1034257-10-7Relevant articles and documents
Fragment-based discovery of hepatitis C virus NS5b RNA polymerase inhibitors
Antonysamy, Stephen S.,Aubol, Brandon,Blaney, Jeff,Browner, Michelle F.,Giannetti, Anthony M.,Harris, Seth F.,Hebert, Normand,Hendle, Joerg,Hopkins, Stephanie,Jefferson, Elizabeth,Kissinger, Charles,Leveque, Vincent,Marciano, David,McGee, Ethel,Najera, Isabel,Nolan, Brian,Tomimoto, Masaki,Torres, Eduardo,Wright, Tobi
, p. 2990 - 2995 (2008/12/23)
Non-nucleoside inhibitors of HCV NS5b RNA polymerase were discovered by a fragment-based lead discovery approach, beginning with crystallographic fragment screening. The NS5b binding affinity and biochemical activity of fragment hits and inhibitors was de
