103457-26-7

Basic information

• Product Name: (E)-2-Cyano-3-(2-fluoro-phenyl)-acrylic acid ethyl ester
• Synonyms: (E)-2-Cyano-3-(2-fluoro-phenyl)-acrylic acid ethyl ester
• CAS NO: 103457-26-7
• Molecular Weight: 219.215
• Mol File: 103457-26-7.mol
• Article Data: 4

Chemical Properties

• CAS DataBase Reference: (E)-2-Cyano-3-(2-fluoro-phenyl)-acrylic acid ethyl ester(CAS DataBase Reference)
• NIST Chemistry Reference: (E)-2-Cyano-3-(2-fluoro-phenyl)-acrylic acid ethyl ester(103457-26-7)
• EPA Substance Registry System: (E)-2-Cyano-3-(2-fluoro-phenyl)-acrylic acid ethyl ester(103457-26-7)

Safety Data

• Hazardous Substances Data: 103457-26-7(Hazardous Substances Data)

Upstream product

• 446-52-6 2-Fluorobenzaldehyde 
• 105-56-6 ethyl 2-cyanoacetate 

Downstream Products

• 129115-58-8 C₁₇H₁₂FN₃O₂ 
• 446-52-6 2-Fluorobenzaldehyde 
• 84186-27-6 2-amino-3-ethoxycarbonyl-4-(2-fluorophenyl)-4H-naphtho<2,1-b>pyran 
• 111861-31-5 2-Amino-4-(2-fluoro-phenyl)-7-hydroxy-4H-chromene-3-carboxylic acid ethyl ester 
• 773084-46-1 2-cyano-3-(2-fluoro-phenyl)-propionic acid ethyl ester 
• 1372800-95-7 (1S,2R,3R)-triethyl 2-cyano-2'-fluoro-1,2,3,6-tetrahydro-[1,1'-biphenyl]-2,3,4-tricarboxylate 
• 1239019-89-6 (1R,2R)-diethyl 1-cyano-2-(2-fluorophenyl)cyclopent-3-ene-1,3-dicarboxylate 

Relevant articles and documents

Johnson-Corey-Chaykovsky fluorocyclopropanation of double activated alkenes: Scope and limitations

Johnson-Corey-Chaykovsky fluorocyclopropanation of double activated alkenes utilizing S-monofluoromethyl-S-phenyl-2,3,4,5-tetramethylphenylsulfonium tetrafluoroborate is an efficient approach to obtain a range of monofluorocyclopropane derivatives. So far, fluoromethylsulfonium salts have displayed the broadest scope for direct fluoromethylene transfer. In contrast to more commonly used fluorohalomethanes or freon derivatives, diarylfluoromethylsulfonium salts are bench stable, easy-to use reagents useful for the direct transfer of a fluoromethylene group to alkenes giving access to the challenging products-fluorocyclopropane derivatives. Interplay between the reactivity of the starting materials and stability of the fluorocyclopropanes formed determines the outcome of the process.

NITROGENATED HETEROCYCLIC COMPOUND AND PHARMACEUTICAL COMPOSITION COMPRISING THE SAME

The present invention relates to novel compounds having a xanthine oxidase inhibitory effect and an uricosuric effect and pharmaceutical compositions comprising the same as an active ingredient. That is, the present invention relates nitrogen-containing heterocyclic compounds represented by the following general formula (I): wherein Y1 represents N or C(R4) ; Y2 represents N or C(R5) ; R4 and R5 independently represent an alkyl group, a hydrogen atom etc. ; one of R1 and R2 represents an optionally substituted aryl group, an alkoxygroup or an optionally substituted heterocyclic group; the other of R1 and R2 represents a haloalkyl group, a cyanogroup, ahalogenatometc.; and R3 represents a 5-tetrazolyl group or a carboxy group, and pharmaceutically acceptable salts thereof, and pharmaceutical compositions comprising the same as an active ingredient.