10344-69-1 Usage
Description
DIETHYL MALONIMIDATE DIHYDROCHLORIDE is an organic compound that serves as a key reactant in the synthesis of various chiral catalysts and complexes. It is known for its ability to form stable donor-acceptor interactions, which makes it a valuable component in the development of enantioselective catalysts.
Uses
Used in Catalyst Preparation:
DIETHYL MALONIMIDATE DIHYDROCHLORIDE is used as a reactant for the preparation of rhenium cyanobis(oxazoline) oxo complexes, which act as enantioselective reduction catalysts. These catalysts are crucial in the field of asymmetric synthesis, enabling the selective formation of specific enantiomers in chemical reactions.
Used in Asymmetric Synthesis:
In the field of asymmetric synthesis, DIETHYL MALONIMIDATE DIHYDROCHLORIDE is used as a reactant for the synthesis of chiral bis(oxazoline)-copper complexes. These complexes are immobilized by donor-acceptor interactions on insoluble organic supports, making them reusable catalysts for asymmetric Diels-Alder cycloaddition reactions. This application is significant in the production of enantiomerically pure compounds, which are essential in pharmaceuticals and agrochemicals.
Used in Enantioselective Transfer Hydrogenation:
DIETHYL MALONIMIDATE DIHYDROCHLORIDE is also used in the preparation of nonracemic bis(oxazoline)ruthenium p-cymene complexes and their silica-supported analogs. These complexes serve as catalysts for the enantioselective transfer hydrogenation of ketones to secondary alcohols. This process is vital in the synthesis of optically active alcohols, which are widely used in the pharmaceutical and chemical industries.
Overall, DIETHYL MALONIMIDATE DIHYDROCHLORIDE plays a crucial role in the development of enantioselective catalysts and complexes, which are essential in various chemical reactions and industries. Its ability to form stable donor-acceptor interactions makes it a valuable component in the synthesis of chiral catalysts, contributing to the advancement of asymmetric synthesis and enantioselective processes.
Check Digit Verification of cas no
The CAS Registry Mumber 10344-69-1 includes 8 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 5 digits, 1,0,3,4 and 4 respectively; the second part has 2 digits, 6 and 9 respectively.
Calculate Digit Verification of CAS Registry Number 10344-69:
(7*1)+(6*0)+(5*3)+(4*4)+(3*4)+(2*6)+(1*9)=71
71 % 10 = 1
So 10344-69-1 is a valid CAS Registry Number.
InChI:InChI=1/C7H13NO3/c1-3-10-6(8)5-7(9)11-4-2/h8H,3-5H2,1-2H3
10344-69-1Relevant articles and documents
CuII/TEMPO-Catalyzed Enantioselective C(sp3)–H Alkynylation of Tertiary Cyclic Amines through Shono-Type Oxidation
Chen, Zhi-Hao,Gao, Pei-Sen,Mei, Tian-Sheng,Sun, Bing,Wang, Zhen-Hua,Weng, Xin-Jun,You, Shu-Li,Zheng, Chao
, p. 15254 - 15259 (2020)
A novel strategy for asymmetric Shono-type oxidative cross-coupling has been developed by merging copper catalysis and electrochemistry, affording C1-alkynylated tetrahydroisoquinolines with good to excellent enantioselectivity. The use of TEMPO as a co-catalytic redox mediator is crucial not only for oxidizing a tetrahydroisoquinoline to an iminium ion species but also for decreasing the oxidation potential of the reaction. A novel bisoxazoline ligand is also reported.
Synthesis of C2-symmetric bisamidines: A new type of chiral metal-free lewis acid analogue interacting with carbonyl groups
Akalay, Deniz,Duerner, Gerd,Bats, Jan W.,Bolte, Michael,Goebel, Michael W.
, p. 5618 - 5624 (2007)
(Chemical Equation Presented) The chiral bisamidine 5 has been prepared in just two steps from malonodinitrile. In the monocationic form this compound adopts a planar conformation with an almost convergent orientation of two N-H groups. Ketones, aldehydes
PROCESS FOR SYNTHESIS OF PICOLINAMIDES
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Paragraph 0248, (2021/04/23)
The present technology relates to processes, mixtures and intermediates useful for making picolinamide fungicides. The picolinamide compounds are prepared by processes that include coupling together a 4-methoxy-3-acyloxypicolinic acid with key 2-amino-L-alaninate esters derived from substituted 2-phenylethanols.
Enantioselective Synthesis of N-Benzylic Heterocycles: A Nickel and Photoredox Dual Catalysis Approach
Pezzetta, Cristofer,Bonifazi, Davide,Davidson, Robert W. M.
supporting information, p. 8957 - 8961 (2019/11/11)
Reported herein is a dual nickel- and photoredox-catalyzed modular approach for the preparation of enantioenriched N-benzylic heterocycles. α-Heterocyclic carboxylic acids, easily obtainable from common commercial material, are reported as suitable substrates for a decarboxylative strategy in conjunction with a chiral pyridine-oxazoline (PyOx) ligand, providing quick access to enantioenriched drug-like products. The presence of a directing group on the heterocyclic moiety is shown to be beneficial, affording improved stereoselectivity in a number of cases.
