung, Myung Hee,Park, Jewn-Giew,Yang, Kong Jae,Lee, Mi-Jeoung
, p. 79 - 85 (2007/10/03)
3-Methyl-1,2,3,4-tetrahydropyrimidine-5-carbaldehyde O-substituted oximes 4 and 1-(3-methyl-1,2,3,4-tetrahydropyrimidin-5-yl)ethanone O-substituted oximes 9 have been prepared as bioisosteric congeners of arecoline which is a muscarinic agonist for treatment of Alzheimer's disease. Starting from pyrimidine-5-carbaldehyde 1, formation of the 3-methylpyrimidinium salt and subsequent reduction afforded 1,2,3,4-tetrahydropyrimidine derivatives which were converted into oxalate salts in the interest of purity and stability. Binding affinities of prepared compounds for the cloned human muscarinic M1 receptor (h-M1) were determined by radioligand binding assay using [3H]-N-methylscopolamine (NMS).
PYRIMIDINES. 73. SYNTHESIS OF ACETYLPYRIMIDINES
Naumenko, I. I.,Mikhaleva, M. A.,Mamaev, V. P.
, p. 710 - 714 (2007/10/02)
It is shown that the use of benzene as the solvent in the preparation of 2- and 4-acetylpyrimidines from cyanopyrimidines via the Grignard reaction makes this reaction a practical method for the preparation of pyrimidinyl ketones.Preparatively convenient methods for the preparation of 4-acetylpyrimidine from 4-ethylpyrimidine through the α-oximino derivative and 5-acetylpyrimidine from 4,6-dichloro derivatives of pyrimidine are proposed.